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Comparative effectiveness of lymphotoxin anticarcinogenic and tumor cell growth-inhibitory activities.

Abstract：

:Prevention of ultraviolet radiation- or chemical carcinogen-induced morphologic transformation and inhibition of tumor-producing transformed cell growth by lymphotoxin and by normal spleen leukocytes were quantitatively compared to define the antineoplastic activity spectra of these natural immune mediators. When Syrian golden hamster embryo cells seeded for colony formation in culture dishes were treated simultaneously with carcinogen and lymphotoxin, the number of morphologically transformed cell colonies was irreversibly reduced by 50% in the presence of 6 units of lymphotoxin/ml. Lymphotoxin inhibition of tumor cell growth, however, was reversible and 50% reduction in tumor cell growth in three transformed lines required 124, 330, and 477 units/ml. Thus, the anticarcinogenic activity of lymphotoxin can be 20-fold or more greater than its tumor growth-inhibitory activity. Similarly spleen leukocytes also were more effective as an anticarcinogen than as an inhibitor of tumor cell growth, consistent with previous observations that naturally occurring spleen leukocyte antineoplastic activity may result from lymphotoxin secretion.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Evans CH,Heinbaugh JA,DiPaolo JA

doi

10.1016/0008-8749(83)90372-6

subject

Has Abstract

pub_date

1983-03-01 00:00:00

pages

295-303

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(83)90372-6

journal_volume

76

pub_type

杂志文章

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