Selection of CD4+CD8+ thymocytes by complex formation with medulla-derived epithelial cells.

abstract：:Interleukins play a role in the process of T-cell development and, like other cytokines, seem able to modulate apoptosis. Interleukin-2 has been reported to inhibit apoptotic cell death of thymocytes induced in vitro by either activation of CD3/TCR complex or treatment with glucocorticoid hormone. We demonstrate here ...

journal_title：Cellular immunology

authors： Migliorati G,Nicoletti I,Pagliacci MC,D'Adamio L,Riccardi C

更新日期：1993-01-01 00:00:00

abstract：:FOXP3+ regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to autoimmune, allergic, and other inflammatory disorders. Here, we review intuitive models regarding how T cell antigen receptor (TCR)...

journal_title：Cellular immunology

authors： Mannie MD,DeOca KB,Bastian AG,Moorman CD

更新日期：2020-09-01 00:00:00

abstract：:Previous work in our laboratory established that individual complement components can be regulated in vivo by administration of specific antibody or immunocompetent cells to newborns and in vitro by administration of specific antibody to cultured peritoneal macrophages or splenic fragments. Antibody-induced suppressio...

journal_title：Cellular immunology

authors： Goldman JN,O'Rourke KS,Goldman MB

更新日期：1985-11-01 00:00:00

abstract：:Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis share the same acquired genetic lesion, JAK2V617F. It is believed that cytokines participate in the activation of JAK2V617F. In this study, we analyzed the plasma levels of interleukin (IL)-23, IL-10 and IL-22 in patients with PV and ET. In the s...

journal_title：Cellular immunology

authors： Gangemi S,Allegra A,Pace E,Alonci A,Ferraro M,Petrungaro A,Saitta S,Gerace D,Russo S,Penna G,Musolino C

更新日期：2012-07-01 00:00:00

abstract：:Possible causes were examined for the inability of heat-inactivated lymphocytes to induce proliferative responses in mixed-lymphocyte cultures (MLC). Cells heated at 45 degrees C for 60 min lost greater than 90% of their capacity to stimulate in primary (1 degree) or secondary (2 degrees) MLC. This was not due to acce...

journal_title：Cellular immunology

authors： Boyer CM,Kostyu DD,Brissette CS,Amos DB

更新日期：1986-09-01 00:00:00

abstract：:Psoriasis is a common dermatosis mediated by T cells. This study investigated the correlation of Th22 cells and Tc22 cells with psoriasis. A total of 30 psoriasis patients and 11 age- and sex-matched healthy controls were recruited for this study. The proportions of circulating Th22 and Tc22 cells, expression of aryl ...

journal_title：Cellular immunology

authors： Luan L,Ding Y,Han S,Zhang Z,Liu X

更新日期：2014-08-01 00:00:00

abstract：:The molecular mechanism responsible for the age-dependent decline of natural killer (NK) cell response was examined. The responses of NK cells to poly(I:C), Con A, and LPS were compared between the young and the aged animals. We observed that both basal and induced NK cell activity declined with age. To further determ...

journal_title：Cellular immunology

authors： Hsueh CM,Chen SF,Ghanta VK,Hiramoto RN

更新日期：1996-11-01 00:00:00

abstract：:Idiotope-specific immunoenhancement or suppression was induced in C57BL/6 mice by the injection of physiological amounts (100 ng-10 micrograms) of monoclonal anti-idiotope antibody. As previously described, nanogram doses enhanced idiotope expression while a 10-micrograms dose of anti-idiotope antibody induced the act...

journal_title：Cellular immunology

authors： Kelsoe G

更新日期：1986-03-01 00:00:00

abstract：:Our earlier studies revealed that a rapid and progressive loss of splenic NK activity in mice during the development of a number of transplanted tumors as well as of spontaneous tumors was due to an inactivation of natural killer (NK) lineage cells rather than to their disappearance. The mechanism of this inactivation...

journal_title：Cellular immunology

authors： Parhar RS,Lala PK

更新日期：1985-07-01 00:00:00

abstract：:Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses of control mice (Ehr) presented giant tumor cells and many mitotic figures whereas the tumor ti...

journal_title：Cellular immunology

authors： Pinto AV,Martins PR,Romagnoli GG,Campanelli AP,Terezan AP,Filho ER,Ferreira da Eira A,Kaneno R

更新日期：2009-01-01 00:00:00

abstract：:We have investigated the role of interleukin-2 (IL2) as a differentiation factor for human marrow-derived NK cell progenitors and have assessed the effects of interleukin-1 (IL1) on this activity. The effects of these cytokines on early NK cell precursors was determined by testing marrow which had been depleted of mat...

journal_title：Cellular immunology

authors： Keever CA,Pekle K,Gazzola MV,Collins NH,Gillio A

更新日期：1990-03-01 00:00:00

abstract：:This study aimed to describe the vascular and cellular histopathological changes that occurred in post-mastectomy seroma in an animal model. Unilateral mastectomies were conducted on 45 female albino rabbits. On day seven, the skin flap and the underlying tissues of the mastectomy regions were dissected and processed ...

journal_title：Cellular immunology

authors： Al-Gaithy ZK,Ayuob NN

更新日期：2012-01-01 00:00:00

abstract：:The aim of our work was to study apoptosis as a possible mechanism of CD4+ lymphocyte depletion in AIDS patients and to test whether IL-12 could limit this phenomenon. As an in vitro model, we used a human IL-2-dependent Th1 clone from an uninfected individual. We found that CD4 cross-linking, obtained either by mouse...

journal_title：Cellular immunology

authors： Radrizzani M,Accornero P,Amidei A,Aiello A,Delia D,Kurrle R,Colombo MP

更新日期：1995-03-01 00:00:00

abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

journal_title：Cellular immunology

authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

更新日期：1995-05-01 00:00:00

abstract：:Previous studies established that low in vitro temperatures (27 degrees C, termed nonpermissive) suppressed murine primary thymus-dependent (TD), but not primary thymus-independent (TI) or secondary TD, antibody responses. Suppression was rescued by the addition of oleic acid (18:1), recombinant interleukin (rIL)-2 an...

journal_title：Cellular immunology

authors： Wooten RM,Clem LW,Bly JE

更新日期：1993-11-01 00:00:00

abstract：:Complete T cell activation requires not only a first signal via TCR/CD3 engagement but also a costimulatory signal through accessory receptors such as CD2, CD28, or integrins. Focal adhesion kinase, pp125(FAK) (FAK), was previously shown to be localized in focal adhesions in fibroblasts and to be involved in integrin-...

journal_title：Cellular immunology

authors： Tabassam FH,Umehara H,Huang JY,Gouda S,Kono T,Okazaki T,van Seventer JM,Domae N

更新日期：1999-05-01 00:00:00

abstract：:Development of contact hypersensitivity in mice depends on the migration of Langerhans cells from the epidermis to regional lymph nodes. Since ICAM-1 and LFA-1 play important roles in leukocyte migration, we sought to determine whether in vivo administration of anti-ICAM-1 and anti-LFA-1 antibodies would inhibit conta...

journal_title：Cellular immunology

authors： Ma J,Wang JH,Guo YJ,Sy MS,Bigby M

更新日期：1994-10-15 00:00:00

abstract：:Short-term culture of murine lymphocytes in interleukin 2 (IL-2), in the absence of any priming antigen, has been shown to result in the differentiation of an activated killer cell population capable of potent cytotoxic activity against tumor cells. The progenitor and lineage of these lymphokine activated killer cells...

journal_title：Cellular immunology

authors： Owen-Schaub LB,Abraham SR,Hemstreet GP 3rd

更新日期：1986-12-01 00:00:00

abstract：:PIM kinases are a family of three serine/threonine kinases expressed following T cell activation. Using potent selective small molecule antagonists of PIM-1/3 kinases, we demonstrate a potential role for these enzymes in naïve and effector CD4+ T cell activation. PIM-1/3 inhibition prevented CD4+ T cell proliferation ...

journal_title：Cellular immunology

authors： Jackson LJ,Pheneger JA,Pheneger TJ,Davis G,Wright AD,Robinson JE,Allen S,Munson MC,Carter LL

更新日期：2012-01-01 00:00:00

abstract：:The impact of BCR:CD21 co-engagement on B cell expression of molecules critical for T cell activation was investigated with receptor-specific mAbs conjugated to high MW dextran as stimulatory ligands. In the absence of IL-4, BCR:CD21 co-ligation augmented BCR-triggered CD86 only under conditions of very low BCR ligand...

journal_title：Cellular immunology

authors： Mongini PK,Tolani S,Fattah RJ,Inman JK

更新日期：2002-03-01 00:00:00

abstract：:The antifungal activity of nonactivated resident murine peritoneal macrophages for Cryptococcus neoformans was studied. Macrophages from five of six mouse strains tested had significant (40 to 80%) fungistatic activity, depending on the inoculum size, in a 24-hr coculture system. Macrophages from two outbred (SW and I...

journal_title：Cellular immunology

authors： Brummer E,Stevens DA

更新日期：1994-08-01 00:00:00

abstract：:The purpose of the present study was to compare the phenotype of tissue macrophages with that of their precursors in the bone marrow and blood. The phenotype was determined on the basis of the quantitative binding of monoclonal antibodies to cell-surface antigens (antigen F4/80, complement receptor III, Fc receptor II...

journal_title：Cellular immunology

authors： Nibbering PH,Leijh PC,van Furth R

更新日期：1987-04-01 00:00:00

abstract：:The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

journal_title：Cellular immunology

authors： Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

更新日期：1992-10-15 00:00:00

abstract：:Viruses are related to the etiology of periodontitis. However, the role of viruses on Th17 cells infiltration in periodontitis lesions is unknown. Therefore, we examined the effects of TLR3 ligand on CCL20, which is related to Th17 cells migration, production in human gingival fibroblasts (HGFs). Polyinosinic-polycyti...

journal_title：Cellular immunology

authors： Hosokawa Y,Hosokawa I,Shindo S,Ozaki K,Matsuo T

更新日期：2013-05-01 00:00:00

abstract：:The purpose of this study was to determine whether multiple types of suppressor factors play a role in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes (UV Ts). The UV Ts were induced by applying contact allergens to the ventral, unirradiated skin of mice exposed 5 days earl...

journal_title：Cellular immunology

authors： Yee GK,Ullrich SE,Kripke ML

更新日期：1989-06-01 00:00:00

abstract：:Tegumentary leishmaniasis (TL) constitutes a major public health problem with significant morbidity worldwide. Synthetic peptide-based vaccines are attractive candidates to protect against leishmaniasis, since T cell-specific epitopes can be delivery to antigen-presenting cells, leading to the generation of a Th1 cell...

journal_title：Cellular immunology

authors： Martins VT,Lage DP,Duarte MC,Carvalho AM,Costa LE,Mendes TA,Vale DL,Menezes-Souza D,Roatt BM,Tavares CA,Soto M,Coelho EA

更新日期：2017-03-01 00:00:00

abstract：:Dendritic cells (DC), as professional antigen presenting cells, play the central role in the process of body initiating the anti-tumor immunity, and the study on DC anti-tumor vaccine has become heated in recent years. In this study, we used polyethylene glycol (PEG) to induce renal cell carcinoma (RCC) 786-O cell lin...

journal_title：Cellular immunology

authors： Hu Z,Liu S,Mai X,Hu Z,Liu C

更新日期：2010-01-01 00:00:00

abstract：:CD20 is expressed strictly by B-cells and is ubiquitously expressed at high surface densities of malignant human B-cells. This suggests that CD20 may be a tumor target for immunotherapy of B-cell lymphomas. Rituximab, a chimeric monoclonal antibody directed against CD20, has been demonstrated to be an effective treatm...

journal_title：Cellular immunology

authors： Li M,Yan Z,Han W,Zhang Y

更新日期：2006-02-01 00:00:00

abstract：:Micromolar amounts of SV-IV, one of the major proteins secreted from the rat seminal vesicle epithelium, induce in vitro a marked release of a variety of cytokines (interferon-gamma, tumor necrosis factor-alpha, interleukin 6, and granulocyte-monocyte colony-stimulating factor) from human resting peripheral blood mono...

journal_title：Cellular immunology

authors： Tufano MA,Porta R,Farzati B,Di Pierro P,Rossano F,Catalanotti P,Baroni A,Metafora S

更新日期：1996-03-15 00:00:00

abstract：:Epstein-Barr virus (EBV) readily immortalizes human peripheral blood lymphocytes (PBL) in vitro. However, during the past several years, we found that PBL from two exceptional EBV-seropositive healthy adult individuals were refractory to immortalization by EBV. We report here a study aimed at learning about the immuno...

journal_title：Cellular immunology

authors： Gosselin J,Menezes J,Mercier G,Lamoureux G,Oth D

更新日期：1989-09-01 00:00:00