TLR4-dependent activation of inflammatory cytokine response in macrophages by Francisella elongation factor Tu.

abstract：:Activin A is a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily and acts as an anti-inflammatory cytokine produced by microglia and macrophages. In this study, we investigated the regulatory effect and possible mechanism of activin A on activation of lipopolysaccharide (LPS)-induced...

journal_title：Cellular immunology

authors： Zhou J,Tai G,Liu H,Ge J,Feng Y,Chen F,Yu F,Liu Z

更新日期：2009-01-01 00:00:00

abstract：:Possible causes were examined for the inability of heat-inactivated lymphocytes to induce proliferative responses in mixed-lymphocyte cultures (MLC). Cells heated at 45 degrees C for 60 min lost greater than 90% of their capacity to stimulate in primary (1 degree) or secondary (2 degrees) MLC. This was not due to acce...

journal_title：Cellular immunology

authors： Boyer CM,Kostyu DD,Brissette CS,Amos DB

更新日期：1986-09-01 00:00:00

abstract：:The fine specificity of anti-Glu60Ala30Tyr10 (GAT) and anti-Glu60Ala40 (GA) proliferating cells was studied. T cells primed with GAT proliferate both to GAT and GA and GA-primed T cells proliferate also to GA and GAT. This cross-reactivity was unexpected given the results previously reported on the fine specificity of...

journal_title：Cellular immunology

authors： Gougeon ML,Bismuth G,Leclercq L,Somme G,Thèze J

更新日期：1983-01-01 00:00:00

abstract：:Intravital imaging of cutaneous immune responses has revealed intricate links between the skin's structural properties, the immune cells that reside therein, and the carefully orchestrated migratory dynamics that enable rapid sensing and subsequent elimination of skin pathogens. In particular, the development of 2-pho...

journal_title：Cellular immunology

authors： Zaid A

更新日期：2020-04-01 00:00:00

abstract：:With old age (∼2y old), mice show substantial differences in B cell composition within the lymphoid tissues. In particular, a novel subset of IgM+ CD21/35lo/- CD23- mature B cells, the age-associated B cells or ABC, increases numerically and proportionately. This occurs at the expense of other B cell subsets, includin...

journal_title：Cellular immunology

authors： Riley RL,Khomtchouk K,Blomberg BB

更新日期：2017-11-01 00:00:00

abstract：:Interleukin 4 (IL-4)-induced IgE production by normal peripheral blood mononuclear cells (PBMC) and E- cells (PBMC partially depleted of T cells) was significantly enhanced by leukotriene B4(LTB4) in a dose-dependent manner, whereas LTB4 by itself was not effective for IgE production. The potentiating effect of LTB4 w...

journal_title：Cellular immunology

authors： Yamaoka KA,Dugas B,Paul-Eugene N,Mencia-Huerta JM,Braquet P,Kolb JP

更新日期：1994-06-01 00:00:00

abstract：:Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline ...

journal_title：Cellular immunology

authors： Leng SX,Margolick JB

更新日期：2020-02-01 00:00:00

abstract：:Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myelo...

journal_title：Cellular immunology

authors： Mundy-Bosse BL,Thornton LM,Yang HC,Andersen BL,Carson WE

更新日期：2011-01-01 00:00:00

abstract：:The expression and function of surface immunoglobulin (sIg) receptors was analyzed using antigen-specific monoclonal B cells and T cells. When B cells were incubated with antigen (hapten carrier), hapten-specific sIg receptor expression was greatly reduced. The specific antigen-presentation activity of the B cells was...

journal_title：Cellular immunology

authors： Watanabe M,Watts TH,Gariepy J,Hozumi N

更新日期：1988-03-01 00:00:00

abstract：:We previously reported the amino acid sequence of the human macrophage chemotactic factor with a molecular weight of 1000 (MCF-1) was WLGREDGSE. In this study we examined the roles of MCF-1 and tumor necrosis factor (TNF) in a guinea pig delayed-type hypersensitivity (DTH) reaction. When macrophage chemotactic activit...

journal_title：Cellular immunology

authors： Higashi N,Yoshizuka N,Ohuchi A,Osawa T,Kobayashi Y

更新日期：1995-04-01 00:00:00

abstract：:In test in vitro, four sulfated lycium barbarum polysaccharides (sLBPSs) with different degrees of sulfation (DS), sLBPS0.7, sLBPS1.1, sLBPS1.5 and sLBPS1.9, were added into cultured chicken peripheral lymphocytes and the changes of lymphocytes proliferation were compared by MTT assay taking the non-modified LBPS as c...

journal_title：Cellular immunology

authors： Wang J,Hu Y,Wang D,Liu J,Zhang J,Abula S,Zhao B,Ruan S

更新日期：2010-01-01 00:00:00

abstract：:The poor immunogenicity of many tumors can be partly explained by the inefficiency of the MHC class I peptide presentation pathway. MHC-I-based single-chain trimers (SCT) represent a new class of molecules with the potential to overcome this limitation. We here evaluated the ability of SCT presenting a melanoma antige...

journal_title：Cellular immunology

authors： Ordaz ML,Larmonier N,Lybarger L

更新日期：2010-01-01 00:00:00

abstract：:Rotavirus infection of permissive cells is a multi-step process that requires interaction with several cell surface receptors. Integrins alpha2beta1, alpha4beta1, alphaXbeta2, and alphavbeta3 are involved in the attachment and entry into permissive cells for many rotavirus strains. However, possible roles of known par...

journal_title：Cellular immunology

authors： Halasz P,Fleming FE,Coulson BS

更新日期：2005-07-01 00:00:00

abstract：:A low culture temperature of 27 degrees C inhibited mouse primary in vitro anti-hapten plaque-forming cell responses to a thymus-dependent (TD) antigen (Ag) (trinitrophenyl-keyhole limpet hemocyanin, TNP-KLH). In contrast, the magnitudes of secondary responses to TNP-KLH or primary responses to a thymus-independent (T...

journal_title：Cellular immunology

authors： Wang-Yang MC,Buttke TM,Miller NW,Clem LW

更新日期：1990-04-01 00:00:00

abstract：:Injection of antigen into the thymus of adult animals induces specific systemic tolerance, but the mechanisms of acquired thymic tolerance are not well understood. To investigate these mechanisms we used a model of intrathymic injection of ovalbumin (OVA) in BALB/c mice. We show an antigen-specific decrease in prolife...

journal_title：Cellular immunology

authors： Chen W,Issazadeh S,Sayegh MH,Khoury SJ

更新日期：1997-08-01 00:00:00

abstract：:The effect of prior maternal immunization on the murine offspring response to subsequent immunization with hen egg-white lysozyme was examined. Adult female A/J mice were immunized with 100 micrograms HEL-CFA intraperitoneally 10-27 weeks before conception. The offspring of these experimental female mice were then imm...

journal_title：Cellular immunology

authors： Jelonek MT,Brust JL,Song CH,Calandra GB,Miller A,Sercarz EE,Keller MA

更新日期：1993-05-01 00:00:00

abstract：:Mutations in the X-linked inhibitor of apoptosis (XIAP) have recently been identified in patients with the rare genetic disease, X-linked lymphoproliferative syndrome (XLP), which was previously thought to be solely attributable to mutations in a distinct gene, SAP. To further understand the roles of these two factors...

journal_title：Cellular immunology

authors： Rumble JM,Oetjen KA,Stein PL,Schwartzberg PL,Moore BB,Duckett CS

更新日期：2009-01-01 00:00:00

abstract：:Inflammatory leukocytes of DA-to-WF rat renal allografts displayed significant cytolytic activity to natural killer (NK) target cells on Day 2 after transplantation. The NK activity, which was associated with large granular lymphocytes in discontinuous Percoll gradients, peaked on Day 4 and disappeared rapidly thereaf...

journal_title：Cellular immunology

authors： Nemlander A,Soots A,Häyry P

更新日期：1984-12-01 00:00:00

abstract：:At concentrations as low as 10(-7) M, the cardiotonic glycosteroid ouabain, a specific inhibitor of the membrane Na+, K+-ATPase, is known to inhibit in vitro human lymphocyte proliferation produced in mixed lymphocyte cultures or induced by various stimulating agents (PHA, Con A, PWM, soluble antigens), while mouse ly...

journal_title：Cellular immunology

authors： Dornand J,Favero J,Bonnafous JC,Mani JC

更新日期：1984-02-01 00:00:00

abstract：:A B lymphoblastoid cell line can provide a comitogenic, accessory signal for mitogen-treated T cells. In a study evaluating the antigenic determinant of such cells that mediate this effect, a monoclonal antibody (I57) was raised against the Daudi cell line. This antibody was found to interact with a 30-kDa protein on ...

journal_title：Cellular immunology

authors： Hardy B,Dotan D,Novogrodsky A

更新日期：1989-01-01 00:00:00

abstract：:Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with Corynebacterium parvum. These immune splenocytes could b...

journal_title：Cellular immunology

authors： Chang AE,Perry-Lalley DM,Shu S

更新日期：1989-05-01 00:00:00

abstract：:Exogenous nonreplicating antigens (Ag) incorporated into immunostimulating complexes (iscoms) induce CTL responses under MHC class I restriction. A requirement for inducing CTL responses is that the Ag is delivered to the cytosol of antigen-presenting cells (APC), a route restricted to endogenously produced Ag. To inv...

journal_title：Cellular immunology

authors： Villacres MC,Behboudi S,Nikkila T,Lovgren-Bengtsson K,Morein B

更新日期：1998-04-10 00:00:00

abstract：:The proapoptotic caspase adaptor protein (PACAP) is involved in cell-cycle regulation and promotes apoptosis. Both MGC29506 and PACAP are isoforms of the MGC29506 gene and are generated by differential splicing of the alternative splice-acceptor. In studying PACAP, we inadvertently constructed the eukaryotic expressio...

journal_title：Cellular immunology

authors： Xia L,Shen C,Fu Y,Tian L,Chen M

更新日期：2013-01-01 00:00:00

abstract：:Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the 1.7-kb 3' open reading frame (ORF) mRNA encoding MTV superantigen. B...

journal_title：Cellular immunology

authors： Gayama S,Doyon L,Vaupel B,Sekaly RP,Kanagawa O

更新日期：1998-08-01 00:00:00

abstract：:CD40 and its ligand (CD40L) regulate several cellular functions, including T and B-cell activation. The soluble form of CD40 (sCD40) antagonizes CD40/CD40L interaction. Patients undergoing hemodialysis (HD) present elevated sCD40 serum levels, which underlying molecular mechanisms are unknown. We studied sCD40 serum a...

journal_title：Cellular immunology

authors： Esposito P,Rampino T,Gregorini M,Gabanti E,Bianzina S,Dal Canton A

更新日期：2012-07-01 00:00:00

abstract：:There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since...

journal_title：Cellular immunology

authors： Ortega MT,Xie L,Mora S,Chapes SK

更新日期：2011-01-01 00:00:00

abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

journal_title：Cellular immunology

authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

更新日期：1995-05-01 00:00:00

abstract：:The role of protein synthesis during the activation of macrophages (M phi) by lymphokines (LK) was studied. Peritoneal murine macrophages elicited by proteose-peptone (pM phi) were activated with LK (supernatants from normal mouse spleen cells pulsed with concanavalin A) and tested for cytotoxicity in an 18 hr assay a...

journal_title：Cellular immunology

authors： Blasi E,Varesio L

更新日期：1984-04-15 00:00:00

abstract：:Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral dsRNA, bacterial RNA, mitochondrial RNA, endogenous necrotic cell mRNA and the synthetic dsRNA an...

journal_title：Cellular immunology

authors： Duffy KE,Lamb RJ,San Mateo LR,Jordan JL,Canziani G,Brigham-Burke M,Korteweg J,Cunningham M,Beck HS,Carton J,Giles-Komar J,Duchala C,Sarisky RT,Mbow ML

更新日期：2007-08-01 00:00:00

abstract：:The primary objective of this study was to determine whether the n-3 PUFA-mediated changes in host response to a Listeria monocytogenes infection (e.g., cytokine production and bacterial clearance) were dependent upon neutrophils. Balb/c mice were fed one of two semi-purified diets that contained either 0 or 41 g of n...

journal_title：Cellular immunology

authors： Fritsche K,Irons R,Pompos L,Janes J,Zheng Z,Brown C

更新日期：2005-05-01 00:00:00