Cytostatic effect of gangliosides present in the membrane of macrophages.

abstract：:We have recently demonstrated that estrogen has differential immunomodulatory properties in mice because it stimulates antibody responses but inhibits T cell-mediated inflammation. In the present study we have examined the influence of estrogen on T cell-independent inflammatory responses. A local inflammation was ind...

journal_title：Cellular immunology

authors： Josefsson E,Tarkowski A,Carlsten H

更新日期：1992-06-01 00:00:00

abstract：:Previous studies have shown that the anti-CD4 mAb W3/25 strongly enhances T cell APC (T-APC) activity. In this study, single positive CD4+ and double negative (DN) (CD4-CD8-) T-helper cells specific for the 55-69 or 72-86 sequence of guinea pig (GP) myelin basic protein (GPMBP) were used to study CD4 regulation of T-A...

journal_title：Cellular immunology

authors： Mannie MD,White GA,Nardella JP,Davidian DK,Arnold PY

更新日期：1998-06-15 00:00:00

abstract：:That M1/70, a monoclonal anti-murine macrophage antibody, recognizes murine natural killer cells (NK) and that there is an increase in NK following intraperitoneal infection with live Listeria monocytogenes (LM) was previously reported. Here, LM-induced NK cells were further characterized with respect to tumor target ...

journal_title：Cellular immunology

authors： Holmberg LA,Ault KA

更新日期：1984-11-01 00:00:00

abstract：:Murine C57BL/6 thymocytes were cultivated together with syngeneic thymus-derived macrophages (TDM phi) for up to 96 hr to determine whether TDM phi participate in thymocyte maturation. The expression level of H-2b and Thy-1.2 antigens served as thymocyte differentiation surface markers as analyzed by flow cytometry. I...

journal_title：Cellular immunology

authors： Zeira M,Gallily R,Stein I,Giloh H

更新日期：1991-05-01 00:00:00

abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

journal_title：Cellular immunology

authors： Shen C,Zhang J,Xia L,Meng F,Xie W

更新日期：2007-05-01 00:00:00

abstract：:Human K cells are able to lyse human lymphoblastoid B cells in the presence of specific anti-human immunoglobulin isotype antibodies. The human lymphoblastoid B-cell line DAUDI (surface mu- and kappa-chains positive) was lysed in the presence of anti-mu and anti-kappa antisera, or IgG fraction of these antisera, and B...

journal_title：Cellular immunology

authors： Caraux J,Weigle WO

更新日期：1983-03-01 00:00:00

abstract：:Many studies have shown that tumor necrosis factor (TNF) is a potent soluble mediator of immunoregulation and inflammation. Neuropeptide substance P (SP) has been known to exert significant influence on production of certain inflammatory cytokine by immune cells. Immunopathogenic mechanism underlying the effect of neu...

journal_title：Cellular immunology

authors： Nair MP,Schwartz SA

更新日期：1995-12-01 00:00:00

abstract：:Chinese hamster ovary (CHO) cells are commonly used in the generation of transfectants for use in in vitro costimulation assays. However, we have noted that nontransfected CHO cells can themselves provide a low-level B7/CD28 independent costimulatory signal for CD3-mediated murine T cell activation and IL-2 production...

journal_title：Cellular immunology

authors： Gaglia JL,Mattoo A,Greenfield EA,Freeman GJ,Kuchroo VK

更新日期：2001-11-01 00:00:00

abstract：:Older humans and experimental animals have been repeatedly found to have higher titers of autoantibodies than do younger individuals despite the impaired responses of older individuals to foreign antigens. The studies reported here were designed to examine the relationship between these two age-related changes in anti...

journal_title：Cellular immunology

authors： Bovbjerg DH,Kim YT,Schwab R,Schmitt K,DeBlasio T,Weksler ME

更新日期：1991-07-01 00:00:00

abstract：:The mechanism by which purinergic agonists modulate murine T-lymphocyte activation and proliferation was investigated. Adenosine and other compounds such as ATP and 2-chloroadenosine (ClAdo) were found to block T-cell mitogenesis induced by concanavalin A (Con A) in a dose-dependent fashion. The nonmetabolizable adeno...

journal_title：Cellular immunology

authors： DosReis GA,Nóbrega AF,de Carvalho RP

更新日期：1986-08-01 00:00:00

abstract：:Many studies have already been reported with regard to the serological cross-reactivities between the polymorphic determinants of murine Ia antigens and human HLA-DR antigens. In this paper, we examined the biological cross-reactivity of the polymorphism of Class II antigens in the xenogeneic antigen-presenting cell (...

journal_title：Cellular immunology

authors： Yamamoto M,Yano A

更新日期：1984-09-01 00:00:00

abstract：:Platelet-activating factor (PAF) has previously been shown to stimulate intracellular signal transductional events similar to the macrophage tumoricidal activators interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Macrophages stimulated with IFN-gamma and LPS utilize various cytolytic mediators in order to ki...

journal_title：Cellular immunology

authors： Howard AD,Erickson KL

更新日期：1995-08-01 00:00:00

abstract：:Gene products coded for within the HLA complex play an important role in the control of immune responses. Class I antigens, coded for by the HLA-A, B, and C loci, are expressed by virtually all mononuclear blood cells. Class II antigens, coded for by the DR, DQ, and DP loci, have a more limited tissue distribution. Th...

journal_title：Cellular immunology

authors： Zier KS

更新日期：1986-07-01 00:00:00

abstract：:Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifyi...

journal_title：Cellular immunology

authors： Seifert HA,Benedek G,Liang J,Nguyen H,Kent G,Vandenbark AA,Saugstad JA,Offner H

更新日期：2017-08-01 00:00:00

abstract：:Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulate...

journal_title：Cellular immunology

authors： Pradhananga S,Spalinskas R,Poujade FA,Eriksson P,Sahlén P

更新日期：2020-09-01 00:00:00

abstract：:Effects of pertussis toxin (PT) on sensitized T-cell populations for delayed-type hypersensitivity (DTH) were examined in mice. DTH was induced by sensitizing mice with ovalbumin (OA) and elicited by injecting OA into the footpad. DTH could be conferred on naive recipient mice by injecting sensitized spleen cells eith...

journal_title：Cellular immunology

authors： Tamura SI,Nakanishi Y,Kojima A,Otokawa M,Uchida N,Sato H,Sato Y

更新日期：1984-05-01 00:00:00

abstract：:Although ligation of the T-cell antigen receptor (TCR) is central to the responsiveness and antigen specificity of T-cells, it is insufficient to elicit a response. To determine whether the need for costimulation reflects inadequate strength of signal transduction through the TCR or an absolute block of signaling in t...

journal_title：Cellular immunology

authors： Adler B,Ashkar S,Cantor H,Weber GF

更新日期：2001-05-25 00:00:00

abstract：:The activities of the enzymes involved in purine nucleoside metabolism, adenosine deaminase (ADA), adenosine kinase (AK), purine nucleoside phosphorylase (PNP) and deoxycytidine kinase (deoxyCRK), were determined in mouse thymocytes at various stages of differentiation and maturation, and compared with those in other ...

journal_title：Cellular immunology

authors： Kizaki H,Habu S,Ohsaka F,Sakurada T

更新日期：1983-12-01 00:00:00

abstract：:Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with Corynebacterium parvum. These immune splenocytes could b...

journal_title：Cellular immunology

authors： Chang AE,Perry-Lalley DM,Shu S

更新日期：1989-05-01 00:00:00

abstract：:Although engagement of MHC class II molecules on human monocytes triggers various cellular events, their possible role in monocyte death is yet unknown. We demonstrate that ligation of MHC class II on primary monocytes induces a rapid cell death that has all the characteristics of monocyte apoptosis, does not require ...

journal_title：Cellular immunology

authors： Thibeault A,Zekki H,Mourad W,Charron D,Al-Daccak R

更新日期：1999-02-25 00:00:00

abstract：:To characterize the binding properties of the Fc receptors on human macrophages, the binding of radiolabeled human IgG1 to peritoneal macrophages was assessed. Cells were obtained at the time of diagnostic laparoscopy from women undergoing evaluation of infertility. Macrophages bound on the average more IgG1 monomer t...

journal_title：Cellular immunology

authors： Kurlander RJ,Haney AF,Gartrell J

更新日期：1984-07-01 00:00:00

abstract：:Inhibitors of energy metabolism, 2-deoxyglucose and cyanide were shown to inhibit NKCF-mediated lysis of L929 target cells at the same molar concentrations that effectively inhibited cellular ATP levels and the toxic effects of pseudomonas toxin A. In addition, inhibitors of receptor-mediated endocytosis, cytochalasin...

journal_title：Cellular immunology

authors： Deem RL,Niederlehner A,Targan SR

更新日期：1986-10-01 00:00:00

abstract：:Cells from the spleen, lymph nodes, and peritoneum of DBA/2 mice bearing a subcutaneous tumor mediate nonspecific suppression of an in vitro antibody response to sheep red blood cells (SRBC) when cocultured with a normal T-cell subset(s). The spleen cells from the tumor-bearing mouse required for the suppression bear ...

journal_title：Cellular immunology

authors： Ingenito GG,Calkins CE

更新日期：1983-07-01 00:00:00

abstract：:The purpose of this study was to determine whether multiple types of suppressor factors play a role in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes (UV Ts). The UV Ts were induced by applying contact allergens to the ventral, unirradiated skin of mice exposed 5 days earl...

journal_title：Cellular immunology

authors： Yee GK,Ullrich SE,Kripke ML

更新日期：1989-06-01 00:00:00

abstract：:C3H/HeJ mice are homozygous for the Lpsd allele and, as a consequence, are hyporesponsive to all of the biological effects of bacterial lipopolysaccharide (LPS) that have been studied. These mice die in the early phase of infection when inoculated with virulent Salmonella. This susceptibility is also regulated by the ...

journal_title：Cellular immunology

authors： Weinstein DL,Lissner CR,Swanson RN,O'Brien AD

更新日期：1986-10-01 00:00:00

abstract：:The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-...

journal_title：Cellular immunology

authors： Kato T,Nishida T,Ito Y,Murase M,Murata M,Naoe T

更新日期：2014-03-01 00:00:00

abstract：:T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...

journal_title：Cellular immunology

authors： Ando DG,Clayton J,Kono D,Urban JL,Sercarz EE

更新日期：1989-11-01 00:00:00

abstract：:A B lymphoblastoid cell line can provide a comitogenic, accessory signal for mitogen-treated T cells. In a study evaluating the antigenic determinant of such cells that mediate this effect, a monoclonal antibody (I57) was raised against the Daudi cell line. This antibody was found to interact with a 30-kDa protein on ...

journal_title：Cellular immunology

authors： Hardy B,Dotan D,Novogrodsky A

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:We aim to evaluate the effects of atorvastatin on the expression of Toll-like receptor (TLR4) protein and mRNA, and to explore their effects on TLR4-dependent downstream signaling in human monocytic leukemia (THP-1) cells. METHODS:TLR4 protein and mRNA expression, levels of NF-κB protein, and expression of TNF...

journal_title：Cellular immunology

authors： Yang SS,Li R,Qu X,Fang W,Quan Z

更新日期：2012-09-01 00:00:00

abstract：:The lymphokine IL-4 is a potent enhancer of anti-IgM-induced B cell proliferation. Although the mechanism of this enhancement is not known, a commonly held view suggests that IL-4 acts together with anti-IgM as a costimulating factor for the activation of a subpopulation of B cells. To evaluate this hypothesis we exam...

journal_title：Cellular immunology

authors： Hodgkin PD,Go NF,Cupp JE,Howard M

更新日期：1991-04-15 00:00:00