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Effect of LTB4 on the inhibition of natural cytotoxic activity by PGE2.

Abstract：

:NK activity is regulated by arachidonic acid metabolites. More precisely PGE2 and LTB4 decreases and increases respectively non-MHC-restricted cytotoxicity in humans. We have observed similar data in mice since NK activity was inhibited by PGE2 (10(-6) to 10(-8) M) and enhanced by LTB4 (10(-8) to 10(-12) M). On the other hand when PGE2 and LTB4 were combined during the same assay the lysis percentage was smaller than the one which was induced by PGE2 alone. Because PGE2 increases intracellular cyclic AMP and that LTB4 augments cyclic GMP we used a cAMP inducer (forskolin) and a cGMP analogue (8 Br-cGMP) instead of eicosanoids and we observed similar data (i.e., a decrease of natural killing) as when PGE2 was combined with LTB4. When splenocytes are cultured for 1-4 days alone, cytotoxic activity decreases unless they are cultured in the presence of indomethacin. Cytotoxic activity of spleen cells cultured in the presence of PGE2 or LTB4 is respectively decreased or increased. However, splenocytes that were cultured alone for at least 24 hr were no longer sensitive to inhibition by PGE2 but were still PGE2-sensitive when cultured in the presence of LTB4.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Vaillier D,Daculsi R,Gualde N,Bezian JH

doi

10.1016/0008-8749(92)90117-8

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

248-58

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(92)90117-8

journal_volume

139

pub_type

杂志文章

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