当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Beta2-integrin, LFA-1, and TCR/CD3 synergistically induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in PHA-activated T cells.

Beta2-integrin, LFA-1, and TCR/CD3 synergistically induce tyrosine phosphorylation of focal adhesion kinase (pp125(FAK)) in PHA-activated T cells.

Abstract：

:Complete T cell activation requires not only a first signal via TCR/CD3 engagement but also a costimulatory signal through accessory receptors such as CD2, CD28, or integrins. Focal adhesion kinase, pp125(FAK) (FAK), was previously shown to be localized in focal adhesions in fibroblasts and to be involved in integrin-mediated cellular activation. Although signaling through beta1- or beta3-integrins induces tyrosine phosphorylation of FAK, there has been no evidence that activation of T cells through the beta2-integrin, LFA-1, involves FAK. We report here that crosslinking of LFA-1 induces tyrosine phosphorylation of FAK in PHA-activated T cells. Moreover, cocrosslinking with anti-LFA-1 mAb and suboptimal concentration of anti-CD3 mAb markedly increases tyrosine phosphorylation of FAK in an antibody-concentration-dependent and time-kinetics-dependent manner compared with stimulation through CD3 alone, which correlates well with enhanced proliferation of PHA-activated T cells. Furthermore, LFA-1beta costimulation with CD3 induces tyrosine phosphorylation of Syk associated with FAK. These results indicate, for the first time, that signals mediated by LFA-1 can regulate FAK, suggesting that LFA-1-mediated T cell costimulation may be involved in T cell activation at least partially through FAK.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Tabassam FH,Umehara H,Huang JY,Gouda S,Kono T,Okazaki T,van Seventer JM,Domae N

doi

10.1006/cimm.1999.1472

subject

Has Abstract

pub_date

1999-05-01 00:00:00

pages

179-84

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008874999914727

journal_volume

193

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Kinetics of interleukin-4 induction and interferon-gamma inhibition of IgE secretion by Epstein-Barr virus-infected human peripheral blood B cells.

    abstract：:Interleukin-4 (IL-4) acts directly on purified human peripheral blood B cells cultured in the presence of Epstein-Barr virus (EBV) to induce IgE secretion and to enhance the secretion of IgG and IgM. Interferon-gamma (IFN-gamma) inhibits IgE secretion in this system, without affecting the secretion of the other Ig iso...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90114-q

    authors： Thyphronitis G,Banchereau J,Heusser C,Tsokos GC,Levine AD,Finkelman FD

    更新日期：1991-04-01 00:00:00

  • The role of Toll-like receptor signalling in the pathogenesis of arthritis.

    abstract：:Recent evidence highlighted the role of Toll-like receptors (TLRs) as key recognition structures of the innate immune system. The activation of TLRs initiates the production of inflammatory cytokines, chemokines, tissue destructive enzymes, and type I interferons. In addition, TLR signalling plays an important role in...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2005.04.018

    authors： Brentano F,Kyburz D,Schorr O,Gay R,Gay S

    更新日期：2005-02-01 00:00:00

  • Phenotypic and functional changes of GM-CSF differentiated human macrophages following exposure to apoptotic neutrophils.

    abstract：:The engulfment of apoptotic cells by monocytes and unprimed macrophages results in M2 polarization. In the current study, we investigated whether apoptotic cells influence the phenotypic and functional characteristics of GM-CSF-differentiated human macrophages (GM-Mφ). Our results demonstrate that GM-Mφ preincubated w...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.06.002

    authors： Chernykh ER,Sakhno LV,Shevela EY,Tikhonova MA,Khonina NA,Ostanin AA

    更新日期：2018-09-01 00:00:00

  • AGR2-mediated lung adenocarcinoma metastasis novel mechanism network through repression with interferon coupling cytoskeleton to steroid metabolism-dependent humoral immune response.

    abstract：:7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease database...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2014.05.008

    authors： Huang J,Wang L,Jiang M,Chen Q,Jiang Z,Feng H

    更新日期：2014-07-01 00:00:00

  • Tolerogenic vaccines: Targeting the antigenic and cytokine niches of FOXP3+ regulatory T cells.

    abstract：:FOXP3+ regulatory T cells (Tregs) constitute a critical barrier that enforces tolerance to both the self-peptidome and the extended-self peptidome to ensure tissue-specific resistance to autoimmune, allergic, and other inflammatory disorders. Here, we review intuitive models regarding how T cell antigen receptor (TCR)...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2020.104173

    authors： Mannie MD,DeOca KB,Bastian AG,Moorman CD

    更新日期：2020-09-01 00:00:00

  • An evaluation of the maternal natural killer cell population during the course of murine pregnancy.

    abstract：:Earlier work from this laboratory revealed an increase in the level of null (Thy-1-, IgM-) lymphocytes in the maternal lymphoid organs during the first pregnancy in the mouse that was more pronounced during allogeneic pregnancy than during syngeneic pregnancy. In view of the suggestive evidence for the bone marrow ori...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90098-4

    authors： Chatterjee-Hasrouni S,Parhar R,Lala PK

    更新日期：1984-04-01 00:00:00

  • Autophagy efficacy and vitamin D status: Population effects.

    abstract：:Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are in...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2020.104082

    authors： Abhimanyu,Meyer V,Jones BR,Bornman L

    更新日期：2020-06-01 00:00:00

  • Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response.

    abstract：:The objective of this study was to evaluate the potential of transcutaneous immunization with tumor antigen to induce cell-mediated immunity. For this purpose, hydrophilic recombinant gp100 protein (HR-gp100) was topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. We demonstrate th...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.09.003

    authors： Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M

    更新日期：2010-01-01 00:00:00

  • Interleukin-3 and Flt3-ligand induce adhesion of Baf3/Flt3 precursor B-lymphoid cells to fibronectin via activation of VLA-4 and VLA-5.

    abstract：:Adhesion of hematopoietic cells to extracellular matrix components is important for blood cell development. However, little is known regarding the potential influence of IL-3 on this process for precursor B cells and Flt3-ligand has not yet been implicated in induction of adhesion of any blood cell types to extracellu...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1318

    authors： Shibayama H,Anzai N,Ritchie A,Zhang S,Mantel C,Broxmeyer HE

    更新日期：1998-07-10 00:00:00

  • The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions.

    abstract：:Inhibition of DPP IV has been shown to abrogate the stress-related increase in murine abortions and a concomitant increase in gamma-interferon. The aim of the present study was to investigate a potential impact of the DPP IV inhibitor Isoleucine Cyanopyrrolidide on the expression of surface antigens involved in T-cell...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/s0008-8749(03)00028-5

    authors： Rüter J,Hoffmann T,Heiser U,Demuth HU,Arck PC,Klapp BF,Hildebrandt M

    更新日期：2002-12-01 00:00:00

  • Sulfated modification can enhance the immune-enhancing activity of lycium barbarum polysaccharides.

    abstract：:In test in vitro, four sulfated lycium barbarum polysaccharides (sLBPSs) with different degrees of sulfation (DS), sLBPS0.7, sLBPS1.1, sLBPS1.5 and sLBPS1.9, were added into cultured chicken peripheral lymphocytes and the changes of lymphocytes proliferation were compared by MTT assay taking the non-modified LBPS as c...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.04.001

    authors： Wang J,Hu Y,Wang D,Liu J,Zhang J,Abula S,Zhao B,Ruan S

    更新日期：2010-01-01 00:00:00

  • Differential interleukin-2 and interferon-gamma production by human lymphocyte cultures exceptionally resistant to Epstein-Barr virus immortalization.

    abstract：:Epstein-Barr virus (EBV) readily immortalizes human peripheral blood lymphocytes (PBL) in vitro. However, during the past several years, we found that PBL from two exceptional EBV-seropositive healthy adult individuals were refractory to immortalization by EBV. We report here a study aimed at learning about the immuno...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90090-7

    authors： Gosselin J,Menezes J,Mercier G,Lamoureux G,Oth D

    更新日期：1989-09-01 00:00:00

  • Target-induced anergy of natural killer cytotoxic function is restricted to the NK-target conjugate subset.

    abstract：:This study examined the characteristics of functional anergy of natural killer cells (NK) following their interaction with target cells. Purified NK cells were cocultured with K562 for 15 min or 4 hr to allow for binding of targets to NK cells. The resulting NK-target conjugates were then dissociated by EDTA, and the ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(95)80013-9

    authors： Jewett A,Bonavida B

    更新日期：1995-01-01 00:00:00

  • Class I-like CD1A-C do not protect target cells from NK-mediated cytolysis.

    abstract：:Previous studies have validated the capacity of classical (HLA-A,B,C) and nonclassical (HLA-G) MHC class I antigens expressed by target cells to influence natural killer (NK) cell-mediated cytolysis. Generally, elevated expression of these HLA class I molecules is correlated with enhanced resistance to lysis by NK cel...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0020

    authors： Storkus WJ,Wei M,Cresswell P,Dawson JR

    更新日期：1996-01-10 00:00:00

  • Interleukin-10 production by B cells is regulated by cytokines, but independently of GATA-3 or FoxP3 expression.

    abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2019.103987

    authors： Bohacova P,Kossl J,Hajkova M,Hermankova B,Javorkova E,Zajicova A,Krulova M,Holan V

    更新日期：2020-01-01 00:00:00

  • Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways.

    abstract：:IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD)...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.04.008

    authors： Wu CA,Peluso JJ,Zhu L,Lingenheld EG,Walker ST,Puddington L

    更新日期：2010-01-01 00:00:00

  • The role of indoleamine 2,3-dioxygenase (IDO) in immune tolerance: focus on macrophage polarization of THP-1 cells.

    abstract：:Macrophages can be divided into two groups as M1 and M2 phenotype. Our results and other groups revealed that IFN-γ can up-regulate the IDO expression and differentiate THP-1 cells to M1 phenotype. Therefore we hypothesized that IDO may play potential roles in macrophage differentiation. Interesting, our results indic...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2014.02.005

    authors： Wang XF,Wang HS,Wang H,Zhang F,Wang KF,Guo Q,Zhang G,Cai SH,Du J

    更新日期：2014-05-01 00:00:00

  • Two distinct porcine natural killer lytic trigger molecules as PNK-E/G7 molecular complex.

    abstract：:PNK-E and G7 mAbs regulate porcine NK and ADCC activities by binding to distinct NK function-associated trigger molecules on porcine NK cells. Previous work demonstrates that PNK-E mAb binds to a 205-kDa tetrameric molecule composed of two 47-kDa peptides and two 50-kDa peptides and G7 mAb binds to a distinct 40-kDa h...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1026

    authors： Wierda WG,Johnson BD,Dato ME,Kim YB

    更新日期：1993-02-01 00:00:00

  • Mechanisms in opposite modulation of spleen cell and lymph node cell responses to mitogens following muramyl dipeptide treatment in vivo.

    abstract：:It has been reported that a muramyl dipeptide (MDP) treatment regimen (200 micrograms MDP per mouse, Days -4, -3, -2, and -1) that, given prophylactically, affords protection against several infectious agents also induces lymph node hyperplasia, lymph node cell (LNC) hyperresponsiveness to mitogens, and spleen cell hy...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90248-5

    authors： Brummer E,Stevens DA

    更新日期：1985-04-01 00:00:00

  • Antigenic phenotype of TdT-positive cells in human peripheral blood.

    abstract：:Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90223-0

    authors： Bradstock KF,Kerr A,Bollum FJ

    更新日期：1985-02-01 00:00:00

  • Tiazofurin induces a down-modulation of ICAM-1 expression on K562 target cells impairing NK adhesion and killing.

    abstract：:Tiazofurin treatment of K562 leukemia cells in vitro depletes the metabolites of the guanylate biosynthetic pathway, inducing erythroid differentiation, that, in turn, alters the phenotypic profile. As a consequence, K562 cells possibly modify their interaction with immune cells. Here we describe the binding and killi...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1995.1147

    authors： Zamai L,Zauli G,Bavelloni A,Marmiroli S,Cataldi A,Weber G,Vitale M

    更新日期：1995-08-01 00:00:00

  • Evaluation of interleukin-23 plasma levels in patients with polycythemia vera and essential thrombocythemia.

    abstract：:Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis share the same acquired genetic lesion, JAK2V617F. It is believed that cytokines participate in the activation of JAK2V617F. In this study, we analyzed the plasma levels of interleukin (IL)-23, IL-10 and IL-22 in patients with PV and ET. In the s...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2012.07.003

    authors： Gangemi S,Allegra A,Pace E,Alonci A,Ferraro M,Petrungaro A,Saitta S,Gerace D,Russo S,Penna G,Musolino C

    更新日期：2012-07-01 00:00:00

  • Complement deposition on immune complexes reduces the frequencies of metabolic, proteolytic, and superoxide oscillations of migrating neutrophils.

    abstract：:Neutrophils exhibit intrinsic sinusoidal metabolite concentration oscillations of 3 min in resting cells and an additional approximately 10- or 20-s oscillation in migrating/adhering cells. To better understand immune complex (IC)-mediated leukocyte activation, we have studied neutrophil metabolic oscillations in the ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1481

    authors： Amit A,Kindzelskii AL,Zanoni J,Jarvis JN,Petty HR

    更新日期：1999-05-25 00:00:00

  • Mechanism of augmentation of the antibody response in vitro by 2-mercaptoethanol in murine lymphocytes. II. A major role of the mixed disulfide between 2-mercaptoethanol and cysteine.

    abstract：:Five thiol compounds including 2-mercaptoethanol (2-ME) were examined for their augmenting effects on in vitro antibody response to sheep erythrocytes. Three compounds were effective with the following order of activity; 2-ME greater than dithiothreitol greater than cysteamine. Glutathione and thioglycollate failed to...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90060-6

    authors： Ohmori H,Yamamoto I

    更新日期：1983-07-01 00:00:00

  • Sequential analysis of experimental autoimmune thyroiditis induced by neonatal thymectomy in the Buffalo strain rat.

    abstract：:We have studied the evolution of thyroiditis induced by neonatal thymectomy in Buffalo strain rats, with particular emphasis on the thyroid lymphocytic infiltrate. The earliest change was increased endothelial Ia expression, and infiltration of the thyroid at 5 weeks by ED1- and ED2-positive macrophages and B and T ce...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90260-2

    authors： Cohen SB,Dijkstra CD,Weetman AP

    更新日期：1988-06-01 00:00:00

  • Effect of a local immune reaction on peripheral blood polymorphonuclear neutrophil microbicidal function: studies with fungal targets.

    abstract：:Peripheral blood polymorphonuclear neutrophils (PMN) from mice immunized with Blastomyces dermatitidis and then stimulated locally (intraperitoneally, ip) with B. dermatitidis antigen had enhanced killing of B. dermatitidis in vitro (54.4 +/- 19.49 of inoculum) compared to nonimmune mice (32.7 +/- 8.7%; P less than 0....

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90111-0

    authors： Morrison CJ,Brummer E,Stevens DA

    更新日期：1987-11-01 00:00:00

  • Characterization of a low molecular weight suppressor of lymphocyte proliferation from guinea pig L2C leukemia cells.

    abstract：:Conditioned medium (CM) from 24-hr culture of guinea pig L2C B lymphoblastic leukemia cells contained an inhibitor(s) of mitogen- and antigen-stimulated proliferation of syngeneic (strain 2 guinea pigs), allogeneic (Hartley guinea pigs), and xenogeneic (Balb/c mouse, NZW rabbit) lymphocytes. The proliferation of sever...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90087-6

    authors： Collins DP,Cook DJ,Ricardo MJ Jr

    更新日期：1987-04-01 00:00:00

  • Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats.

    abstract：:Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic r...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2014.04.004

    authors： Mojani MS,Sarmadi VH,Vellasamy S,Sandrasaigaran P,Rahmat A,Peng LS,Ramasamy R

    更新日期：2014-05-01 00:00:00

  • Intranasal delivery of cationic liposome-protamine complex mRNA vaccine elicits effective anti-tumor immunity.

    abstract：:Immunization with synthetic mRNA encoding tumor-associated antigens is an emerging vaccine strategy for the treatment of cancer. In order to prevent mRNA degradation, promote antigen-presenting cells antigen presentation, and induce an anti-tumor immune response, we investigated the nasal administration of mRNA vaccin...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2020.104143

    authors： Mai Y,Guo J,Zhao Y,Ma S,Hou Y,Yang J

    更新日期：2020-08-01 00:00:00

  • Cytokine regulation of bone marrow natural suppressor cell activity in the suppression of lymphocyte function.

    abstract：:Natural suppressor (NS) cells, which nonspecifically suppress immune responses, are present in the spleen following exposure to radiation, chronic graft-versus-host disease, or cancer and in normal bone marrow. A model system is described which allows the study of cytokines activating and inhibiting NS cells, cytokine...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90158-l

    authors： Moore SC,Theus SA,Barnett JB,Soderberg LS

    更新日期：1992-05-01 00:00:00