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Induction of tumor antigen-specific cytotoxic T cell responses in naïve mice by latex microspheres-based artificial antigen-presenting cell constructs.

Abstract：

:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD28 monoclonal antibody onto surface of cell-sized latex microspheres followed by immunization of naïve HLA-A2/K(b) transgenic mice. Five- to six-fold expansion of tumor antigen-specific CTLs was observed in the spleen after three rounds of immunization. The consequent splenocytes can efficiently recognize endogenously expressed tumor antigen on the surface of human target cells and cytolyze the tumor cells in an antigen-specific manner. This report provides initially the experimental evidence that latex microspheres-based aAPCs can effectively prime antigen-specific CTL proliferation and cytolysis in naïve mice. This may contribute to a better insight into the potential of microspheres-based aAPCs for active immunization.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Shen C,Zhang J,Xia L,Meng F,Xie W

doi

10.1016/j.cellimm.2007.07.002

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

28-35

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(07)00153-0

journal_volume

247

pub_type

杂志文章

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