Substance P induces tumor necrosis factor in an ex vivo model system.

abstract：:The role of lymphostromal complexes in T-cell differentiation is far from elucidated, mainly because a clear association of a particular stromal cell type with a distinct thymocyte subset has never been identified. Using an in vitro system, detecting the adherence of thymocytes to a thymic medullary epithelial cell li...

journal_title：Cellular immunology

authors： Hugo P,Potworowski EF

更新日期：1990-03-01 00:00:00

abstract：:T lymphocytes respond to mitogenic stimulation by expressing the receptor for interleukin 2 (Il-2) and secreting Il-2; once the receptor is expressed, Il-2 induces these cells to proliferation. In the present report using mouse T lymphocytes, thymocytes, and the lymphoma cell line EL4, we studied receptor expression a...

journal_title：Cellular immunology

authors： Truneh A,Simon P,Schmitt-Verhulst AM

更新日期：1986-12-01 00:00:00

abstract：:When guinea pigs were treated by complete Freund's adjuvant (CFA), eosinophil-directed chemotactic inhibitory factor (ECIF) appeared in the serum of the treated animals. The inhibition of the response of eosinophils by ECIF was selective for the T cell-derived chemotactic factor, which has been isolated from DNP-ascar...

journal_title：Cellular immunology

authors： Hirashima M,Tashiro K,Hayashi H

更新日期：1984-11-01 00:00:00

abstract：:Previous investigations have demonstrated a strain-associated differential susceptibility to herpes simplex virus-1 (HSV-1) infection in mice; C57BL/6 mice are more resistant to infection than BALB/c mice. Despite considerable research dealing with the immune response to HSV-1, relatively little attention has been pai...

journal_title：Cellular immunology

authors： Brenner GJ,Cohen N,Moynihan JA

更新日期：1994-09-01 00:00:00

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:We studied the effect of vasoactive intestinal peptide (VIP), somatostatin (SOM), and substance P (SP) on IL-4-stimulated human IgE and IgG subclass production. VIP and SOM, but not SP, inhibited IgE production without affecting IgM or IgA production by mononuclear cells (MNC) from nonatopic donors from 10 pM to 10 nM...

journal_title：Cellular immunology

authors： Kimata H,Yoshida A,Ishioka C,Mikawa H

更新日期：1992-10-15 00:00:00

abstract：:Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

journal_title：Cellular immunology

authors： Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

更新日期：2013-02-01 00:00:00

abstract：:In this study, the major histocompatibility complex-unrestricted cytotoxic effectors elicited in human peripheral blood mononuclear cells (PBMC) by a mannoprotein (MP) component from the cell wall of the human indigenous microorganism Candida albicans have been compared with those obtained by stimulation with interleu...

journal_title：Cellular immunology

authors： Ausiello CM,Palma C,Spagnoli GC,Piazza A,Casciani CU,Cassone A

更新日期：1989-07-01 00:00:00

abstract：:We previously showed that DT-5461a, a lipid A analog, has antitumor activity and relatively low toxicity in animals. To clarify its immunostimulatory effect we have studied the cytokine inducibility of DT-5461a and the mechanism involved in the cytokine expression in macrophages. While the activity is lower than that ...

journal_title：Cellular immunology

authors： Akahane K,Someya K,Tsutomi Y,Akimoto T,Tohgo A

更新日期：1994-04-15 00:00:00

abstract：:Optical imaging is a valuable tool to visualise biological processes in the context of the tissue. Each imaging modality provides the biologist with different types of information - cell dynamics and migration over time can be tracked with time-lapse imaging (e.g. intra-vital imaging); an overview of whole tissues can...

journal_title：Cellular immunology

authors： Husna N,Gascoigne NRJ,Tey HL,Ng LG,Tan Y

更新日期：2019-10-01 00:00:00

abstract：:Adoptive immunotherapy is a promising cancer treatment that entails infusion of immune cells manipulated to have antitumor specificity, in vitro. Antigen-specific cytotoxic T lymphocytes are the main executors of transformed cells during cancer immunotherapy. To induce antigen-specific cytotoxic T lymphocytes, we deve...

journal_title：Cellular immunology

authors： Shao J,Xu Q,Su S,Wei J,Meng F,Chen F,Zhao Y,Du J,Zou Z,Qian X,Liu B

更新日期：2018-12-01 00:00:00

abstract：:A low culture temperature of 27 degrees C inhibited mouse primary in vitro anti-hapten plaque-forming cell responses to a thymus-dependent (TD) antigen (Ag) (trinitrophenyl-keyhole limpet hemocyanin, TNP-KLH). In contrast, the magnitudes of secondary responses to TNP-KLH or primary responses to a thymus-independent (T...

journal_title：Cellular immunology

authors： Wang-Yang MC,Buttke TM,Miller NW,Clem LW

更新日期：1990-04-01 00:00:00

abstract：:Curcumin has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In the present study, the effect of curcumin on allergic responses in ovalbumin (OVA)-induced allergic rhinitis mouse was investigated. We explored the effect...

journal_title：Cellular immunology

authors： Zhang N,Li H,Jia J,He M

更新日期：2015-11-01 00:00:00

abstract：:We tested the contribution of four staphylococcal components - PSM-α, PSM-β, δ-toxin, and PVL - in triggering macrophage secretion of tumor necrosis factor (TNF) and interleukins 6 (IL-6) and 12 (IL-12) by two prominent, circulating strains of community-associated, methicillin-resistant Staphylococcus aureus (CA-MRSA)...

journal_title：Cellular immunology

authors： Spentzas T,Kudumula R,Acuna C,Talati AJ,Ingram KC,Savorgnan F,Meals EA,English BK

更新日期：2011-01-01 00:00:00

abstract：:The role of macrophages (M phi) and that of splenic dendritic cells (DC) in the allogeneic mixed leukocyte reaction (MLR) in the mouse have been investigated. In contrast with the high stimulatory capacity of DC, we obtained no evidence in favor of the competence of M phi, whether Ia + or Ia-, as an autonomous stimula...

journal_title：Cellular immunology

authors： Naito K,Komatsubara S,Kawai J,Mori K,Muramatsu S

更新日期：1984-10-15 00:00:00

abstract：:Homozygosity for either the lpr (lymphoproliferation) or the gld (generalized lymphoproliferative disease) mutation in mice causes the development of strikingly similar hyperglobulinemia and lymphoproliferative syndromes. Nevertheless, previous studies of various C57BL/6 chimeras obtained by reconstitution of irradiat...

journal_title：Cellular immunology

authors： Velin D,Goettelfinger P,Froidevaux S,Loor F

更新日期：1993-05-01 00:00:00

abstract：:Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate...

journal_title：Cellular immunology

authors： Tang R,Langdon WY,Zhang J

更新日期：2019-06-01 00:00:00

abstract：:We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex...

journal_title：Cellular immunology

authors： Sun D,Krishnan A,Su J,Lawrence R,Zaman K,Fernandes G

更新日期：2004-03-01 00:00:00

abstract：:PICOT (PKC-interacting cousin of thioredoxin) consists of one thioredoxin homology domain in the N-terminal and two tandem PICOT homology domains in the C-terminal. PICOT specifically interacts with protein kinase C theta (PKC-theta) via its thioredoxin homology domain and acts as an important modulator of T cell rece...

journal_title：Cellular immunology

authors： Kato N,Motohashi S,Okada T,Ozawa T,Mashima K

更新日期：2008-01-01 00:00:00

abstract：:Mucus production by goblet cells in the gastrointestinal tract following Salmonella typhimurium infection using a ligated ileal loop model in mice was investigated. Assessment of the morphology of the loop tissue after Salmonella challenge revealed generalized tissue inflammation, characterized by edema and an inflamm...

journal_title：Cellular immunology

authors： Arnold JW,Klimpel GR,Niesel DW

更新日期：1993-10-15 00:00:00

abstract：:The antimicrobial peptide LL-37 is known to have a potent LPS-neutralizing activity in monocytes and macrophages. Recently, LL-37 in gingival crevicular fluids is suggested to be the major protective factor preventing infection of periodontogenic pathogens. In this study, we tried to address the effect of LL-37 on pro...

journal_title：Cellular immunology

authors： Into T,Inomata M,Shibata K,Murakami Y

更新日期：2010-01-01 00:00:00

abstract：:Stroke is the leading cause of disability in the United States. Sex differences, including smaller infarcts in females and greater involvement of immune-mediated inflammation in males may affect the efficacy of immune-modulating interventions. To address these differences, we sought to identify distinct stroke-modifyi...

journal_title：Cellular immunology

authors： Seifert HA,Benedek G,Liang J,Nguyen H,Kent G,Vandenbark AA,Saugstad JA,Offner H

更新日期：2017-08-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DP IV, CD26), known as an activation marker of T lymphocytes, is a proline-specific protease thought to be involved in the regulation of the immune response. The physiological role of dipeptidyl peptidase IV in the immune system and the molecular events of lymphocyte activation mediated by thi...

journal_title：Cellular immunology

authors： Kähne T,Kröning H,Thiel U,Ulmer AJ,Flad HD,Ansorge S

更新日期：1996-05-25 00:00:00

abstract：:To determine whether human antibody responses to T cell-independent pneumococcal polysaccharide antigens are derived from CD5+ or CD5- B cells, we utilized an ELISPOT assay to detect individual anti-polysaccharide antibody-secreting cells. Human anti-type IV pneumococcal polysaccharide antibody-secreting cells were fo...

journal_title：Cellular immunology

authors： Barrett DJ,Sleasman JW,Schatz DA,Steinitz M

更新日期：1992-08-01 00:00:00

abstract：:Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses of control mice (Ehr) presented giant tumor cells and many mitotic figures whereas the tumor ti...

journal_title：Cellular immunology

authors： Pinto AV,Martins PR,Romagnoli GG,Campanelli AP,Terezan AP,Filho ER,Ferreira da Eira A,Kaneno R

更新日期：2009-01-01 00:00:00

abstract：:A series of Lyt 2+, trinitrophenyl (TNP)-specific T-cell lines are shown to lyse 51Cr-labeled target cells in an antigen-specific, H-2-restricted fashion in a 4-hr assay. These cells also produce lymphotoxin, in addition to other factors, upon stimulation with TNP-haptenated syngeneic splenocytes. A technique for intr...

journal_title：Cellular immunology

authors： Schmid DS,Powell MB,Mahoney KA,Ruddle NH

更新日期：1985-06-01 00:00:00

abstract：:In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...

journal_title：Cellular immunology

authors： Leghmari K,Contreras X,Moureau C,Bahraoui E

更新日期：2008-01-01 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, played an important role in immune-mediated diseases. The promoter region of MIF, which had functional polymorphisms, controlled MIF expression. MIF polymorphism was associated with many inflammatory diseases. But the association of MIF polymor...

journal_title：Cellular immunology

authors： Zhang K,Pan X,Shu X,Cao H,Chen L,Zou Y,Deng H,Li G,Xu Q

更新日期：2013-04-01 00:00:00

abstract：:Seeking common abnormalities in mice genetically predisposed to lupus-like autoimmune disease, we investigated (1) the ontogeny of Ia antigens (I-A/I-E) on the surfaces of resident peritoneal macrophages (rpM phi) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of M phi-stimulating fac...

journal_title：Cellular immunology

authors： Kofler R,Schreiber RD,Dixon FJ,Theofilopoulos AN

更新日期：1984-08-01 00:00:00

abstract：:Chronic allotype suppression was generated in M-1 (C mu), G-1 (C gamma) heterozygous B14 line chickens either by embryonal injection or by maternal transfer of anti-M-1b allotype antibodies. Using a sensitive radioimmunoassay to detect the suppressed IgM-1b, a striking disparity was observed between the degree of supp...

journal_title：Cellular immunology

authors： Ratcliffe MJ

更新日期：1984-01-01 00:00:00