Interleukin-2 induces apoptosis in mouse thymocytes.

abstract：:CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic HIV-1 strains to enter the host cells. In this study, we aim to better understand the ligand-binding profiles of CCR5 and the chemokine-receptor usage on leukocyte cells. We fou...

journal_title：Cellular immunology

authors： Ruffing N,Sullivan N,Sharmeen L,Sodroski J,Wu L

更新日期：1998-11-01 00:00:00

abstract：:We systematically investigated the impact of the relative maturation levels of dendritic cells (DCs) on their cell surface phenotype, expression of cytokines and chemokines/chemokine receptors (by DNA array and RNase protection analyses), biological activities, and abilities to induce tumor immunity. Mature DCs expres...

journal_title：Cellular immunology

authors： Chen Z,Dehm S,Bonham K,Kamencic H,Juurlink B,Zhang X,Gordon JR,Xiang J

更新日期：2001-11-25 00:00:00

abstract：:In this study we investigated whether T cells expressing high or low levels of CD62L were differentially susceptible to the T cell chemokine lymphotactin. We found that lymphotactin induced preferential migration of antigen-specific (CD62L(lo)) T cells over the nonspecific (CD62L(hi)) T cells in vitro and in vivo. The...

journal_title：Cellular immunology

authors： Kurt RA,Bauck M,Harma S,McCulloch K,Baher A,Urba WJ

更新日期：2001-05-01 00:00:00

abstract：:Lung cancer cells harboring multiple mutations as a consequence of long-term damage by different etiologic factors are responsible for high immunogenicity. Immune checkpoint inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC). Unfortunately, the role of T-lymphocytes in early NSCLC...

journal_title：Cellular immunology

authors： Rutkowski J,Cyman M,Ślebioda T,Bemben K,Rutkowska A,Gruchała M,Kmieć Z,Pliszka A,Zaucha R

更新日期：2017-12-01 00:00:00

abstract：:Study of primary immune responses in leprosy has been limited, since disease becomes manifest long after infection or is not detectable. To study primary immune responses, we immunized in vitro human peripheral blood mononuclear cells from unexposed individuals using phenolic glycolipid 1 (PGL-1), an important water-i...

journal_title：Cellular immunology

authors： Schauf V,Holobaugh P,Miller P,Mittal K

更新日期：1991-10-01 00:00:00

abstract：:The mechanism of how superantigens function to activate cells has been linked to their ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule. Cells that lack the MHCII molecule also respond to superantigens, however, with much less efficiency. Therefore, the purpose of this stud...

journal_title：Cellular immunology

authors： Wright AD,Chapes SK

更新日期：1999-11-01 00:00:00

abstract：:Chemotactic migration of T lymphocytes and neutrophil granulocytes within a three-dimensional collagen matrix is distinct from spontaneous, matrix-induced migration concerning dynamic parameters and regulatory intracellular signaling. Both spontaneous T lymphocyte locomotion and stromal-cell-derived factor-1 (SDF-1)-i...

journal_title：Cellular immunology

authors： Entschladen F,Gunzer M,Scheuffele CM,Niggemann B,Zänker KS

更新日期：2000-02-01 00:00:00

abstract：:The effects of mAb therapy to CD4 or CD8 on induction of unresponsiveness to Heymann's nephritis by preimmunization with renal tubular antigen in IFA. Anti-CD4 mAbs (MRC Ox35) given for 2 weeks after RTA/IFA completely prevented the induction of resistance to HN, all rats developing proteinuria as well as high titers ...

journal_title：Cellular immunology

authors： Quiza CG,Leenaerts PL,Hall BM

更新日期：1991-04-01 00:00:00

abstract：:The ability of calcium ionophore and phorbol ester to stimulate entry into S phase was assessed during short-term cultures of murine B cells extensively depleted of T cells. Neither ionomycin alone nor PMA alone stimulated DNA synthesis. However, the combination of ionomycin plus PMA acted in synergy to induce initiat...

journal_title：Cellular immunology

authors： Rothstein TL,Baeker TR,Miller RA,Kolber DL

更新日期：1986-10-15 00:00:00

abstract：:PNK-E and G7 mAbs regulate porcine NK and ADCC activities by binding to distinct NK function-associated trigger molecules on porcine NK cells. Previous work demonstrates that PNK-E mAb binds to a 205-kDa tetrameric molecule composed of two 47-kDa peptides and two 50-kDa peptides and G7 mAb binds to a distinct 40-kDa h...

journal_title：Cellular immunology

authors： Wierda WG,Johnson BD,Dato ME,Kim YB

更新日期：1993-02-01 00:00:00

abstract：:Development of contact hypersensitivity in mice depends on the migration of Langerhans cells from the epidermis to regional lymph nodes. Since ICAM-1 and LFA-1 play important roles in leukocyte migration, we sought to determine whether in vivo administration of anti-ICAM-1 and anti-LFA-1 antibodies would inhibit conta...

journal_title：Cellular immunology

authors： Ma J,Wang JH,Guo YJ,Sy MS,Bigby M

更新日期：1994-10-15 00:00:00

abstract：:Phagocytes play a central role in immune defense. Their dysfunction predisposes to infections. This study determined the expression level of nine receptors involved in Aspergillus immune response as well as the values of phagocytosis and production of radical oxygen species after Aspergillus stimulation, in a healthy ...

journal_title：Cellular immunology

authors： Aldebert D,Hypolite M,Bal G,Dumestre-Pérard C,Bertini RL,Rolland C,Boutonnat J,Grillot R,Pelloux H,Brion JP

更新日期：2011-01-01 00:00:00

abstract：:This study examines cytotoxic mechanisms used by channel catfish peripheral blood-derived effector cells. Transmission electron microscopy (TEM), coupled with [(3)H]thymidine DNA fragmentation (JAM) and terminal deoxynucleotidyl nick-end labeling (TUNEL) assays, provided the first evidence that catfish peripheral bloo...

journal_title：Cellular immunology

authors： Hogan RJ,Taylor WR,Cuchens MA,Naftel JP,Clem LW,Miller NW,Chinchar VG

更新日期：1999-08-01 00:00:00

abstract：:Oxidants, heavy metals, and heat shock, collectively known as stress stimuli, induce the synthesis of a variety of proteins, termed stress proteins, and enhance glucose uptake. In this study, we have demonstrated that stress stimuli enhance protein tyrosine phosphorylation (PTyr-P), modulate protein tyrosine phosphata...

journal_title：Cellular immunology

authors： Lander HM,Levine DM,Novogrodsky A

更新日期：1992-11-01 00:00:00

abstract：:The pathogenic antibody response to acetylcholine receptor (AChR) in experimental autoimmune myasthenia gravis (EAMG) is T cell dependent. Therefore, it should be possible to design specific immunotherapeutic approaches to treat EAMG (and human MG) by interfering with AChR-specific helper T cells. Productive T cell ac...

journal_title：Cellular immunology

authors： McIntosh KR,Linsley PS,Drachman DB

更新日期：1995-11-01 00:00:00

abstract：:Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline ...

journal_title：Cellular immunology

authors： Leng SX,Margolick JB

更新日期：2020-02-01 00:00:00

abstract：:We showed previously that the expressions of various src family protein tyrosine kinases (PTKs) were induced independently during the monocytic differentiation of HL-60 cells. The role of PTKs was further assessed in the present study by investigating the effects of PTK inhibitors on the differentiation. It was demons...

journal_title：Cellular immunology

authors： Katagiri K,Katagiri T,Kajiyama K,Uehara Y,Yamamoto T,Yoshida T

更新日期：1992-04-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis in the skin and internal organs. The pathogenesis of SSc is not completely understood until now. Recently, many studies have focused on the role of E3 ubiquitin ligases in organ fibrosis. However, the possible regulatory mechanisms of E3 ubiqu...

journal_title：Cellular immunology

authors： Huang XL,Zhang L,Duan Y,Wang YJ,Zhao JH,Wang J

更新日期：2016-08-01 00:00:00

abstract：:This study was conducted to investigate the effects of sex hormones upon the nature of soluble immune response suppressor (SIRS) produced by concanavalin A-stimulated Lyt-2+ T cells. Conventional SIRS affected IgM PFC only. However, SIRS made with progesterone (20-400 ng/ml or Prog-SIRS) suppressed IgM PFC, one-way ML...

journal_title：Cellular immunology

authors： Kita E,Hamuro A,Oku D,Nishikawa F,Yasui K,Emoto M,Katsui N,Kashiba S

更新日期：1990-10-01 00:00:00

abstract：:American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

journal_title：Cellular immunology

authors： Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

更新日期：2012-10-01 00:00:00

abstract：:We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, ...

journal_title：Cellular immunology

authors： Tanaka S,Sakamoto H

更新日期：2011-01-01 00:00:00

abstract：:Aging induces a number of changes in the immune system, including the involution of the thymus which results in the loss of thymic hormone production and alteration in T cell function. One age-dependent change in immune response is the increasing risk of developing acute or chronic form of graft-versus-host disease (G...

journal_title：Cellular immunology

authors： Fast LD,Kouttab NM,Badamchian M,Goldstein AL

更新日期：1990-11-01 00:00:00

abstract：:Here, we established CD4(+)αβTh1 clones specific for rat vascular smooth muscle antigen (VSMAg) that induced vasculitis lesions in the lungs of MRL/Mp-Fas(+/+) mice following adoptive transfer. Six different T cell clones, MV1b1 (Vβ1), MV1b4 (Vβ4), MV1b8.3 (Vβ8.3), MV1b61 (Vβ6), MV1b62 (Vβ6), and MV1b63 (Vβ6), were is...

journal_title：Cellular immunology

authors： Fujita Y,Fujii T,Shimizu H,Sato T,Nakamura T,Iwao H,Nakajima A,Miki M,Sakai T,Kawanami T,Tanaka M,Masaki Y,Fukushima T,Okazaki T,Umehara H,Mimori T

更新日期：2016-05-01 00:00:00

abstract：:The nuclear receptor Small Heterodimer Partner (SHP) is a transcriptional target and inhibitor of Liver Receptor Homolog 1 (LRH-1), the transcriptional regulator of intestinal glucocorticoid (GC) synthesis. The role of SHP in the regulation of intestinal GC synthesis and its impact on T cell-mediated anti-viral immune...

journal_title：Cellular immunology

authors： Huang J,Jia R,Brunner T

更新日期：2018-12-01 00:00:00

abstract：:Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Troj...

journal_title：Cellular immunology

authors： Clark AJ,Petty HR

更新日期：2010-01-01 00:00:00

abstract：:The mode of action of T-cell-suppressor factor (TsF) induced by ultraviolet B (UVB) preirradiation in terms of interaction with several cytokines was studied. Suppression of murine contact photosensitivity (CPS) to 3,3',4',5-tetrachlorosalicylanilide (TCSA) by preirradiation of the sensitizing site to low doses of UVB...

journal_title：Cellular immunology

authors： Satoh T,Tokura Y,Satoh Y,Takigawa M

更新日期：1990-11-01 00:00:00

abstract：:Two interleukin-2 (IL-2)-dependent cytotoxic T-cell clones were obtained by limiting dilution from a lymphocyte culture stimulated in vitro with the autologous Epstein-Barr virus-transformed lymphoblastoid cell line (LCL) in the presence of fetal calf serum (FCS). Both clones uniformly had a T3+, T4+, Dr+ phenotype an...

journal_title：Cellular immunology

authors： Torsteinsdottir S,Masucci MG,Brautbar C,Lenoir G,Klein G,Klein E

更新日期：1986-04-01 00:00:00

abstract：:UM4D4 is a recently defined antigen that is expressed on approximately 25% of peripheral blood T cells, but on the majority of T cells in inflammatory synovial fluid. Anti-UM4D4 activates peripheral blood T cells in the presence of accessory cells and/or phorbol ester. UM4D4 has been assigned to a new antigen cluster ...

journal_title：Cellular immunology

authors： Fox DA,Davis W,Zeldes W,Kan L,Higgs J,Duby AD,Holoshitz J

更新日期：1990-07-01 00:00:00

abstract：:We have recently demonstrated that estrogen has differential immunomodulatory properties in mice because it stimulates antibody responses but inhibits T cell-mediated inflammation. In the present study we have examined the influence of estrogen on T cell-independent inflammatory responses. A local inflammation was ind...

journal_title：Cellular immunology

authors： Josefsson E,Tarkowski A,Carlsten H

更新日期：1992-06-01 00:00:00

abstract：:CD40--CD40L interactions between resting B cells and activated T cells are essential for germinal center formation. It has been shown that CD40L can induce both Fas expression and susceptibility to Fas-mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas-mediated killing. However, the intra...

journal_title：Cellular immunology

authors： Zhang X,Li L,Choe J,Krajewski S,Reed JC,Thompson C,Choi YS

更新日期：1996-10-10 00:00:00