Abstract:
:The interaction between Newcastle disease virus (NDV) and the suppressor cell circuit which regulates the induction phase of contact sensitivity reaction to picryl chloride (Pcl) was investigated. NDV infection impairs the activity of the T suppressor afferent cells (Ts-aff) which inhibit DNA synthesis in the draining lymph nodes of mice specifically sensitized with Pcl and the development of contact sensitivity. The inhibitory effect of NDV was evident when the virus was administered up to 2 days before or at the same time as the injection of picrylsulfonic acid; this effect required infectious virus, as NDV inactivated by ultraviolet irradiation failed to inhibit Ts-aff activity. Taken together with the previous finding that the T suppressor efferent cell is unaffected by NDV, the present results support the view that contact sensitivity reaction to picryl chloride is regulated by two distinct T-suppressor-cell circuits.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Dieli F,Colonna Romano G,Abrignani S,Colizzi V,Salerno Adoi
10.1016/0008-8749(85)90099-1subject
Has Abstractpub_date
1985-08-01 00:00:00pages
225-30issue
1eissn
0008-8749issn
1090-2163pii
0008-8749(85)90099-1journal_volume
94pub_type
杂志文章abstract::Like the thymus, the bursa of Fabricius is a site of massive lymphopoiesis accompanied by cell death in vivo. In the present study we have, therefore, examined whether chicken bursa and thymus cells exhibit apoptosis. Bursa and thymus cells from SC chickens, 4-10 weeks of age, were incubated for 8-24 hr with various r...
journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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doi:10.1016/0008-8749(86)90326-6
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(92)90323-h
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
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