Abstract:
:The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-A∗24:02-positive patient, who failed to eliminate CMV for more than 1 year after HSCT, responded poorly to CMV pp65 peptide and showed high PD-1 expression. Sera from patients with persistent CMV infection showed a significantly higher IL-6 level than those from patients with temporary CMV infection after allogeneic HSCT and healthy donors. CD33+ adherent cells produced IL-6, and regulated PD-1 expression and growth of CMV-specific CD8+ T cells through cell-to-cell contact. Although further investigation is required to clarify the association between IL-6 level and CMV infection in more patients, IL-6 might be a useful biomarker of persistent CMV infection after allogeneic HSCT.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Kato T,Nishida T,Ito Y,Murase M,Murata M,Naoe Tdoi
10.1016/j.cellimm.2014.02.007subject
Has Abstractpub_date
2014-03-01 00:00:00pages
53-9issue
1-2eissn
0008-8749issn
1090-2163pii
S0008-8749(14)00033-1journal_volume
288pub_type
杂志文章abstract::Respiratory immunization is an attractive way to generate systemic and mucosal protective memory responses that are required for preventing mucosally transmitted infections. However, the molecular and cellular mechanisms for controlling memory T cell responses remain incompletely understood. In this study, we investig...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2016.07.006
更新日期:2016-12-01 00:00:00
abstract::Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are major proinflammatory cytokines inducing the synthesis and release of many inflammatory mediators. They are involved in immune regulation, autoimmune diseases, and inflammation. Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene d...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0154
更新日期:1996-06-15 00:00:00
abstract::OVA-specific T cells were immortalized by infection with radiation leukemia virus (RadLV). Some clones derived from such population were shown to exhibit helper activity. We then tested clones without such function and found among them some that secreted macrophage migration inhibition factor (MIF) and leukocyte migra...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90328-x
更新日期:1986-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1984-04-15 00:00:00
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journal_title:Cellular immunology
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更新日期:2017-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1605
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90003-2
更新日期:1988-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90190-1
更新日期:1989-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1303
更新日期:1993-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90093-7
更新日期:1990-02-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1099
更新日期:1997-04-10 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2011.06.012
更新日期:2011-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.2000.1671
更新日期:2000-07-10 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90291-2
更新日期:1988-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1116
更新日期:1993-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cellimm.2012.09.001
更新日期:2012-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2007.05.002
更新日期:2007-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90199-1
更新日期:1986-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.03.003
更新日期:2008-01-01 00:00:00
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更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1624
更新日期:2000-03-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90272-4
更新日期:1989-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1991-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.2001.1883
更新日期:2001-11-25 00:00:00
abstract::Adoptive immunotherapy is a promising cancer treatment that entails infusion of immune cells manipulated to have antitumor specificity, in vitro. Antigen-specific cytotoxic T lymphocytes are the main executors of transformed cells during cancer immunotherapy. To induce antigen-specific cytotoxic T lymphocytes, we deve...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2018.10.002
更新日期:2018-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90177-1
更新日期:1984-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1048
更新日期:1994-02-01 00:00:00
abstract::Conditioned medium (CM) from 24-hr culture of guinea pig L2C B lymphoblastic leukemia cells contained an inhibitor(s) of mitogen- and antigen-stimulated proliferation of syngeneic (strain 2 guinea pigs), allogeneic (Hartley guinea pigs), and xenogeneic (Balb/c mouse, NZW rabbit) lymphocytes. The proliferation of sever...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90087-6
更新日期:1987-04-01 00:00:00