Abstract：
:Histidine-proline-rich glycoprotein (HPRG) is a plasma protein which binds to a specific receptor on T-lymphocytes and represses T-cell activation and proliferation. In the presence of Concanavalin A (Con A), HPRG causes human T-lymphoblastic MOLT-3 cells and a fraction of normal human peripheral blood lymphocytes to attach to the culture dish and significantly change morphology by either extending processes or becoming elongated at the poles, respectively. HPRG and Con A are just as effective at inducing MOLT-3 attachment in a soluble or an immobilized form. MOLT-3 cell attachment is specific for HPRG, dose-dependent, and reversible in 72 hr. Only certain T-cell mitogenic lectins, Con A and phytohemagglutinin, are effective at stimulating adherence. Mannose, glucose, fucose, and N-acetylglucosamine inhibit HPRG-induced MOLT-3 cell attachment to different degrees, with methyl alpha-D-mannopyranoside being the most potent inhibitor. We propose that in vivo HPRG together with a naturally expressed lectin induces T-lymphocyte adhesion to initiate cell migration to sites of inflammation.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Lamb-Wharton RJ,Morgan WTdoi
10.1006/cimm.1993.1311subject
Has Abstractpub_date
1993-12-01 00:00:00pages
544-55issue
2eissn
0008-8749issn
1090-2163pii
S0008-8749(83)71311-0journal_volume
152pub_type
杂志文章abstract：:Dendritic cells (DCs) link the sensing of the environment by the innate immune system to the initiation of adaptive immune responses. Accordingly, DCs are considered to be a major target in the development of immunomodulating compounds. In this study, the effect of niclosamide, a Food and Drug Administration-approved ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2013.12.006
更新日期：2014-03-01 00:00:00
abstract：:Peripheral blood lymphocytes (PBL) from patients with herpes simplex virus (HSV)-1 recurrences in the cornea only (Group I) exhibited reduced lysis of HSV-1-infected targets compared to PBL from patients with oral-facial and corneal HSV recurrences (Group II). The cytotoxic lymphocytes appeared to belong to a subpopul...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90305-8
更新日期：1984-02-01 00:00:00
abstract：:MHC class II-restricted antigen presentation requires trafficking of newly synthesized class II-invariant chain complexes from the trans-Golgi network to endosomal, peptide-loading compartments. This transport is mediated by dileucine-like motifs within the cytosolic tail of the invariant chain. Although these signals...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2001.1817
更新日期：2001-06-15 00:00:00
abstract：:IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD)...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.04.008
更新日期：2010-01-01 00:00:00
abstract：:The pathogenic antibody response to acetylcholine receptor (AChR) in experimental autoimmune myasthenia gravis (EAMG) is T cell dependent. Therefore, it should be possible to design specific immunotherapeutic approaches to treat EAMG (and human MG) by interfering with AChR-specific helper T cells. Productive T cell ac...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.0012
更新日期：1995-11-01 00:00:00
abstract：:Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2000.1747
更新日期：2001-02-01 00:00:00
abstract：:Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2018.11.002
更新日期：2019-06-01 00:00:00
abstract：:Staphylococcal enterotoxin B (SEB) is a potent polyclonal activator of both human and murine T cells. We previously reported data which show that SEB-induced T cells suppress antibody secretion by various mouse plasmacytoma cell lines. This suppression of antibody secretion was found to be both idiotype and isotype no...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90227-i
更新日期：1990-09-01 00:00:00
abstract：:Pentraxin 3 (PTX3) is a prototype protein of long pentraxin. PTX3 is produced by various cells, such as monocytes/macrophages (Mphis) in response to lipopolysaccharide (LPS) and proinflammatory signals. We performed immunoblotting, immunohistochemical staining, reverse transcriptase-polymerase chain reaction (RT-PCR),...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2007.09.003
更新日期：2007-08-01 00:00:00
abstract：:An understanding of the interactions between immune cells and trophoblast cells, as well as choriocarcinoma cells, are of extreme importance in reproductive immunology and cancer immunology. In this study, we found that the human HLA-G-positive choriocarcinoma cell line JEG-3 upregulates CD4+CD25hiCD127lo T cells, inc...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.11.008
更新日期：2018-02-01 00:00:00
abstract：:A variety of arachidonic acid metabolites possess the ability to modulate immune cell function. Various inhibitors of arachidonic acid metabolism were compared with regard to their effects on T-suppressor (Ts) cell function. Using staphylococcal enterotoxin B (SEB) to activate Lyt-2+ Ts cells, it was shown that indome...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90211-3
更新日期：1983-10-01 00:00:00
abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90012-9
更新日期：1989-06-01 00:00:00
abstract：:The impact of BCR:CD21 co-engagement on B cell expression of molecules critical for T cell activation was investigated with receptor-specific mAbs conjugated to high MW dextran as stimulatory ligands. In the absence of IL-4, BCR:CD21 co-ligation augmented BCR-triggered CD86 only under conditions of very low BCR ligand...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(02)00512-9
更新日期：2002-03-01 00:00:00
abstract：:Peripheral blood leukocytes (PBL), nonadherent lymphocytes, and adherent monocytes separated from freshly isolated blood of 15 dogs were analyzed for their ability to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) in combination with murine anti-tumor monoclonal antibodies (MAbs). Canine monocytes isolat...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90194-3
更新日期：1988-09-01 00:00:00
abstract：:Cluster of differentiation ([CD]) 19 antigens are B-cell-specific molecules expressed on virtually all human cells of the B-lymphocyte lineage except plasma cells. We produced a new anti-CD19 monoclonal antibody (McAb), CLB-CD19, that was used to study the role of CD19 molecules in B-cell activation. Anti-CD19 McAb in...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90385-7
更新日期：1989-02-01 00:00:00
abstract：:Peripheral blood large granular lymphocytes (LGL) expressing Leu 11 (CD16) antigen with potent natural killer cytotoxicity inhibited soluble antigen-induced T-cell production of interleukin 2 (IL-2). Depletion of Leu 11-reactive cells from T-cells doubled IL-2 activity (P less than 0.05). Leu 11-enriched cells did not...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90389-4
更新日期：1989-02-01 00:00:00
abstract：:During ultrastructural studies of the early kinetics of anaphylactic degranulation and early and late recovery intervals from these release reactions induced in isolated, partially purified, cultured human lung mast cells stimulated to release histamine and granules by exposure to anti-IgE, we noted the ability of mas...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90068-2
更新日期：1987-03-01 00:00:00
abstract：:Macrophages can be divided into two groups as M1 and M2 phenotype. Our results and other groups revealed that IFN-γ can up-regulate the IDO expression and differentiate THP-1 cells to M1 phenotype. Therefore we hypothesized that IDO may play potential roles in macrophage differentiation. Interesting, our results indic...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2014.02.005
更新日期：2014-05-01 00:00:00
abstract：:Monocytes and macrophages link the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. However, if they regulate monocyte/macrophage physiology is still unkn...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.06.003
更新日期：2011-01-01 00:00:00
abstract：:To characterize the binding properties of the Fc receptors on human macrophages, the binding of radiolabeled human IgG1 to peritoneal macrophages was assessed. Cells were obtained at the time of diagnostic laparoscopy from women undergoing evaluation of infertility. Macrophages bound on the average more IgG1 monomer t...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90403-9
更新日期：1984-07-01 00:00:00
abstract：:Transcriptional regulation of gene expression is a key component of orchestrating proper immune cell development and function. One strategy for maintaining these transcriptional programs has been the evolution of transcription factor families with members possessing overlapping functions. Using the germ line deletion ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2015.02.009
更新日期：2015-05-01 00:00:00
abstract：:Enriched human B lymphocytes cocultivated with mouse L cells produced human leukocyte interferon (IFN-alpha) and shortly thereafter transferred antiviral activity to the recipient cells (99% inhibition of expected virus yield). In contrast, cocultivation of enriched T-cell populations with mouse L cells resulted in no...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90035-2
更新日期：1984-09-01 00:00:00
abstract：:Previous investigations have demonstrated a strain-associated differential susceptibility to herpes simplex virus-1 (HSV-1) infection in mice; C57BL/6 mice are more resistant to infection than BALB/c mice. Despite considerable research dealing with the immune response to HSV-1, relatively little attention has been pai...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1246
更新日期：1994-09-01 00:00:00
abstract：:Interleukin 4 (IL-4)-induced IgE production by normal peripheral blood mononuclear cells (PBMC) and E- cells (PBMC partially depleted of T cells) was significantly enhanced by leukotriene B4(LTB4) in a dose-dependent manner, whereas LTB4 by itself was not effective for IgE production. The potentiating effect of LTB4 w...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1158
更新日期：1994-06-01 00:00:00
abstract：:We examined the effects of the inhibitors of C1q or collagen biosynthesis, 2,2'-dipyridyl (DP), and 3,4-dehydro-DL-proline (DHP) on murine macrophage (M phi) FcR subclass-mediated antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis of sheep erythrocyte targets. Oil-elicited peritoneal M phi from C3HeB/FeJ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90062-1
更新日期：1987-03-01 00:00:00
abstract：:We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1142
更新日期：1994-05-01 00:00:00
abstract：:The oral administration of myelin basic protein (MBP) to Lewis rats prior to an encephalitogenic challenge resulted in total inhibition or a significant delay in the onset of experimental autoimmune encephalomyelitis (EAE). In vitro lymphocyte proliferative responses to MBP were significantly decreased in MBP-fed rats...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90305-x
更新日期：1988-04-01 00:00:00
abstract：:Ca(2+) and Sr(2+) entry pathways activated by pro-inflammatory agonists FMLP, LTB(4) and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10microM) increased Ca(2+) influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca(2+) beca...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.07.009
更新日期：2010-01-01 00:00:00
abstract：:Blockade of the immune cell checkpoint inhibitors programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) has become a powerful tool in cancer treatment, which is effective across various solid cancer types and hematologic malignancies. Our previous studies showed that by reducing immune tolerance, clustered r...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.09.003
更新日期：2017-10-01 00:00:00
abstract：:Medicinal plants are considered immunomodulatory as they display various biological activities. There is no report addressing the anti-inflammatory effects of Daphne gnidium. In this study, we investigated the effects of D. gnidium ethyl acetate (EA) leaf extract on mice immune cell function in vitro. Production of pr...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.12.002
更新日期：2011-01-01 00:00:00
