Arginine analogues suppress antigen-specific and -nonspecific T lymphocyte proliferation.

abstract：:A majority (42/62) of TCR2+ interleukin 2-dependent human T lymphocyte clones was found concordantly to express not only the CD28 co-receptor structure at the cell surface but also its ligand B7. Interactions between CD28 and B7 can have important consequences for T cell activation, particularly in providing "signal 2...

journal_title：Cellular immunology

authors： Friccius H,Siegels-Hübenthal P,Rehbein A,Schlotz E,Pawelec G

更新日期：1993-10-15 00:00:00

abstract：:Possible causes were examined for the inability of heat-inactivated lymphocytes to induce proliferative responses in mixed-lymphocyte cultures (MLC). Cells heated at 45 degrees C for 60 min lost greater than 90% of their capacity to stimulate in primary (1 degree) or secondary (2 degrees) MLC. This was not due to acce...

journal_title：Cellular immunology

authors： Boyer CM,Kostyu DD,Brissette CS,Amos DB

更新日期：1986-09-01 00:00:00

abstract：:In this study a panel of monoclonal antibodies was used to investigate the kinetics of the appearance of activation-linked surface determinants as well as cytoplasmic and nuclear determinants in human T cells following lectin stimulation. Well known activation markers, such as Ia/DR, transferrin receptor, IL-2 recepto...

journal_title：Cellular immunology

authors： Holter W,Majdic O,Liszka K,Stockinger H,Knapp W

更新日期：1985-02-01 00:00:00

abstract：:It has been reported that granulocyte/macrophage colony-stimulating factor (GM-CSF), one of the hemopoietic growth factors which regulates the function of phagocytic cells, is a potent activator of cultured macrophages and induces antimicrobial activities as well as differentiation of precursor cells. In this study, w...

journal_title：Cellular immunology

authors： Yamamoto Y,Klein TW,Tomioka M,Friedman H

更新日期：1997-02-25 00:00:00

abstract：:The interaction between Newcastle disease virus (NDV) and the suppressor cell circuit which regulates the induction phase of contact sensitivity reaction to picryl chloride (Pcl) was investigated. NDV infection impairs the activity of the T suppressor afferent cells (Ts-aff) which inhibit DNA synthesis in the draining...

journal_title：Cellular immunology

authors： Dieli F,Colonna Romano G,Abrignani S,Colizzi V,Salerno A

更新日期：1985-08-01 00:00:00

abstract：:A thymic epithelial cell line (tsTNC-1) that maintains the ability to selectively bind and internalize immature alpha beta TCRloCD4+CD8+ thymocytes in vitro was used in the development of a monoclonal antibody that is specific to the cell surface of thymic nurse cells (TNCs) in the thymus. The rat monoclonal antibody ...

journal_title：Cellular immunology

authors： Pezzano M,King KD,Philp DD,Adeyemi A,Gardiner B,Yang J,Samms M,Boto W,Guyden JC

更新日期：1998-05-01 00:00:00

abstract：:Eighty-seven murine monoclonal antibodies (MAb) produced against human tumors of various origins and representing six different immunoglobulin classes were tested for antitumor reactivity in antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) assays. Mouse splenocytes, thio...

journal_title：Cellular immunology

authors： Herlyn D,Herlyn M,Steplewski Z,Koprowski H

更新日期：1985-04-15 00:00:00

abstract：:The purpose of this project was to characterize changes in murine T lymphocyte subpopulations during thymic atrophy induced by protein malnutrition and to determine the role of elevated serum corticosterone in this process. A suitable animal model was generated by placing mice on protein-sufficient (PS) and protein-de...

journal_title：Cellular immunology

authors： Barone KS,O'Brien PC,Stevenson JR

更新日期：1993-04-15 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) from cattle vaccinated with Bacillus Calmette-Guerin (BCG) were obtained and expanded in vitro by incubation with purified protein derivative. The ability of these cells to modulate the replication of virulent Mycobacterium bovis in autologous-infected macrophages was compare...

journal_title：Cellular immunology

authors： Denis M,Wedlock DN,Buddle BM

更新日期：2004-11-01 00:00:00

abstract：:In this study, the major histocompatibility complex-unrestricted cytotoxic effectors elicited in human peripheral blood mononuclear cells (PBMC) by a mannoprotein (MP) component from the cell wall of the human indigenous microorganism Candida albicans have been compared with those obtained by stimulation with interleu...

journal_title：Cellular immunology

authors： Ausiello CM,Palma C,Spagnoli GC,Piazza A,Casciani CU,Cassone A

更新日期：1989-07-01 00:00:00

abstract：:Tegumentary leishmaniasis (TL) constitutes a major public health problem with significant morbidity worldwide. Synthetic peptide-based vaccines are attractive candidates to protect against leishmaniasis, since T cell-specific epitopes can be delivery to antigen-presenting cells, leading to the generation of a Th1 cell...

journal_title：Cellular immunology

authors： Martins VT,Lage DP,Duarte MC,Carvalho AM,Costa LE,Mendes TA,Vale DL,Menezes-Souza D,Roatt BM,Tavares CA,Soto M,Coelho EA

更新日期：2017-03-01 00:00:00

abstract：:Mice that differ at Igh loci and the reagents that permit resolution of such distinctions are powerful genetic tools for studying B cell heterogeneity. In this report, IgM-allotype-specific ELISA revealed that two of three sources of mice designated as BALB.nude express the Igh-6b (IgMb) allotype characteristic of C57...

journal_title：Cellular immunology

authors： Riggs JE

更新日期：1993-05-01 00:00:00

abstract：:Large suppressive macrophages (LSM) were induced by restimulating spleen cells from rats with experimental autoimmune myasthenia gravis (EAMG) in vitro, with the autoantigen acetylcholine receptor (AChR) in the presence of cyclosporine A. LSM, purified from these cultures, are extremely potent suppressors of AChR-stim...

journal_title：Cellular immunology

authors： McIntosh KR,Drachman DB

更新日期：1999-04-10 00:00:00

abstract：:Like the thymus, the bursa of Fabricius is a site of massive lymphopoiesis accompanied by cell death in vivo. In the present study we have, therefore, examined whether chicken bursa and thymus cells exhibit apoptosis. Bursa and thymus cells from SC chickens, 4-10 weeks of age, were incubated for 8-24 hr with various r...

journal_title：Cellular immunology

authors： Asakawa J,Tsiagbe VK,Thorbecke GJ

更新日期：1993-03-01 00:00:00

abstract：:Recent evidence highlighted the role of Toll-like receptors (TLRs) as key recognition structures of the innate immune system. The activation of TLRs initiates the production of inflammatory cytokines, chemokines, tissue destructive enzymes, and type I interferons. In addition, TLR signalling plays an important role in...

journal_title：Cellular immunology

authors： Brentano F,Kyburz D,Schorr O,Gay R,Gay S

更新日期：2005-02-01 00:00:00

abstract：:The expression of HLA Class II antigens by resting and phytohemagglutinin (PHA)-activated T cells and their functional properties in autologous mixed-lymphocyte reactions (MLR) were investigated in patients with chronic active hepatitis, with alcoholic cirrhosis, and with primary biliary cirrhosis. In all groups of pa...

journal_title：Cellular immunology

authors： Scudeletti M,Indiveri F,Pierri I,Picciotto A,Ferrone S

更新日期：1986-10-01 00:00:00

abstract：:In an attempt to better relate specific membrane characteristics of human adult and cord blood lymphocytes to specific functional activities, the phenotypic differences that exist in these two populations have been examined. Cord blood cells have considerably more spontaneous suppressor cell activity than adult cells....

journal_title：Cellular immunology

authors： Johnson C,Dwyer JM

更新日期：1983-10-01 00:00:00

abstract：:Depletion of macrophages from human peripheral blood mononuclear cells (PBMC) caused a marked decrease in galactose oxidase and sodium periodate, but not a calcium ionophore, stimulated Interferon-gamma (IFN-gamma) production. Reconstitution of such depleted cultures with galactose oxidase treated macrophages, but not...

journal_title：Cellular immunology

authors： Antonelli G,Blalock JE,Dianzani F

更新日期：1985-09-01 00:00:00

abstract：:The regulation of the migratory capacity of Percoll-purified large granular lymphocytes (LGL) into nitrocellulose filters was studied in a 2-hr assay with the use of modified Boyden chambers. Compounds that stimulate the natural killer cytotoxic function of LGL, such as interferons (natural beta, recombinant alpha A, ...

journal_title：Cellular immunology

authors： Polentarutti N,Bottazzi B,Balotta C,Erroi A,Mantovani A

更新日期：1986-08-01 00:00:00

abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...

journal_title：Cellular immunology

authors： Gallily R,Sher T,Ben-Av P,Loewenstein J

更新日期：1989-06-01 00:00:00

abstract：:Optical imaging is a valuable tool to visualise biological processes in the context of the tissue. Each imaging modality provides the biologist with different types of information - cell dynamics and migration over time can be tracked with time-lapse imaging (e.g. intra-vital imaging); an overview of whole tissues can...

journal_title：Cellular immunology

authors： Husna N,Gascoigne NRJ,Tey HL,Ng LG,Tan Y

更新日期：2019-10-01 00:00:00

abstract：:A decapeptide (1182-1191) derived from the bovine interphotoreceptor retinoid-binding protein (IRBP) was found to contain two completely distinct antigenic sites when tested in Lewis rats. One site, localized in sequence 1182-1191, is the core of the immunodominant and highly uveitogenic determinant of IRBP. The secon...

journal_title：Cellular immunology

authors： Kotake S,Sasamoto Y,Kawano Y,Sanui H,Wiggert B,Chader GJ,Gery I

更新日期：1992-03-01 00:00:00

abstract：:We have previously used human Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines for the identification and purification of a novel cytokine, natural killer cell stimulatory factor (NKSF/IL-12), that has pleiotropic effects on human lymphocytes. B cell lines are also routinely employed as feeder cells fo...

journal_title：Cellular immunology

authors： Valiante NM,Rengaraju M,Trinchieri G

更新日期：1992-11-01 00:00:00

abstract：:Males exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4+ T-cell (auto)immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (β-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4+ T cells from female a...

journal_title：Cellular immunology

authors： Vujnović I,Pilipović I,Jasnić N,Petrović R,Blagojević V,Arsenović-Ranin N,Stojić-Vukanić Z,Djordjević J,Leposavić G

更新日期：2019-02-01 00:00:00

abstract：:The role of macrophages (M phi) and that of splenic dendritic cells (DC) in the allogeneic mixed leukocyte reaction (MLR) in the mouse have been investigated. In contrast with the high stimulatory capacity of DC, we obtained no evidence in favor of the competence of M phi, whether Ia + or Ia-, as an autonomous stimula...

journal_title：Cellular immunology

authors： Naito K,Komatsubara S,Kawai J,Mori K,Muramatsu S

更新日期：1984-10-15 00:00:00

abstract：:The susceptibility of murine embryonic cells to CTL lysis has been assessed. Zona-free blastocysts were not lysed during 6 hr incubation with CTL sensitized against the embryonic genotype and remained capable of implantation and normal development in vivo as well as outgrowth in vitro. Freshly dissociated cells from p...

journal_title：Cellular immunology

authors： Croy BA,Rossant J

更新日期：1987-02-01 00:00:00

abstract：:We previously reported the amino acid sequence of the human macrophage chemotactic factor with a molecular weight of 1000 (MCF-1) was WLGREDGSE. In this study we examined the roles of MCF-1 and tumor necrosis factor (TNF) in a guinea pig delayed-type hypersensitivity (DTH) reaction. When macrophage chemotactic activit...

journal_title：Cellular immunology

authors： Higashi N,Yoshizuka N,Ohuchi A,Osawa T,Kobayashi Y

更新日期：1995-04-01 00:00:00

abstract：:This study was conducted on human K562 lymphocytes to investigate the mechanisms implicated in the regulation of the serotonin transport process. The uptake of serotonin in these cells was saturable (Km, 3.37 microM; Vmax, 2.03 nmol/10(6) cells) and Na+ dependent; isoosmotic replacement of Na+ with choline chloride in...

journal_title：Cellular immunology

authors： Khan NA,Meyneil JP,Deschaux P

更新日期：1996-09-15 00:00:00

abstract：:TH1 cytokines have recently been detected in rheumatoid arthritis (RA) and osteoarthritis (OA). For this reason we studied the TH-1-promoting cytokine IL-12 in synovial membranes from patients with RA and OA. IL-12 transcripts and protein were analyzed by reverse transcriptase-polymerase chain reaction (PCR) and immun...

journal_title：Cellular immunology

authors： Sakkas LI,Johanson NA,Scanzello CR,Platsoucas CD

更新日期：1998-09-15 00:00:00

abstract：:We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recogniz...

journal_title：Cellular immunology

authors： Vainio O,Lassila O,Cihak J,Lösch U,Houssaint E

更新日期：1990-01-01 00:00:00