Induction of CD8+ suppressor T cells by treatment with DMBA and TPA in vitro.

abstract：:The kinetics of viability of lymph node and spleen cells of mice genetically selected for "high" or "low" in vitro lymphocyte responsiveness to PHA were studied in PHA or PPD-stimulated short-term cultures. Lo/PHA cells were found to be less viable than Hi/PHA cells in unstimulated control cultures. PHA improved the v...

journal_title：Cellular immunology

authors： Stiffel C,Liacopoulos-Briot M,Decreusefond C,Lambert F

更新日期：1983-04-01 00:00:00

abstract：:Little is known about the role of signals transduced by cell surface IgM (sIgM) expressed during early B cell development. A subclone (1.6) of the late pre-B cell lymphoma 70Z/3.12 was used to study signal transduction by surface mu heavy (H) chain before and after transition to the early immature B cell stage, and th...

journal_title：Cellular immunology

authors： Tsutsumi A,Terajima J,Jung W,Ransom J

更新日期：1992-01-01 00:00:00

abstract：:We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory...

journal_title：Cellular immunology

authors： Masucci MG,Stam NJ,Torsteinsdottir S,Neefjes JJ,Klein G,Ploegh HL

更新日期：1989-05-01 00:00:00

abstract：:We describe here a culture system for studying the development, in vitro, of antigen-specific CD4 T cells from unprimed mice. T cells from young mice are initially exposed to antigen, such as pigeon cytochrome C or keyhole limpet hemocyanin, in the presence of adherent accessory cells and then allowed to proliferate i...

journal_title：Cellular immunology

authors： Dozmorov I,Miller RA

更新日期：1997-06-15 00:00:00

abstract：:The aim of this study was to clarify the role of IL-4, IL-10, IL-13 and interferon (IFN) -γ levels in atopic asthma patients by studying the relation between their serum levels and severity of the disease. The effect of IL-10 -1082G/A and IFN-γ +874T/A SNPs was also studied. The study included 200 atopic children with...

journal_title：Cellular immunology

authors： Hussein YM,Alzahrani SS,Alharthi AA,Ghonaim MM,Alhazmi AS,Eed EM,Shalaby SM

更新日期：2014-05-01 00:00:00

abstract：:Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral dsRNA, bacterial RNA, mitochondrial RNA, endogenous necrotic cell mRNA and the synthetic dsRNA an...

journal_title：Cellular immunology

authors： Duffy KE,Lamb RJ,San Mateo LR,Jordan JL,Canziani G,Brigham-Burke M,Korteweg J,Cunningham M,Beck HS,Carton J,Giles-Komar J,Duchala C,Sarisky RT,Mbow ML

更新日期：2007-08-01 00:00:00

abstract：:Heterotrimeric G-proteins control diverse biological processes by conveying signals from seven-transmembrane receptors to intracellular effectors. Although their signaling roles were originally ascribed to their GTP-bound alpha-subunits, more recent evidence points to the equally active roles played by their betagamma...

journal_title：Cellular immunology

authors： Dubeykovskiy A,McWhinney C,Robishaw JD

更新日期：2006-04-01 00:00:00

abstract：:Hybrid human-murine major histocompatibility antigens have been constructed and expressed on the surface of both human RD and murine L cell lines after DNA mediated gene transfer. These antigens linked the polymorphic domains (alpha 1 and alpha 2) of H-2Kb and the carboxy-terminal domains (alpha 3, transmembrane, and ...

journal_title：Cellular immunology

authors： Maziarz RT,Burakoff SJ,Reiss CS

更新日期：1986-04-15 00:00:00

abstract：:Imiquimod, a toll-like receptor 7 (TLR7) agonist, is an active pharmaceutical ingredient (API) established for the topical treatment of several dermal cancerous and precancerous skin lesions. Within this work, the immunostimulatory effect of imiquimod is further exploited in a transcutaneous immunization (TCI) approac...

journal_title：Cellular immunology

authors： Gogoll K,Stein P,Lee KD,Arnold P,Peters T,Schild H,Radsak M,Langguth P

更新日期：2016-10-01 00:00:00

abstract：:To improve the engraftment of human peripheral blood lymphocytes (PBL) to severe combined immunodeficient (SCID) mice, and to elucidate the factors which prevent the PBL's survival, we treated SCID mice with mAb, which neutralizes murine IFN-gamma's ability to activate cell-mediated immunity. Compared with untreated m...

journal_title：Cellular immunology

authors： Shibata S,Asano T,Noguchi A,Kimura H,Ogura A,Naiki M,Doi K

更新日期：1998-01-10 00:00:00

abstract：:The biochemical events leading to enhanced membrane expression of HLA-DR and CR3 by human peripheral blood monocytes (MO) following exposure to bacterial lipopolysaccharide (LPS) were examined. In a previous study we demonstrated that an increase in intracellular calcium was necessary, but not sufficient, for MO to in...

journal_title：Cellular immunology

authors： McLeish KR,Wellhausen SR,Dean WL

更新日期：1987-08-01 00:00:00

abstract：:Rat IL-2 produced by spleen cells in culture with concanavalin A was purified using gel filtration, hydrophobic chromatography, and ion-exchange chromatography. At least two forms of rat IL-2 were found to be separable by ion-exchange chromatography. These two forms have been designated form I and form II. Form I of r...

journal_title：Cellular immunology

authors： Thompson LP,Di Sabato G

更新日期：1988-06-01 00:00:00

abstract：:Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myelo...

journal_title：Cellular immunology

authors： Mundy-Bosse BL,Thornton LM,Yang HC,Andersen BL,Carson WE

更新日期：2011-01-01 00:00:00

abstract：:Recently we reported on a novel H2E transgenic, IA-negative model of experimental autoimmune thyroiditis (EAT) that excludes reactivity to self in its susceptibility pattern to heterologous thyroglobulin (Tg). In conventional, susceptible mouse strains, EAT is inducible with both homologous and heterologous Tg; e.g., ...

journal_title：Cellular immunology

authors： Yan Y,Panos JC,McCormick DJ,Wan Q,Giraldo AA,Brusic V,David CS,Kong YC

更新日期：2001-08-25 00:00:00

abstract：:The in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on the production and utilization of interleukin-2 (IL-2) by normal human peripheral blood mononuclear cells (PBMC) was evaluated by measuring IL-2 concentrations in supernatants from PHA-stimulated PBMC cultures. Drugs were ...

journal_title：Cellular immunology

authors： Viora M,Camponeschi B

更新日期：1995-07-01 00:00:00

abstract：:FOXP3+ regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to autoimmune, allergic, and other inflammatory disorders. Here, we review intuitive models regarding how T cell antigen receptor (TCR)...

journal_title：Cellular immunology

authors： Mannie MD,DeOca KB,Bastian AG,Moorman CD

更新日期：2020-09-01 00:00:00

abstract：:Murine 4-1BB is an approximately 30-kDa glycoprotein expressed on activated T cells and plays a role in T-cell-mediated proliferative response. To date the majority of work on 4-1BB has been conducted in the mouse. To assess the role of 4-1BB in humans, mAbs were made against the recombinant human (rh) 4-1BB protein. ...

journal_title：Cellular immunology

authors： Garni-Wagner BA,Lee ZH,Kim YJ,Wilde C,Kang CY,Kwon BS

更新日期：1996-04-10 00:00:00

abstract：:The cell-averaged microviscosity of intact murine peritoneal mononuclear phagocytes in various stages of activation was assessed by quantifying fluorescent depolarization of 1,6-diphenyl-1,3,5-hexatriene. Macrophages activated in vivo with Mycobacterium bovis, strain BCG, were significantly more fluid than resident pe...

journal_title：Cellular immunology

authors： Somers SD,Yuli I,Snyderman R,Adams DO

更新日期：1987-02-01 00:00:00

abstract：:To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7 days after oral challenge with a concomitant decrea...

journal_title：Cellular immunology

authors： Dourado LP,Noviello Mde L,Alvarenga DM,Menezes Z,Perez DA,Batista NV,Menezes GB,Ferreira AV,de Souza Dda G,Cara DC

更新日期：2011-01-01 00:00:00

abstract：:Blood and tissue eosinophilia is obtained when mice pretreated with cyclophosphamide (CY) and sensitized with picryl chloride are challenged on each ear lobe on day 13. To gain important insights into the cellular mechanisms involved in CY-induced eosinophilia in the contact-sensitivity reaction, we examined the cytok...

journal_title：Cellular immunology

authors： Sasaki G,Satoh T,Yokozeki H,Katayama I,Nishioka K

更新日期：2000-08-01 00:00:00

abstract：:Neoplastic thymocytes from rat thymic lymphoma-leukemias induced by the rat-adapted Gross leukemia virus (RAGV) were analyzed for a variety of differentiation markers. The neoplasms from individual rats all expressed the antigenic phenotype MP+, W3/13+, Thy-1+, RT-1+, RT-7+, W3/25-. However, approximately two-thirds o...

journal_title：Cellular immunology

authors： Barton RW,Greiner DL,Medlock ES,Goldschneider I

更新日期：1985-08-01 00:00:00

abstract：:Varying the concentration of anti-CD3 immobilized on Sepharose beads allowed us to study both the inhibitory and the stimulatory effects of IL-4 on purified T cells and contrast IL-4 versus IL-2-driven T-cell proliferative responses. In the presence of low density immobilized anti-CD3, IL-4 was unable to stimulate pur...

journal_title：Cellular immunology

authors： Jones-Tiffany LA,Mehrotra PT,Horohov DW,Siegel J,Kozak RW

更新日期：1993-04-01 00:00:00

abstract：:Using analogues of arginine to inhibit nitric oxide (NO.) production, investigators have demonstrated the intermediary role of NO. in a variety of physiological events including the antimicrobial activity exhibited by macrophages in vitro. In an effort to establish the effector function of NO. in the antimicrobial act...

journal_title：Cellular immunology

authors： Gregory SH,Sagnimeni AJ,Wing EJ

更新日期：1994-02-01 00:00:00

abstract：:Five thiol compounds including 2-mercaptoethanol (2-ME) were examined for their augmenting effects on in vitro antibody response to sheep erythrocytes. Three compounds were effective with the following order of activity; 2-ME greater than dithiothreitol greater than cysteamine. Glutathione and thioglycollate failed to...

journal_title：Cellular immunology

authors： Ohmori H,Yamamoto I

更新日期：1983-07-01 00:00:00

abstract：:We investigated the effects of prostaglandin E2 and IL-4 on the acquisition of cytokine-producing ability by naive CD4(+) T cells in human umbilical cord blood. The presence of PGE2 or IL-4 at primary stimulation inhibited the production of IFN-gamma at secondary stimulation, and the combination of these stimuli resul...

journal_title：Cellular immunology

authors： Abe N,Katamura K,Shintaku N,Fukui T,Kiyomasu T,Iio J,Ueno H,Tai G,Mayumi M,Furusho K

更新日期：1997-10-10 00:00:00

abstract：:Expression of certain autologous lymphocyte-activating antigenic determinants on the developing embryo is known to provide a stimulus for maternal anti-fetal autoproliferative responses. If left unregulated these responses could exert negative influences on the reproductive process by converting to autoaggressive form...

journal_title：Cellular immunology

authors： Hoskin DW,Gronvik KO,Hooper DC,Reilly BD,Murgita RA

更新日期：1989-04-15 00:00:00

abstract：:The antimicrobial peptide LL-37 is known to have a potent LPS-neutralizing activity in monocytes and macrophages. Recently, LL-37 in gingival crevicular fluids is suggested to be the major protective factor preventing infection of periodontogenic pathogens. In this study, we tried to address the effect of LL-37 on pro...

journal_title：Cellular immunology

authors： Into T,Inomata M,Shibata K,Murakami Y

更新日期：2010-01-01 00:00:00

abstract：AIMS:Non-enzymatic reaction of biomolecules leads to the formation of advanced glycation end products (AGEs). AGEs plays significant role in the pathophysiology of type 2 diabetes mellitus. Methylglyoxal (MG) is a highly reactive carbonyl compound which causes formation of early (ketoamines), intermediate (dicarbonyls)...

journal_title：Cellular immunology

authors： Khan MY,Alouffi S,Khan MS,Husain FM,Akhter F,Ahmad S

更新日期：2020-05-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) isolated from BALB/c mice bearing a B-cell leukemia (BCL1) showed a marked proliferative response upon two days culturing with poly(L-lysine) (PLL) of various molecular weights. An inverse relationship was noted between the molecular weight of the PLL and the dose required for optima...

journal_title：Cellular immunology

authors： Morecki S,Flechner Y,Slavin S

更新日期：1985-02-01 00:00:00

abstract：:The voltage gated potassium channel (Kv1.3) has been shown to play a role in immune responsiveness. Blockade of the channel led to diminution of T cell activation and delayed type hypersensitivity. Previous in vitro studies of the blockade were focused on T cell activation and proliferation. In this study we examined ...

journal_title：Cellular immunology

authors： Shah K,Tom Blake J,Huang C,Fischer P,Koo GC

更新日期：2003-02-01 00:00:00