Abstract:
:Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to the usual nonspecific immunopotentiating influence of MER on the primary production of antibodies (generation of specific plaque-forming cells) in vitro to sheep red blood cells. The defect was expressed by B lymphocytes and splenic macrophages, but not by splenic T lymphocytes or peritoneal exudate macrophagic cells. Impaired responsiveness by spleen cells from MER-immunized animals to nonspecific immunostimulation was also expressed with regard to another, unrelated biological response modifier, lipopolysaccharide. There was no impairment of responsiveness to polyclonal mitogenic stimulation. Possible mechanisms of the effects described are discussed.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Halperin D,Reuben C,Ben-Efraim S,Grover N,Weiss DWdoi
10.1016/0008-8749(85)90021-8subject
Has Abstractpub_date
1985-05-01 00:00:00pages
404-13issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(85)90021-8journal_volume
92pub_type
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