Abstract:
:Activin A is a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily and acts as an anti-inflammatory cytokine produced by microglia and macrophages. In this study, we investigated the regulatory effect and possible mechanism of activin A on activation of lipopolysaccharide (LPS)-induced mouse peritoneal macrophages. The results showed that activin A could decrease NO release in LPS-activated mouse peritoneal macrophages, and suppressed phagocytosis and pinocytosis of mouse peritoneal macrophages stimulated by LPS in vitro and in vivo. Furthermore, activin A remarkably inhibited the expressions of CD14 and MHC II on LPS-induced mouse peritoneal macrophages, but had no significant effect on the expression of MHC I and the proliferation of mouse peritoneal macrophages. These findings suggest that activin A can down-regulate inflammatory mediator production and phagocytosis of LPS-activated macrophages via suppressing CD14 expression, and may influence the presentation of exogenous antigens via inhibiting MHC II expression. Thus, activin A might have the potential for treatment of macrophage-mediated inflammatory diseases through modulating both innate and adaptive immune responses.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Zhou J,Tai G,Liu H,Ge J,Feng Y,Chen F,Yu F,Liu Zdoi
10.1016/j.cellimm.2008.11.001subject
Has Abstractpub_date
2009-01-01 00:00:00pages
69-75issue
1-2eissn
0008-8749issn
1090-2163pii
S0008-8749(08)00193-7journal_volume
255pub_type
杂志文章abstract::Viruses are related to the etiology of periodontitis. However, the role of viruses on Th17 cells infiltration in periodontitis lesions is unknown. Therefore, we examined the effects of TLR3 ligand on CCL20, which is related to Th17 cells migration, production in human gingival fibroblasts (HGFs). Polyinosinic-polycyti...
journal_title:Cellular immunology
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更新日期:2013-05-01 00:00:00
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1993-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1989-11-01 00:00:00
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1989-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2007.02.009
更新日期:2006-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2011.06.003
更新日期:2011-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0008-8749(89)90090-7
更新日期:1989-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2013.08.007
更新日期:2013-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90163-l
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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更新日期:1986-10-01 00:00:00