The role of suppressor factors in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes. II. Activity of suppressor cell culture sonicates.

abstract：:To determine whether human antibody responses to T cell-independent pneumococcal polysaccharide antigens are derived from CD5+ or CD5- B cells, we utilized an ELISPOT assay to detect individual anti-polysaccharide antibody-secreting cells. Human anti-type IV pneumococcal polysaccharide antibody-secreting cells were fo...

journal_title：Cellular immunology

authors： Barrett DJ,Sleasman JW,Schatz DA,Steinitz M

更新日期：1992-08-01 00:00:00

abstract：:Adoptive immunotherapy is a promising cancer treatment that entails infusion of immune cells manipulated to have antitumor specificity, in vitro. Antigen-specific cytotoxic T lymphocytes are the main executors of transformed cells during cancer immunotherapy. To induce antigen-specific cytotoxic T lymphocytes, we deve...

journal_title：Cellular immunology

authors： Shao J,Xu Q,Su S,Wei J,Meng F,Chen F,Zhao Y,Du J,Zou Z,Qian X,Liu B

更新日期：2018-12-01 00:00:00

abstract：:The murine T cell hybridoma line, MBI-1.15, secretes a 17-kDa protein which decreases binding activity of the CD23 molecule for its natural ligand, IgE. This protein, denoted epsilon receptor-modulating protein (epsilon RMP), was previously characterized and shown to be a novel serine protease. The present studies sho...

journal_title：Cellular immunology

authors： Matsushita S,Katz DH

更新日期：1994-02-01 00:00:00

abstract：:Murine peritoneal macrophages (M phi), activated in vivo or in vitro, remarkably inhibited the uptake of thymidine by a lens epithelial cell line, while resident M phi, or M phi induced by thioglycollate, exhibited much lower or no cytostatic capacity. The target cells were partially protected from the cytostatic acti...

journal_title：Cellular immunology

authors： Mochizuki M,Zigler JS Jr,Russell P,Gery I

更新日期：1984-01-01 00:00:00

abstract：:Immunization with synthetic mRNA encoding tumor-associated antigens is an emerging vaccine strategy for the treatment of cancer. In order to prevent mRNA degradation, promote antigen-presenting cells antigen presentation, and induce an anti-tumor immune response, we investigated the nasal administration of mRNA vaccin...

journal_title：Cellular immunology

authors： Mai Y,Guo J,Zhao Y,Ma S,Hou Y,Yang J

更新日期：2020-08-01 00:00:00

abstract：:Immunosuppression is a well-established risk factor for Visceral Leishmaniasis. Post-immunosuppression leishmaniasis is characterized by an increase of parasite burden, hematopoietic disorders and unusual clinical manifestations. Although there are many reports on bone marrow findings in VL, less is known about the re...

journal_title：Cellular immunology

authors： Carvalho-Gontijo R,Moreira DR,Resende M,Costa-Silva MF,Peruhype-Magalhães V,Ribeiro CMF,Ribeiro DD,Silvestre R,Cordeiro-da-Silva A,Martins-Filho OA,Teixeira-Carvalho A

更新日期：2018-04-01 00:00:00

abstract：:The poor immunogenicity of many tumors can be partly explained by the inefficiency of the MHC class I peptide presentation pathway. MHC-I-based single-chain trimers (SCT) represent a new class of molecules with the potential to overcome this limitation. We here evaluated the ability of SCT presenting a melanoma antige...

journal_title：Cellular immunology

authors： Ordaz ML,Larmonier N,Lybarger L

更新日期：2010-01-01 00:00:00

abstract：:The development of B cell tolerance is believed to involve negative signaling to B cells derived from the binding of antigen to the B cell surface immunoglobulin. B cell lines that receive negative signals may provide useful models for studying the mechanisms of B cell tolerance. We have established a human B lymphoma...

journal_title：Cellular immunology

authors： Komada Y,Zhang XL,Zhou YW,Tanaka S,Higashigawa M,Ido M,Sakurai M

更新日期：1994-12-01 00:00:00

abstract：:We have studied the evolution of thyroiditis induced by neonatal thymectomy in Buffalo strain rats, with particular emphasis on the thyroid lymphocytic infiltrate. The earliest change was increased endothelial Ia expression, and infiltration of the thyroid at 5 weeks by ED1- and ED2-positive macrophages and B and T ce...

journal_title：Cellular immunology

authors： Cohen SB,Dijkstra CD,Weetman AP

更新日期：1988-06-01 00:00:00

abstract：:We have studied the antibody-induced effect of cross-linking the major histocompatibility complex class I (MHC-I) in human T leukemic cells (Jurkat) and human B lymphoma cells (Solubo, Burkitts lymphoma) on intracellular [Ca2+]i levels. The increase in [Ca2+]i after MHC-I cross-linking in Jurkat cells and Solubo cells...

journal_title：Cellular immunology

authors： Pedersen AE,Jacoby BF,Skov S,Claesson MH

更新日期：1996-11-01 00:00:00

abstract：:The transfer of B cells from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess...

journal_title：Cellular immunology

authors： Baker PJ,Taylor C,Fauntleroy MB,Stashak PW,Prescott B

更新日期：1985-12-01 00:00:00

abstract：:Although ligation of the T-cell antigen receptor (TCR) is central to the responsiveness and antigen specificity of T-cells, it is insufficient to elicit a response. To determine whether the need for costimulation reflects inadequate strength of signal transduction through the TCR or an absolute block of signaling in t...

journal_title：Cellular immunology

authors： Adler B,Ashkar S,Cantor H,Weber GF

更新日期：2001-05-25 00:00:00

abstract：:Attempts have been made to induce cytolytic T cells to kill target cells that do not express the appropriate target molecules by crosslinking the T cells and the target cells in various ways. One successful strategy has been to use heteroconjugates or bispecific monoclonal antibodies reacting with T cell molecules wit...

journal_title：Cellular immunology

authors： Hedlund G,Dohlsten M,Lando PA,Kalland T

更新日期：1990-09-01 00:00:00

abstract：:We examined the effects of the inhibitors of C1q or collagen biosynthesis, 2,2'-dipyridyl (DP), and 3,4-dehydro-DL-proline (DHP) on murine macrophage (M phi) FcR subclass-mediated antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis of sheep erythrocyte targets. Oil-elicited peritoneal M phi from C3HeB/FeJ...

journal_title：Cellular immunology

authors： Mocharla R,Mocharla H,Leu RW

更新日期：1987-03-01 00:00:00

abstract：:Stimulation via the CD3/TCR molecular complex induces proliferation of resting T cells, but triggers programmed cell death (apoptosis) in immature thymocytes and preactivated mature T cells. Activation-induced cell death (AICD) triggered by anti-CD3/TCR mAb or by staphylococcus enterotoxin superantigen is associated w...

journal_title：Cellular immunology

authors： Pohl T,Pechhold K,Oberg HH,Wilbert OM,Kabelitz D

更新日期：1995-12-01 00:00:00

abstract：:Thymic (T) or bursal (B) lymphocytes from chicks sensitized to Mycobacterium tuberculosis produce an avian lymphocyte inhibitory factor (LyIF). The physiochemical properties of both T and B LyIF were established by ultrafiltration which yielded four fractions with molecular weight ranges of greater than 100,000; 50,00...

journal_title：Cellular immunology

authors： Martin DE,Glick B

更新日期：1983-07-15 00:00:00

abstract：:Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to...

journal_title：Cellular immunology

authors： Halperin D,Reuben C,Ben-Efraim S,Grover N,Weiss DW

更新日期：1985-05-01 00:00:00

abstract：:Peroxynitrite (ONOO(-)) has been vastly implicated in mutagenesis and cancer development. Present study probes the antigenicity of peroxynitrite damaged DNA (ONOO(-)-DNA) in cancer patients. Purified human placental DNA was damaged by the synergistic action of sodium nitroprusside (SNP) and Pyrogallol for 3h at 37 deg...

journal_title：Cellular immunology

authors： Habib S,Moinuddin,Ali A,Ali R

更新日期：2009-01-01 00:00:00

abstract：:The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is...

journal_title：Cellular immunology

authors： Fidelus RK

更新日期：1988-04-15 00:00:00

abstract：:This study was conducted on human K562 lymphocytes to investigate the mechanisms implicated in the regulation of the serotonin transport process. The uptake of serotonin in these cells was saturable (Km, 3.37 microM; Vmax, 2.03 nmol/10(6) cells) and Na+ dependent; isoosmotic replacement of Na+ with choline chloride in...

journal_title：Cellular immunology

authors： Khan NA,Meyneil JP,Deschaux P

更新日期：1996-09-15 00:00:00

abstract：:Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline ...

journal_title：Cellular immunology

authors： Leng SX,Margolick JB

更新日期：2020-02-01 00:00:00

abstract：:Abnormalities in immune response play a major role in the increased susceptibility to infection after hemorrhage and trauma. Infections occurring after injury often originate in the intestine. In order to determine the effects of hemorrhage on intestinal B cell function, we examined hemorrhage-induced alterations in a...

journal_title：Cellular immunology

authors： Abraham E,Chang YH

更新日期：1990-06-01 00:00:00

abstract：:Our strategy to use saturation mutagenesis to produce an unbiased collection of major histocompatibility class I mutants has resulted in unpredicted mutant phenotypes. First, we have shown data supporting our earlier work of the Dp20(Y27N) mutant. Allorecognition is altered at the clonal level while no variation in ly...

journal_title：Cellular immunology

authors： Murray R,Katoh K,Alexander J,Muller D,Pederson K,Frelinger JA

更新日期：1990-06-01 00:00:00

abstract：:Using analogues of arginine to inhibit nitric oxide (NO.) production, investigators have demonstrated the intermediary role of NO. in a variety of physiological events including the antimicrobial activity exhibited by macrophages in vitro. In an effort to establish the effector function of NO. in the antimicrobial act...

journal_title：Cellular immunology

authors： Gregory SH,Sagnimeni AJ,Wing EJ

更新日期：1994-02-01 00:00:00

abstract：:Interleukin-4 (IL-4) acts directly on purified human peripheral blood B cells cultured in the presence of Epstein-Barr virus (EBV) to induce IgE secretion and to enhance the secretion of IgG and IgM. Interferon-gamma (IFN-gamma) inhibits IgE secretion in this system, without affecting the secretion of the other Ig iso...

journal_title：Cellular immunology

authors： Thyphronitis G,Banchereau J,Heusser C,Tsokos GC,Levine AD,Finkelman FD

更新日期：1991-04-01 00:00:00

abstract：:When guinea pigs were treated by complete Freund's adjuvant (CFA), eosinophil-directed chemotactic inhibitory factor (ECIF) appeared in the serum of the treated animals. The inhibition of the response of eosinophils by ECIF was selective for the T cell-derived chemotactic factor, which has been isolated from DNP-ascar...

journal_title：Cellular immunology

authors： Hirashima M,Tashiro K,Hayashi H

更新日期：1984-11-01 00:00:00

abstract：:We have previously demonstrated that natural killer (NK) cells are lysosome-rich and stain more intensely with lysosomotropic agents such as neutral red and quinacrine (Qu) than do non-NK cells. In this study we combined the quantitation of Qu staining with surface marker staining to define subpopulations of NK cells....

journal_title：Cellular immunology

authors： Shau H,Gray D,Mitchell MS

更新日期：1988-08-01 00:00:00

abstract：:In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...

journal_title：Cellular immunology

authors： Leghmari K,Contreras X,Moureau C,Bahraoui E

更新日期：2008-01-01 00:00:00

abstract：:Immunohistochemistry and flow cytometry analyses were performed to characterize the specific T cell subpopulations infiltrating basal cell carcinomas (BCC) and to determine their phenotypic response to in vitro expansion with IL-2. Tumor-infiltrating lymphocytes (TIL) within BCC predominantly expressed the CD45RO (act...

journal_title：Cellular immunology

authors： Nguyen QH,Moy RL,Roth MD,Yamamoto R,Tomono S,Dubinett SM

更新日期：1993-02-01 00:00:00

abstract：:This study was designed to investigate the regulatory role of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 (IL-6) fusion protein (Hyper-IL-6) in the differentiation of human myeloid and erythroid progenitors by a serum-free liquid suspension culture system, using the human cord blood-derived CD34(+)CD38(-...

journal_title：Cellular immunology

authors： Yu Z,Liu W,Liu D,Fan L

更新日期：2006-05-01 00:00:00