Abstract：
:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytolytic activity which, due to its neutralization by a specific antiserum against murine cloned recombinant tumor necrosis factor (rTNF), was identified as TNF-mediated. Both thioglycollate-elicited peritoneal macrophages and the normal macrophages cloned from our JBM phi 1.1 bone-marrow-derived cell line effectively produced TNF at levels similar to, or higher than, those obtained in the presence of high concentrations of lipopolysaccharide (LPS). Four other mycoplasma species demonstrated a varied capacity to induce TNF production by macrophages. Elevated TNF levels were also observed during macrophage-mediated cytolysis of murine A9 fibrosarcoma cells in the presence of either M. orale or LPS. Addition of the specific antiserum against rTNF at a concentration which neutralized all TNF activity in the co-cultures partially inhibited concomitant A9 cell killing. We can, therefore, conclude that M. orale induces TNF production which is, at least partially, responsible for subsequent tumor cell killing.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Gallily R,Sher T,Ben-Av P,Loewenstein Jdoi
10.1016/0008-8749(89)90012-9subject
Has Abstractpub_date
1989-06-01 00:00:00pages
146-53issue
1eissn
0008-8749issn
1090-2163pii
0008-8749(89)90012-9journal_volume
121pub_type
杂志文章abstract：:7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease database...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2014.05.008
更新日期：2014-07-01 00:00:00
abstract：:Spleen cells from neonatal mice belonging to strains with the I-J-b or I-J-k genotype, were treated with anti-I-Jb or anti-I-Jk antibody and complement. This reduces their suppressor cell activity as demonstrated by a decrease in the ability to suppress the mixed-lymphocyte reactivity of adult spleen cells. Injection ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90115-6
更新日期：1983-09-01 00:00:00
abstract：:The morbidity and mortality of infectious diseases are significantly increased in aged humans. Hence, vaccination has been suggested as a means to reduce or prevent the impact of infections on old individuals. However, it has remained unresolved whether or not standard vaccine adjuvants such as aluminum hydroxide (Alu...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(02)00005-9
更新日期：2002-01-01 00:00:00
abstract：:We previously demonstrated that injection of a high dose (4 X 10(9] of sheep erythrocytes (SRBC) into C57BL/6 mice results in the generation of splenic B cells (plastic nonadherent, Thy-1- and Ig+) which, when transferred to normal syngeneic recipients, subsequently induce antigen-specific suppressor T cells to suppre...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90242-9
更新日期：1984-01-01 00:00:00
abstract：:Thymic (T) or bursal (B) lymphocytes from chicks sensitized to Mycobacterium tuberculosis produce an avian lymphocyte inhibitory factor (LyIF). The physiochemical properties of both T and B LyIF were established by ultrafiltration which yielded four fractions with molecular weight ranges of greater than 100,000; 50,00...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90080-1
更新日期：1983-07-15 00:00:00
abstract：:NK activity is regulated by arachidonic acid metabolites. More precisely PGE2 and LTB4 decreases and increases respectively non-MHC-restricted cytotoxicity in humans. We have observed similar data in mice since NK activity was inhibited by PGE2 (10(-6) to 10(-8) M) and enhanced by LTB4 (10(-8) to 10(-12) M). On the ot...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90117-8
更新日期：1992-01-01 00:00:00
abstract：:The proliferative response of peripheral blood mononuclear cells (PBMC) in synthetic serum-free media depends on the presence of sufficient amounts of transferrin (Tf). In the present communication we show that the reduction of Tf concentration in culture media results in a decreased proliferation, whereas lymphokine ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90038-d
更新日期：1991-02-01 00:00:00
abstract：:Transforming growth factor beta1 (TGFbeta1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2005.02.004
更新日期：2004-11-01 00:00:00
abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(02)00513-0
更新日期：2002-05-01 00:00:00
abstract：:CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic HIV-1 strains to enter the host cells. In this study, we aim to better understand the ligand-binding profiles of CCR5 and the chemokine-receptor usage on leukocyte cells. We fou...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1998.1379
更新日期：1998-11-01 00:00:00
abstract：:Activated macrophages are known to release a variety of immunoregulatory substances including the low-molecular-weight substances hydrogen peroxide and lactate. We report here that lactate but not hydrogen peroxide is capable of supporting a substantial production of T-cell growth factor (TCGF) in cultures of accessor...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90224-3
更新日期：1987-09-01 00:00:00
abstract：:Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0086
更新日期：1996-04-10 00:00:00
abstract：:The effects of IL-10 on in vitro antigen-driven murine antibody responses and helper cell IL-4 and IFN-gamma secretory capacity were investigated. Low antigen concentrations stimulated high responses in all antibody isotypes examined; IgD was not assayed. Under these conditions, exogenous IL-10 minimally potentiated s...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0011
更新日期：1996-01-10 00:00:00
abstract：:Mice from strains showing either phenotypical expression of Bcg gene (C57BL/6, BALB/c, DBA/1, and (C57BL/6 X DBA/2)/F1, CBA, A/J, DBA/2) were infected intravenously with 10(7) Mycobacterium lepraemurium (MLM). The number of acid-fast bacilli (AFB) within the spleens, the ability of spleen cells to produce in vitro int...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90026-7
更新日期：1985-03-01 00:00:00
abstract：:Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable sup...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(95)80039-l
更新日期：1995-02-01 00:00:00
abstract：:The effect of low-dose irradiation on the immune system was investigated in mice. When a 0.2 Gy dose of X-ray irradiation was administered every other day for a total of four times, the number of lymphocytes yielded by the liver, spleen and thymus decreased at the initial stage (around day 10). At this stage, NK cells...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2007.02.009
更新日期：2006-11-01 00:00:00
abstract：:The Interferon-inducible gene IFI16, a member of the HIN200 family, is activated by oxidative stress and cell density, in addition to Interferons, and it is implicated in the regulation of endothelial cell proliferation and vessel formation in vitro. We have previously shown that IFI16 is required for proinflammatory ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.02.007
更新日期：2009-01-01 00:00:00
abstract：:Several lines of evidence suggest that nitric oxide (NO), generated through nitric oxide synthase (NOS) by cleavage of terminal guanidino nitrogen from L-arginine, mediates tumor cell killing by mononuclear phagocytes. Natural killer (NK) cells are cytotoxic effector cells that lyse a variety of tumor and virus-infect...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1215
更新日期：1994-08-01 00:00:00
abstract：:The in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on the production and utilization of interleukin-2 (IL-2) by normal human peripheral blood mononuclear cells (PBMC) was evaluated by measuring IL-2 concentrations in supernatants from PHA-stimulated PBMC cultures. Drugs were ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.1128
更新日期：1995-07-01 00:00:00
abstract：:In vivo adoptive transfer of T-cell-mediated immunity to the facultative intracellular bacterium Listeria monocytogenes is restricted, not only by the H-2 haplotype of the mice, but also by incompatibilities at non-H-2 loci. Thus, transfer between H-2 identical strains of mice with different background genes was repro...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90373-8
更新日期：1983-03-01 00:00:00
abstract：:We have previously shown that whole cell preparations of Candida albicans are capable of inducing immunosuppressive B-cell activity both in vivo and in vitro. In an effort to characterize the components of the yeast which manifest this immunomodulatory activity, we have successfully generated a soluble extract with di...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90149-4
更新日期：1989-08-01 00:00:00
abstract：:In this study a panel of monoclonal antibodies was used to investigate the kinetics of the appearance of activation-linked surface determinants as well as cytoplasmic and nuclear determinants in human T cells following lectin stimulation. Well known activation markers, such as Ia/DR, transferrin receptor, IL-2 recepto...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(85)90197-2
更新日期：1985-02-01 00:00:00
abstract：BACKGROUND:Piper nigrum L. (Piperaceae) is commonly used as a spice and traditional medicine in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the protective role of P. nigrum on epithelial function of uppe...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2019.104035
更新日期：2020-05-01 00:00:00
abstract：:Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors th...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2018.01.017
更新日期：2018-08-01 00:00:00
abstract：:Recent evidence highlighted the role of Toll-like receptors (TLRs) as key recognition structures of the innate immune system. The activation of TLRs initiates the production of inflammatory cytokines, chemokines, tissue destructive enzymes, and type I interferons. In addition, TLR signalling plays an important role in...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2005.04.018
更新日期：2005-02-01 00:00:00
abstract：:The inflammatory mechanisms that lead to the clinical symptoms that are grouped under the term inflammatory bowel disease have not been fully characterized. Although a specific mechanism has not been identified, inflammatory bowel disease is believed to be related to an inability by the immune system to shut active in...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2017.11.004
更新日期：2019-09-01 00:00:00
abstract：:Immunization with synthetic mRNA encoding tumor-associated antigens is an emerging vaccine strategy for the treatment of cancer. In order to prevent mRNA degradation, promote antigen-presenting cells antigen presentation, and induce an anti-tumor immune response, we investigated the nasal administration of mRNA vaccin...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2020.104143
更新日期：2020-08-01 00:00:00
abstract：:Class I antigens are necessary for the recognition of tumor cells by cytotoxic T lymphocytes (CTL). The line 1 lung carcinoma is a spontaneous murine tumor deficient in class I antigen expression. Consistent with this, line 1 cells are highly metastatic in vivo. We investigated whether increasing class I antigen expre...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90134-d
更新日期：1990-05-01 00:00:00
abstract：:Cells from the spleen, lymph nodes, and peritoneum of DBA/2 mice bearing a subcutaneous tumor mediate nonspecific suppression of an in vitro antibody response to sheep red blood cells (SRBC) when cocultured with a normal T-cell subset(s). The spleen cells from the tumor-bearing mouse required for the suppression bear ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90047-3
更新日期：1983-07-01 00:00:00
abstract：:Imidazoquinolone compounds, such as resiquimod are Toll-like receptor (TLR) 7/8 ligands representing novel immune response modifiers undergoing clinical testing. Resiquimod has been reported to modulate conventional human monocyte-derived DC (moDC) differentiation, but the role of TLR7 and TLR8 is unclear. We directly...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.08.008
更新日期：2011-01-01 00:00:00
