Abstract:
:This study aimed to describe the vascular and cellular histopathological changes that occurred in post-mastectomy seroma in an animal model. Unilateral mastectomies were conducted on 45 female albino rabbits. On day seven, the skin flap and the underlying tissues of the mastectomy regions were dissected and processed for histopathological examination using immunohistochemical staining of the T- and B-lymphocytes and macrophages (CD3, CD20, and CD68 respectively), and the vascular endothelia. The post-mastectomy regions in the seroma group showed a large number of inflammatory cells and newly formed blood vessels that lost the integrity of their endothelial cell linings, as revealed by the von Willebrand factor staining, as well the basement membrane, as revealed by the histochemical stain. The post-mastectomy seroma beds showed many CD3 and CD20+ve lymphocytes and CD68+ve macrophages. These macrophages were producing angiogenic factors, resulting in the persistent and continuous formation of new blood vessels. These new blood vessels were defective and represented an underlying cause of seroma formation.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Al-Gaithy ZK,Ayuob NNdoi
10.1016/j.cellimm.2011.10.021subject
Has Abstractpub_date
2012-01-01 00:00:00pages
130-6issue
2eissn
0008-8749issn
1090-2163pii
S0008-8749(11)00293-0journal_volume
272pub_type
杂志文章abstract::Viruses are related to the etiology of periodontitis. However, the role of viruses on Th17 cells infiltration in periodontitis lesions is unknown. Therefore, we examined the effects of TLR3 ligand on CCL20, which is related to Th17 cells migration, production in human gingival fibroblasts (HGFs). Polyinosinic-polycyti...
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pub_type: 杂志文章
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journal_title:Cellular immunology
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pub_type: 杂志文章
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journal_title:Cellular immunology
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pub_type: 杂志文章
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