Abstract:
:Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptible to the effects of aging. B cell function may also be altered with reduction in germinal center formation, antibody response, and affinity maturation of antibodies. Herein we showed that although antigen-specific antibody response to a soluble antigen declines in 18-month old mice, total levels of serum antibodies as well as frequencies of spleen and bone marrow antibody-producing cells are increased in aged mice. In addition, proliferative response of non-stimulated spleen T cells from aged mice were augmented and insensitive to increasing doses of concanavalin A stimulation as compared to young mice that showed a typical dose-dependent response to mitogen stimulation in vitro. These data suggest that the higher activation mode of B and T cells in senescent mice is a result of an increased frequency of cells committed to previous antigenic experiences and with poor ability to respond to novel antigenic challenges.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Speziali E,Santiago AF,Fernandes RM,Vaz NM,Menezes JS,Faria AMdoi
10.1016/j.cellimm.2009.01.010subject
Has Abstractpub_date
2009-01-01 00:00:00pages
1-5issue
1-2eissn
0008-8749issn
1090-2163pii
S0008-8749(09)00006-9journal_volume
256pub_type
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