当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression.

IL-4 acts synergistically on the IL-2 response of an autoreactive T-cell clone; synergism correlates with increased intracellular IL-2, but not with a modified IL-2 receptor expression.

Abstract：

:TE44, an H-2b-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in a 5- to 10-fold enhancement of the specific biological activity of IL-2 on antigen-activated TE44-cells. This synergism was exerted nonreciprocally and required the presence of both lymphokines. IL-4 did not affect the number, nor the affinity, nor the rate of internalization of the high-affinity receptors for IL-2. However, increased levels of intracellular IL-2 were observed, suggesting an effect of IL-4 on the turnover of IL-2. This might allow a prolonged activity of IL-2 or IL-2-associated molecules inside the cell. Furthermore, the lack of autocrine growth factor production by antigen-stimulated TE44 is discussed in terms of its relationship to the autoimmune specificity of these T-cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Vandenabeele P,Grooten J,Fiers W

doi

10.1016/0008-8749(90)90163-l

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

79-91

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(90)90163-L

journal_volume

130

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Human anti-pneumococcal polysaccharide antibodies are secreted by the CD5- B cell lineage.

    abstract：:To determine whether human antibody responses to T cell-independent pneumococcal polysaccharide antigens are derived from CD5+ or CD5- B cells, we utilized an ELISPOT assay to detect individual anti-polysaccharide antibody-secreting cells. Human anti-type IV pneumococcal polysaccharide antibody-secreting cells were fo...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90006-b

    authors： Barrett DJ,Sleasman JW,Schatz DA,Steinitz M

    更新日期：1992-08-01 00:00:00

  • "Cross-wiring" of the immune response in old mice: increased autoantibody response despite reduced antibody response to nominal antigen.

    abstract：:Older humans and experimental animals have been repeatedly found to have higher titers of autoantibodies than do younger individuals despite the impaired responses of older individuals to foreign antigens. The studies reported here were designed to examine the relationship between these two age-related changes in anti...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90294-l

    authors： Bovbjerg DH,Kim YT,Schwab R,Schmitt K,DeBlasio T,Weksler ME

    更新日期：1991-07-01 00:00:00

  • Intracellular signaling events associated with the induction of DNA synthesis in human B lymphocytes. I. Stimulation of PKC-dependent and -independent pathways by LMW-BCGF.

    abstract：:The low molecular weight B cell growth factor (LMW-BCGF) induces the G1 --> S transition in human B lymphocytes activated by a first signal, Staphylococcus aureus Cowan (SAC) or anti-mu antibody. It also stimulates proliferation of normal long-term B cell lines and some B cell tumors. We have previously reported that ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1011

    authors： Kolb JP,Tran PL,Abadie A,Amirand C,Dugas B,Dugas B

    更新日期：1993-01-01 00:00:00

  • Requirement for accessory cells in suppression of MOPC-315 IgA secretion by staphylococcal enterotoxin B-induced T-suppressor cells.

    abstract：:Staphylococcal enterotoxin B (SEB) is a potent polyclonal activator of both human and murine T cells. We previously reported data which show that SEB-induced T cells suppress antibody secretion by various mouse plasmacytoma cell lines. This suppression of antibody secretion was found to be both idiotype and isotype no...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90227-i

    authors： Newcomb JR,Lin YS,Rogers TJ

    更新日期：1990-09-01 00:00:00

  • Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation.

    abstract：:The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2014.02.007

    authors： Kato T,Nishida T,Ito Y,Murase M,Murata M,Naoe T

    更新日期：2014-03-01 00:00:00

  • Distribution of immunoglobulin isotypes in the nonspecific B-cell response induced by infection with Plasmodium chabaudi adami and Plasmodium yoelii.

    abstract：:The nonspecific B-cell response induced by infecting mice with two nonlethal malaria parasites, Plasmodium chabaudi adami and Plasmodium yoelii, was analyzed in an isotype-specific reverse plaque assay. Our results showed different isotypic patterns in the two infections, although cells secreting immunoglobulin of all...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90187-x

    authors： Langhorne J,Kim KJ,Asofsky R

    更新日期：1985-01-01 00:00:00

  • Effect of LTB4 on the inhibition of natural cytotoxic activity by PGE2.

    abstract：:NK activity is regulated by arachidonic acid metabolites. More precisely PGE2 and LTB4 decreases and increases respectively non-MHC-restricted cytotoxicity in humans. We have observed similar data in mice since NK activity was inhibited by PGE2 (10(-6) to 10(-8) M) and enhanced by LTB4 (10(-8) to 10(-12) M). On the ot...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90117-8

    authors： Vaillier D,Daculsi R,Gualde N,Bezian JH

    更新日期：1992-01-01 00:00:00

  • Clonal anergy is a potent mechanism of oral tolerance in the suppression of acute antigen-induced arthritis in rats by oral administration of the inducing antigen.

    abstract：:The effects of oral administration of ovalbumin (OVA) on acute OVA-induced arthritis (OIA) in rats, which is mediated by Arthus reaction to the antigen in the joint space, were investigated. The oral administration of OVA before immunization with OVA significantly suppressed the development of acute OIA in a dose-depe...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.1049

    authors： Inada S,Yoshino S,Haque MA,Ogata Y,Kohashi O

    更新日期：1997-01-10 00:00:00

  • A monoclonal antibody to human B lymphoblastoid cells activates human and murine T lymphocytes.

    abstract：:A B lymphoblastoid cell line can provide a comitogenic, accessory signal for mitogen-treated T cells. In a study evaluating the antigenic determinant of such cells that mediate this effect, a monoclonal antibody (I57) was raised against the Daudi cell line. This antibody was found to interact with a 30-kDa protein on ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90354-7

    authors： Hardy B,Dotan D,Novogrodsky A

    更新日期：1989-01-01 00:00:00

  • The role of suppressor factors in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes. II. Activity of suppressor cell culture sonicates.

    abstract：:The purpose of this study was to determine whether multiple types of suppressor factors play a role in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes (UV Ts). The UV Ts were induced by applying contact allergens to the ventral, unirradiated skin of mice exposed 5 days earl...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90007-5

    authors： Yee GK,Ullrich SE,Kripke ML

    更新日期：1989-06-01 00:00:00

  • Characterization of cell-surface receptors for monoclonal-nonspecific suppressor factor (MNSF).

    abstract：:Monoclonal-nonspecific suppressor factor (MNSF) is a lymphokine derived from murine T cell hybridoma. The target tissues are both LPS-stimulated B cells and Con A-stimulated T cells. Since the action of MNSF may be mediated by its binding to specific cell surface receptors, we characterized the mode of this binding. T...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90271-r

    authors： Nakamura M,Ogawa H,Tsunematsu T

    更新日期：1990-10-15 00:00:00

  • Increased ornithine decarboxylase activity and polyamine biosynthesis are required for optimal cytolytic T lymphocyte induction.

    abstract：:The objective of the present investigation was to evaluate the requirement for increased ornithine decarboxylase (ODC) activity and polyamine biosynthesis in the induction of cytolytic T lymphocytes (CTL). In this regard, we have utilized alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ODC. DFMO tre...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90060-8

    authors： Bowlin TL,McKown BJ,Sunkara PS

    更新日期：1987-03-01 00:00:00

  • A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity.

    abstract：:An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.08.011

    authors： Gao Q,Li F,Wang S,Shen Z,Cheng S,Ping Y,Qin G,Chen X,Yang L,Cao L,Liu S,Zhang B,Wang L,Sun Y,Zhang Y

    更新日期：2019-09-01 00:00:00

  • Endotoxin induced TNF and IL-10 mRNA production is higher in male than female donors: correlation with elevated expression of TLR4.

    abstract：:Modification of cytokine production by gender hormones has been postulated to affect disease susceptibility and outcome. Here we investigate the effect of gender and the menstrual cycle on production of cytokines. Mononuclear cells were isolated every week for 10 consecutive weeks from healthy pre-menopausal women and...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.04.013

    authors： Temple SE,Pham K,Glendenning P,Phillips M,Waterer GW

    更新日期：2008-02-01 00:00:00

  • IFN-gamma IL-2, and IL-4 mRNA expression in the skin and draining lymph nodes of BALB/c mice repeatedly infested with nymphal Ixodes ricinus ticks.

    abstract：:The skin and draining lymph nodes of BALB/c mice were examined for IFN-gamma, IL-2, and IL-4 mRNA expression by in situ hybridization in three successive infestations with nymphal Ixodes ricinus ticks. IFN-gamma and IL-2 mRNA positive cells were readily detected in lymph node sections during primary antigenic stimulat...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1170

    authors： Mbow ML,Rutti B,Brossard M

    更新日期：1994-06-01 00:00:00

  • Internalization of iscom-borne antigens and presentation under MHC class I or class II restriction.

    abstract：:Exogenous nonreplicating antigens (Ag) incorporated into immunostimulating complexes (iscoms) induce CTL responses under MHC class I restriction. A requirement for inducing CTL responses is that the Ag is delivered to the cytosol of antigen-presenting cells (APC), a route restricted to endogenously produced Ag. To inv...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1278

    authors： Villacres MC,Behboudi S,Nikkila T,Lovgren-Bengtsson K,Morein B

    更新日期：1998-04-10 00:00:00

  • Effects of anti-CD4 antibody: enhancement of lymph node PPD-memory T cell response.

    abstract：:In vitro incubations of CD4+ T cells with anti-CD4 monoclonal antibody (Mab) demonstrated saturation binding and inhibited both PPD-stimulated proliferation and delayed-type hypersensitivity (DTH) after passive transfer of these cells into naive rats. In comparison, in vivo administration of anti-CD4 Mab into rats, 2 ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1995.1104

    authors： Morrison WJ,Kennedy NJ,Offner H,Vandenbark AA

    更新日期：1995-06-01 00:00:00

  • Partial restoration of Con A-induced proliferation, IL-2 receptor expression, and IL-2 synthesis in aged murine lymphocytes by phorbol myristate acetate and ionomycin.

    abstract：:The activation by concanavalin A (Con A) of murine lymphocytes derived from aged animals is impaired, as demonstrated by lower IL-2 synthesis, display of fewer IL-2 receptors, and less [3H]thymidine incorporation relative to similarly treated cells from young animals. The ability of the phorbol ester, phorbol 12-myris...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90250-x

    authors： Thoman ML,Weigle WO

    更新日期：1988-06-01 00:00:00

  • Sensitization in vitro of human peripheral blood mononuclear cells to phenolic glycolipid 1 of Mycobacterium leprae in liposomes.

    abstract：:Study of primary immune responses in leprosy has been limited, since disease becomes manifest long after infection or is not detectable. To study primary immune responses, we immunized in vitro human peripheral blood mononuclear cells from unexposed individuals using phenolic glycolipid 1 (PGL-1), an important water-i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90058-j

    authors： Schauf V,Holobaugh P,Miller P,Mittal K

    更新日期：1991-10-01 00:00:00

  • Macrophage defect and inflammatory cell recruitment dysfunction in Salmonella susceptible C3H/HeJ mice.

    abstract：:C3H/HeJ mice are homozygous for the Lpsd allele and, as a consequence, are hyporesponsive to all of the biological effects of bacterial lipopolysaccharide (LPS) that have been studied. These mice die in the early phase of infection when inoculated with virulent Salmonella. This susceptibility is also regulated by the ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90326-6

    authors： Weinstein DL,Lissner CR,Swanson RN,O'Brien AD

    更新日期：1986-10-01 00:00:00

  • Bacteria-derived human leukocyte interferons alter in vitro humoral and cellular immune responses.

    abstract：:Cultures of gradient-purified human peripheral blood mononuclear cells (PBMC) have been employed to examine the effects of three bacteria-derived human leukocyte interferon subtypes on certain aspects of in vitro immune responses. The addition of highly purified IFN-alpha 1, -alpha 2, -alpha 2/alpha 1 to PMBC cultures...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90161-2

    authors： Shalaby MR,Weck PK

    更新日期：1983-12-01 00:00:00

  • Protective efficacy of a plasmid DNA vaccine against transgene-specific tumors by Th1 cellular immune responses after intradermal injection.

    abstract：:With DNA vaccines, it is important to monitor the movement of transfectants and to overcome immune deviations. We used a pCMV-LacZ plasmid (expressing β-galactosidase) and a pcDNA-hNIS plasmid (expressing the human sodium/iodide symporter [hNIS] gene) as non-secreted visual-imaging markers. Transfectants carrying the ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.04.003

    authors： Son HY,Apostolopoulos V,Chung JK,Kim CW,Park JU

    更新日期：2018-07-01 00:00:00

  • Production of biologically active recombinant human soluble CD23 and its effect on PBMCs isolated from hyper-IgE blood.

    abstract：:A recombinant form of human soluble CD23 (sCD23), the low affinity receptor for IgE (FcepsilonRII), was produced by PCR cloning the lectin-binding domain sequence into a bacterial expression vector. After renaturation and purification, the sCD23 bound IgE and divalent metal ions, indicating its activity. The recombina...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2005.06.006

    authors： Daniels BB,Askew SL,van de Venter M,Oosthuizen V

    更新日期：2005-04-01 00:00:00

  • Human T-lymphocyte chemotactic activity: nature and production in response to antigen.

    abstract：:Previous studies have shown that supernatants from concanavalin A-stimulated human peripheral blood mononuclear cells and isolated Leu-2 suppressor/cytotoxic T cells are chemotactic for Leu-3 helper/inducer T cells. The current study shows that lymphocyte chemotactic factor (LCF) is also produced following antigen (te...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90375-8

    authors： Potter JW,Van Epps DE

    更新日期：1986-01-01 00:00:00

  • Anti-CD3-induced anergy in cloned human Th0, Th1, and Th2 cells.

    abstract：:In the mouse, activation of T cells by T cell receptor (TCR) crosslinking with anti-CD3 antibodies in the absence of a costimulatory signal induces Th1 but not Th2 cell anergy. Furthermore, anti-CD3 induces anergy of Th1- but not Th2-type lymphokine secretion in Th0 cells. This study was designed to determine whether ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1995.1199

    authors： Nguyen DD,Beck L,Spiegelberg HL

    更新日期：1995-10-01 00:00:00

  • Ontogeny and expression of non-MHC-restricted T cell antigen-binding molecules by thymocytes and peripheral T cell subsets.

    abstract：:The ontogeny of T cells which express major histocompatibility complex (MHC)-unrestricted T cell antigen-binding molecules (TABM) on the cell membrane was investigated. We used a rabbit anti-mouse TABM antiserum to investigate the expression of TABM by subsets of adult thymocytes, peripheral T cells, and thymocytes du...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90171-m

    authors： Rellahan BL,Cone RE

    更新日期：1990-10-01 00:00:00

  • A cell permeant peptide containing the cytoplasmic tail sequence of Fc receptor type IIA reduces calcium signaling and phagolysosome formation in neutrophils.

    abstract：:Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Troj...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2009.12.002

    authors： Clark AJ,Petty HR

    更新日期：2010-01-01 00:00:00

  • Immature T lymphocytes in human neonatal blood.

    abstract：:Thirty-two cord blood samples taken after caesarean section or vaginal delivery and concurrent venous blood samples obtained from normal adult controls were evaluated using monoclonal antibodies. The percentage of circulating pan-T-cell+ lymphocytes was significantly lower in cord blood (46%) compared with adult contr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90069-3

    authors： Solinger AM

    更新日期：1985-04-15 00:00:00

  • Inhibition of murine suppressor cell function by progesterone.

    abstract：:The effects of progesterone on murine suppressor cell function generated in allogeneic MLCs were investigated. BALB/c splenic lymphocytes stimulated in vitro with C3H/He cells significantly suppressed the proliferative response of BALB/c lymphocytes in a secondary MLC. This suppression was highly specific for the sens...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90377-5

    authors： O'Hearn M,Stites DP

    更新日期：1983-03-01 00:00:00

  • Simultaneous production of T helper-1-like cytokines and cytolytic activity by tumor-specific T cells in ovarian and breast cancer.

    abstract：:Cytotoxic T-cell (CTL) cultures were generated from five ovarian cancer patients (OvCTL) and from three breast cancer patients (BrCTL). All CTL lines were T-cell receptor (TcR) alphabeta+ and predominantly CD8+ (73 +/- 13%). These CTL lines preferentially recognized autologous tumor cells in an HLA class I-restricted,...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.1055

    authors： Goedegebuure PS,Douville CC,Doherty JM,Linehan DC,Lee KY,Ganguly EK,Eberlein TJ

    更新日期：1997-02-01 00:00:00