Acquisition of functional MHC class II/peptide complexes by T cells during thymic development and CNS-directed pathogenesis.

abstract：:Experimental autoimmune encephalomyelitis was induced in a Lewis rat by sensitization with synthetic peptide GP68-86, representing the 68-86 sequence of guinea pig myelin basic protein (GPMBP). To delineate T cell determinants of GP68-86, lymph node cells from this rat were activated in culture with GP68-86 and were f...

journal_title：Cellular immunology

authors： Mannie MD,Paterson PY,U'Prichard DC,Thomas DW

更新日期：1989-09-01 00:00:00

abstract：:The objective of this study was to evaluate the potential of transcutaneous immunization with tumor antigen to induce cell-mediated immunity. For this purpose, hydrophilic recombinant gp100 protein (HR-gp100) was topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. We demonstrate th...

journal_title：Cellular immunology

authors： Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M

更新日期：2010-01-01 00:00:00

abstract：:Although it is known that IGF-1 increases T lymphocyte proliferation, the regulation of its receptor expression during the process has not been defined. Consequently the regulation of IGF-1R expression by IGF-1 and the activation events in human blood T lymphocytes and the Jurkat T cell line were now investigated. IGF...

journal_title：Cellular immunology

authors： Schillaci R,Brocardo MG,Galeano A,Roldán A

更新日期：1998-02-01 00:00:00

abstract：:Thirty-two cord blood samples taken after caesarean section or vaginal delivery and concurrent venous blood samples obtained from normal adult controls were evaluated using monoclonal antibodies. The percentage of circulating pan-T-cell+ lymphocytes was significantly lower in cord blood (46%) compared with adult contr...

journal_title：Cellular immunology

authors： Solinger AM

更新日期：1985-04-15 00:00:00

abstract：:Rotavirus infection of permissive cells is a multi-step process that requires interaction with several cell surface receptors. Integrins alpha2beta1, alpha4beta1, alphaXbeta2, and alphavbeta3 are involved in the attachment and entry into permissive cells for many rotavirus strains. However, possible roles of known par...

journal_title：Cellular immunology

authors： Halasz P,Fleming FE,Coulson BS

更新日期：2005-07-01 00:00:00

abstract：:This report describes a model for investigating the role of the thymus in regulating natural killer (NK) cell activity in vivo. Evidence is presented that the thymus can regulate NK cells, and that at least some NK cells can develop without thymic help. Marrow from thymectomized rats depleted of circulating T cells by...

journal_title：Cellular immunology

authors： Flexman JP,Holt PG,Mayrhofer G,Latham BI,Shellam GR

更新日期：1985-02-01 00:00:00

abstract：:Tumour necrosis factor (TNF) family ligands and their corresponding receptors play important roles in the immune system and are involved in immune regulation such as lymphoid development, cell proliferation, differentiation, activation and death. Antibodies against these ligands and receptors together with Fc-fusion p...

journal_title：Cellular immunology

authors： Ch'en PF,Xu XG,Liu XS,Liu Y,Song CJ,Screaton GR,Jin BQ,Xu XN

更新日期：2005-07-01 00:00:00

abstract：:The precise role of the granular enzyme A (granzyme A), a serine protease, in the lytic process of cytotoxic T lymphocytes (CTL) is not clear. We have recently constructed a CTL line transfected with the antisense gene of granzyme A (a-GrA). These a-GrA CTL had lower GrA activity as well as decreased lytic activities,...

journal_title：Cellular immunology

authors： Koo GC,Luk Y,Talento A,Wu J,Sirotina A,Fischer PA,Blake JT,Nguyen MP,Parsons W,Poe M

更新日期：1996-12-15 00:00:00

abstract：:The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...

journal_title：Cellular immunology

authors： Heidenreich S,Kubis T,Schmidt M,Fegeler W

更新日期：1994-09-01 00:00:00

abstract：:We evaluated the effects of the immunosuppressants cyclosporin A (CsA) and FK506 on the synthesis of nitric oxide (NO) induced by bacterial lipopolysaccharide (LPS) in J774 macrophages. CsA and FK506 each inhibited NO production by LPS in a concentration-dependent fashion, but the cytotoxicity was also evident at high...

journal_title：Cellular immunology

authors： Hattori Y,Nakanishi N

更新日期：1995-10-01 00:00:00

abstract：:During the gestational cycle the placental tissue does not express class II MHC antigens and whether this phenomenon is important to fetal survival has not yet been evoked. It has been reported that class II antigen expression precedes renal and cardiac graft rejection, which may also be the case in fetal abortion. In...

journal_title：Cellular immunology

authors： Athanassakis-Vassiliadis I,Galanopoulos VK,Grigoriou M,Papamatheakis J

更新日期：1990-07-01 00:00:00

abstract：:In this report, a subset of CD4(+) cells which kills autologous HLA class I positive and HLA class II negative non-small-cell lung cancer (NSCLC) cells is described. Killing was performed both by direct cytolytic mechanisms and by apoptosis. The peculiar characteristic of these effectors was their capability of lysing...

journal_title：Cellular immunology

authors： Semino C,Ferlazzo G,Ratto GB,Melioli G

更新日期：1999-09-15 00:00:00

abstract：:In view of the critical role played by bacillus Calmette-Guérin (BCG) in the development and functional activation of protective T cells against tuberculosis, it has become important to understand the mechanisms by which cytokines regulate BCG-mediated immune responses. There is evidence that cytokine-mediated suppres...

journal_title：Cellular immunology

authors： Méndez-Samperio P,Hernández-Garay M,García-Martínez E

更新日期：2000-06-15 00:00:00

abstract：:PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells, and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform. PD-1Deltaex2 and PD-1Deltaex3 are generated...

journal_title：Cellular immunology

authors： Nielsen C,Ohm-Laursen L,Barington T,Husby S,Lillevang ST

更新日期：2005-06-01 00:00:00

abstract：:We compared TLR responsiveness in PBMC from HIV-1-infected and uninfected individuals using the TLR agonists: TLR7 (3M-001), TLR8 (3M-002), and TLR7/8 (3M-011). Activation and maturation of plasmacytoid dendritic cells (pDC) were measured by evaluating CD86, CD40, and CD83 expression and myeloid dendritic cell (mDC) a...

journal_title：Cellular immunology

authors： Martinson JA,Roman-Gonzalez A,Tenorio AR,Montoya CJ,Gichinga CN,Rugeles MT,Tomai M,Krieg AM,Ghanekar S,Baum LL,Landay AL

更新日期：2007-11-01 00:00:00

abstract：:Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptibl...

journal_title：Cellular immunology

authors： Speziali E,Santiago AF,Fernandes RM,Vaz NM,Menezes JS,Faria AM

更新日期：2009-01-01 00:00:00

abstract：:Ligation of CD40 using anti-CD40 or soluble CD40-ligand activates numerous intracellular kinases which transduce signals to the nucleus. The nature whereby these signaling events are coupled to distal functional events in B cells is poorly understood. In this study, using anti-CD40 monoclonal antibodies which recogniz...

journal_title：Cellular immunology

authors： Sakata N,Hamelmann E,Siadak AW,Terada N,Gerwins P,Aruffo A,Johnson GL,Gelfand EW

更新日期：2000-05-01 00:00:00

abstract：:Al adjuvants are used in vaccines to increase the immune response. NTPDase and AChE play a pivotal role and act in the regulation of the immune system. The effect of Al exposure in vitro and in vivo on NTPDase and AChE activities in the lymphocytes of rats was determined. In vitro, ATP hydrolysis was decreased by 20.4...

journal_title：Cellular immunology

authors： Kaizer RR,Gutierres JM,Schmatz R,Spanevello RM,Morsch VM,Schetinger MR,Rocha JB

更新日期：2010-01-01 00:00:00

abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...

journal_title：Cellular immunology

authors： Gallily R,Sher T,Ben-Av P,Loewenstein J

更新日期：1989-06-01 00:00:00

abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...

journal_title：Cellular immunology

authors： Guo X,Zhang Y,Wang P,Li T,Fu W,Mo X,Shi T,Zhang Z,Chen Y,Ma D,Han W

更新日期：2012-07-01 00:00:00

abstract：:Older humans and experimental animals have been repeatedly found to have higher titers of autoantibodies than do younger individuals despite the impaired responses of older individuals to foreign antigens. The studies reported here were designed to examine the relationship between these two age-related changes in anti...

journal_title：Cellular immunology

authors： Bovbjerg DH,Kim YT,Schwab R,Schmitt K,DeBlasio T,Weksler ME

更新日期：1991-07-01 00:00:00

abstract：:The biological effects of IL-2 are mediated through high (complex of alpha and beta chain) or intermediate (beta chain) affinity IL-2 receptors. Previously, chimeric proteins composed of IL-2 and Pseudomonas exotoxin (IL-2-PE) were shown to be specifically cytotoxic to cells bearing IL-2 receptors. It has also been sh...

journal_title：Cellular immunology

authors： Puri RK,FitzGerald D,Leland P,Kozak RW,Pastan I

更新日期：1992-09-01 00:00:00

abstract：:It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...

journal_title：Cellular immunology

authors： Takeuchi T,Schlossman SF,Morimoto C

更新日期：1987-06-01 00:00:00

abstract：:Macrophages can be divided into two groups as M1 and M2 phenotype. Our results and other groups revealed that IFN-γ can up-regulate the IDO expression and differentiate THP-1 cells to M1 phenotype. Therefore we hypothesized that IDO may play potential roles in macrophage differentiation. Interesting, our results indic...

journal_title：Cellular immunology

authors： Wang XF,Wang HS,Wang H,Zhang F,Wang KF,Guo Q,Zhang G,Cai SH,Du J

更新日期：2014-05-01 00:00:00

abstract：:The nonspecific B-cell response induced by infecting mice with two nonlethal malaria parasites, Plasmodium chabaudi adami and Plasmodium yoelii, was analyzed in an isotype-specific reverse plaque assay. Our results showed different isotypic patterns in the two infections, although cells secreting immunoglobulin of all...

journal_title：Cellular immunology

authors： Langhorne J,Kim KJ,Asofsky R

更新日期：1985-01-01 00:00:00

abstract：:The objective of this investigation was to explore possible molecular changes for role of a high-fat diet (HFD)-induced oxidative stress in splenic lymphocytes, and whether a dietary lipoic acid (LA) supplement could attenuate these changes. Male C57BL/6 mice were fed one of three diets 10 weeks and outcome measures c...

journal_title：Cellular immunology

authors： Cui J,Xiao Y,Shi Y,Le G,Miao X

更新日期：2010-01-01 00:00:00

abstract：:Homozygosity for either the lpr (lymphoproliferation) or the gld (generalized lymphoproliferative disease) mutation in mice causes the development of strikingly similar hyperglobulinemia and lymphoproliferative syndromes. Nevertheless, previous studies of various C57BL/6 chimeras obtained by reconstitution of irradiat...

journal_title：Cellular immunology

authors： Velin D,Goettelfinger P,Froidevaux S,Loor F

更新日期：1993-05-01 00:00:00

abstract：:The role of protein synthesis during the activation of macrophages (M phi) by lymphokines (LK) was studied. Peritoneal murine macrophages elicited by proteose-peptone (pM phi) were activated with LK (supernatants from normal mouse spleen cells pulsed with concanavalin A) and tested for cytotoxicity in an 18 hr assay a...

journal_title：Cellular immunology

authors： Blasi E,Varesio L

更新日期：1984-04-15 00:00:00

abstract：:Inflammatory leukocytes of DA-to-WF rat renal allografts displayed significant cytolytic activity to natural killer (NK) target cells on Day 2 after transplantation. The NK activity, which was associated with large granular lymphocytes in discontinuous Percoll gradients, peaked on Day 4 and disappeared rapidly thereaf...

journal_title：Cellular immunology

authors： Nemlander A,Soots A,Häyry P

更新日期：1984-12-01 00:00:00

abstract：:Although it is well known that the CD3/T-cell receptor (TCR) complex modulates from the surface of T cells upon exposure to monoclonal antibodies (mAb) directed against it, the fate of bound mAb has not been yet elucidated. We therefore perform direct binding experiments of 125I-labeled mAb against CD3 or TCR to inves...

journal_title：Cellular immunology

authors： Schaffar L,Dallanegra A,Breittmayer JP,Carrel S,Fehlmann M

更新日期：1988-10-01 00:00:00