Abstract:
:We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/c mice (H-2d) and treated ip with 200 mg/kg CP 2 days later, BALB/c heart allografts were lasting in the recipients for as long as 8 weeks. On the other hand, B10 mice receiving either allogeneic spleen cells or CP rejected the heart allograft within 10 days after transplantation. A direct approach assessing the donor-reactive T cells for frequency and reactivity showed that the donor-reactive T cells were partially deleted and the rest were rendered unresponsive. CP-induced tolerance may be applied for the induction of antigen-specific tolerance to allogeneic heart transplantation.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Matsuura A,Katsuno M,Suzuki Y,Ito T,Yasuura K,Abe T,Yoshikai Ydoi
10.1006/cimm.1994.1142subject
Has Abstractpub_date
1994-05-01 00:00:00pages
501-7issue
2eissn
0008-8749issn
1090-2163pii
S0008-8749(84)71142-7journal_volume
155pub_type
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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doi:10.1016/j.cellimm.2009.01.010
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