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Serological and biological cross-reactivity of class II antigens between mice and humans in antigen-specific T-cell proliferative responses.

Abstract：

:Many studies have already been reported with regard to the serological cross-reactivities between the polymorphic determinants of murine Ia antigens and human HLA-DR antigens. In this paper, we examined the biological cross-reactivity of the polymorphism of Class II antigens in the xenogeneic antigen-presenting cell (APC)-T-cell interaction. The data indicate that purified protein derivative (PPD)-specific human T cells were not stimulated by PPD-pulsed murine APC from B10.S(9R) which possess I-As and I-Ek molecules serologically cross-reacting with human Class II antigens. On the contrary, B10.S(9R) T cells primed to PPD were stimulated by PPD-pulsed human APC. The failure of the murine APC-human T-cell interaction was not caused by the suppressive effect in culture with ongoing xenogeneic mixed lymphocyte reactions (MLR) or other cell culture conditions. Thus, a hierarchy of antigen-presenting ability in the xenogeneic APC-T-cell interaction was shown to exist.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Yamamoto M,Yano A

doi

10.1016/0008-8749(84)90033-9

subject

Has Abstract

pub_date

1984-09-01 00:00:00

pages

659-73

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(84)90033-9

journal_volume

87

pub_type

杂志文章

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