Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis.

Abstract:

:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral infection. Vaccinia virus, the best characterized member of the poxviridae family, encodes a 35-kDa major secretory polypeptide termed vaccinia virus complement control protein (VCP), which is structurally related to the family of human and mouse complement control proteins. Members of the family of complement control proteins have been shown to inhibit complement-mediated opsonization of bacteria and induction of inflammatory and phagocytic responses in vitro. Insertional inactivation of the VCP gene results in attenuation of viral virulence in vivo. The role of host complement in the inflammatory response to poxvirus infection has not been systematically investigated. Prior to determining the role of VCP on inflammatory responses in vivo, we decided to investigate the role of host complement in the progression of viral infection. We have compared the effects of injection of cowpox virus, primarily a rodent virus, into footpads of congenic mice strains B10.D2/nSnJ (C5-sufficient) and B10.D2/oSnJ (C5-deficient). The effects of the injection were monitored macroscopically by measuring the specific swelling response immediately following primary injection and subsequently after reinfection and by histological examination of the stained sections of the footpads. Our results indicate that there is a significant variation in the primary response in the two different mouse strains to cowpox virus infection. The specific swelling response observed in measurements from the footpads of the B10.D2/oSnJ mice was significantly greater, persisted for a longer duration, and was accompanied by severe ulceration, edema, induration, and hemorrhaging. Reinjection of the footpads after a 3-month period, during which time the swelling had subsided and the footpad had fully recovered to its original size and appearance, showed no significant differences between the two strains. This strongly suggests that the host complement plays a significant role during the initial response to poxvirus infection.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Miller CG,Justus DE,Jayaraman S,Kotwal GJ

doi

10.1006/cimm.1995.1086

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

326-32

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(85)71086-6

journal_volume

162

pub_type

杂志文章
  • Irreversible inhibition of human natural killer cell natural cytotoxicity by modification of the extracellular membrane by the adenine nucleotide analog 5'-p-(fluorosulfonyl)benzoyl adenosine.

    abstract::Extracellular adenine nucleotides are inhibitors of the human natural killer cell line NK3.3 natural cytotoxicity activity. Natural cytotoxicity was inhibited approximately 26% by 1 mM ATP and 21% by 1 mM ADP. 5'-Adenylyl imidodiphosphate, a nonhydrolyzable ATP analog, inhibited natural cytotoxicity by 41% at a concen...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(95)80028-h

    authors: Dombrowski KE,Cone JC,Bjorndahl JM,Phillips CA

    更新日期:1995-02-01 00:00:00

  • Inhibitors of cytochrome P450 suppress tumor necrosis factor production.

    abstract::We tested the effect of different inhibitors of cytochrome P450 on tumor necrosis factor (TNF) production. Metyrapone and SKF525A (100 and 50 mg/kg, ip, respectively) suppressed serum TNF induced by cotreatment with endotoxin (LPS), (2.5 micrograms/mouse). Inhibition was independent of endogenous corticosteroids since...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1993.1209

    authors: Fantuzzi G,Cantoni L,Sironi M,Ghezzi P

    更新日期:1993-09-01 00:00:00

  • The host response in graft versus host disease. II. The emergence of host protective cells is in part determined by background genomic compatibility.

    abstract::Murine graft versus host (GVH) disease takes two forms depending on the parental/F1 strain combination employed. In an accompanying paper (Singh et al., Clin. Immunol. 151, 1993) many of the clinical features of these two forms of GVH disease are described. In addition to these clinical characteristics, acute lethal G...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1993.1220

    authors: Mann RA,Singh AB,Singh M,Jetzt AE

    更新日期:1993-10-01 00:00:00

  • Comparison of the capacity of murine and human class I MHC molecules to stimulate T cell activation.

    abstract::The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(92)90254-m

    authors: Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

    更新日期:1992-10-15 00:00:00

  • Degradation signals in ErbB-2 dictate proteasomal processing and immunogenicity and resist protection by cis glycine-alanine repeat.

    abstract::ErbB-2 is ubiquitinated and degraded when dissociated from its membrane chaperone or bound by specific antibody. Reagents which induce such degradation have demonstrated antitumor activity and may impact ErbB-2 immunogenicity. To further understand ErbB-2 degradation and immunogenicity, a glycine-alanine repeat (GAr) ...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.2001.1853

    authors: Piechocki MP,Pilon SA,Kelly C,Wei WZ

    更新日期:2001-09-15 00:00:00

  • Expression of chemokine receptors on natural killer cells in HIV-infected individuals.

    abstract::Chemokine receptors CCR5 and CXCR4 are of major importance in the pathogenesis of HIV-1 infection because they are co-receptors for human immunodeficiency virus (HIV) entry. We examined the frequency of CD3-CD56+CCR5+ and CD3-CD56+CXCR4+ in HIV-infected long-term slow progressors (SPs), HIV typical progressors (TPs) w...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2008.01.010

    authors: Jiang Y,Zhang Z,Diao Y,Jin X,Shi W,Geng W,Dai D,Zhang M,Han X,Liu J,Wang Y,Shang H

    更新日期:2008-01-01 00:00:00

  • Triggering HLA-DR molecules on human peripheral monocytes induces their death.

    abstract::Although engagement of MHC class II molecules on human monocytes triggers various cellular events, their possible role in monocyte death is yet unknown. We demonstrate that ligation of MHC class II on primary monocytes induces a rapid cell death that has all the characteristics of monocyte apoptosis, does not require ...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1998.1428

    authors: Thibeault A,Zekki H,Mourad W,Charron D,Al-Daccak R

    更新日期:1999-02-25 00:00:00

  • Two distinct porcine natural killer lytic trigger molecules as PNK-E/G7 molecular complex.

    abstract::PNK-E and G7 mAbs regulate porcine NK and ADCC activities by binding to distinct NK function-associated trigger molecules on porcine NK cells. Previous work demonstrates that PNK-E mAb binds to a 205-kDa tetrameric molecule composed of two 47-kDa peptides and two 50-kDa peptides and G7 mAb binds to a distinct 40-kDa h...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1993.1026

    authors: Wierda WG,Johnson BD,Dato ME,Kim YB

    更新日期:1993-02-01 00:00:00

  • Wip 1 inhibits intestinal inflammation in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronically intestinal autoimmune disease, the pathological mechanisms of which are not very clear. Wild type p-53 induced phosphatase 1 (Wip1), a serine/threonine protein phosphatase, has been reported to negatively reg...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2016.07.012

    authors: Zhang Q,Zhang C,Chang F,Liang K,Yin X,Li X,Zhao K,Niu Q,Tian Z

    更新日期:2016-12-01 00:00:00

  • Phorbol 12,13-dibutyrate (P(Bu)2)-treated human blood mononuclear cells bind to each other.

    abstract::Treatment of human blood mononuclear cells with nanomolar concentrations of phorbol 12,13-dibutyrate (P(Bu)2) induced their aggregation. The phenomenon was seen within a few minutes and reached its maximum manifestation after 20 min. At this time, 20-30% of unfractionated and nylon wool-passed mononuclear leukocytes w...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(83)90313-1

    authors: Patarroyo M,Biberfeld P,Klein E,Klein G

    更新日期:1983-01-01 00:00:00

  • Natural killer cell sensitivity of human lymphoid lines of B-cell origin does not correlate with tumorigenicity or with the expression of certain differentiation markers.

    abstract::Human B-cell lines derived from normal donors (LCL) or from Burkitt lymphomas (BL) were compared for their sensitivity to natural (NK) and interferon (IFN)-activated (IAK) cytotoxicity, mediated by effector cells from normal human blood. In four cases, a BL and an LCL line were derived from the same donor and had been...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(84)90382-4

    authors: Torsteinsdottir S,Masucci MG,Lenoir G,Klein G,Klein E

    更新日期:1984-07-01 00:00:00

  • Interleukin-3 and Flt3-ligand induce adhesion of Baf3/Flt3 precursor B-lymphoid cells to fibronectin via activation of VLA-4 and VLA-5.

    abstract::Adhesion of hematopoietic cells to extracellular matrix components is important for blood cell development. However, little is known regarding the potential influence of IL-3 on this process for precursor B cells and Flt3-ligand has not yet been implicated in induction of adhesion of any blood cell types to extracellu...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1998.1318

    authors: Shibayama H,Anzai N,Ritchie A,Zhang S,Mantel C,Broxmeyer HE

    更新日期:1998-07-10 00:00:00

  • Monoclonal antibody internalization and degradation during modulation of the CD3/T-cell receptor complex.

    abstract::Although it is well known that the CD3/T-cell receptor (TCR) complex modulates from the surface of T cells upon exposure to monoclonal antibodies (mAb) directed against it, the fate of bound mAb has not been yet elucidated. We therefore perform direct binding experiments of 125I-labeled mAb against CD3 or TCR to inves...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(88)90209-2

    authors: Schaffar L,Dallanegra A,Breittmayer JP,Carrel S,Fehlmann M

    更新日期:1988-10-01 00:00:00

  • Human autologous rosette-forming cells. III. Binding of erythrocytes from different species to the T-cell receptors for autologous red blood cells.

    abstract::Spontaneous rosette formation in humans is restricted to a subpopulation of the circulating T cells. We have previously shown that the interaction between lymphocytes and autologous red blood cells (auto-RBC) is not mediated by a self-recognition mechanism, since allogeneic (allo-) RBC bind to T cells through the same...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(85)90345-4

    authors: Nalet V,Fournier C

    更新日期:1985-11-01 00:00:00

  • Analysis of B-cell subpopulations. I. Relationships among splenic xid, Ly 1+, and Lyb 5+ B cells.

    abstract::The phenotypic and functional relationships among the various B-cell subsets is of importance for better understanding studies of the immune system. In this report, the realm of B cells encompassed by Lyb 5, Ly 1, and xid has been examined through the use of the alloantiserum anti-Lyb 5, the unique functional properti...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(85)90077-2

    authors: Smith HR,Yaffe LJ,Chused TM,Raveche ES,Klinman DM,Steinberg AD

    更新日期:1985-04-15 00:00:00

  • Arginine analogues suppress antigen-specific and -nonspecific T lymphocyte proliferation.

    abstract::Using analogues of arginine to inhibit nitric oxide (NO.) production, investigators have demonstrated the intermediary role of NO. in a variety of physiological events including the antimicrobial activity exhibited by macrophages in vitro. In an effort to establish the effector function of NO. in the antimicrobial act...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1994.1048

    authors: Gregory SH,Sagnimeni AJ,Wing EJ

    更新日期:1994-02-01 00:00:00

  • Divergent effects of cyclosporine A on interferon- and mitogen-induced Ly-6A antigen suggest autocrine regulation of Ly-6A expression in activated T cells.

    abstract::The murine Ly-6A cell surface antigen is normally present on a minor subset of mature T cells. This marker has been shown to become highly expressed on mitogen-activated T cells. We found that expression of Ly-6A is also markedly increased in resting T cells by incubation with IFN-alpha/beta or IFN-gamma. Here, we com...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(87)90083-9

    authors: Dumont FJ

    更新日期:1987-04-01 00:00:00

  • Prostaglandin E2 inhibits TNF production in murine bone marrow-derived dendritic cells.

    abstract::Exposure to pathogens induces dendritic cells to release inflammatory cytokines and chemokines. The inflammatory response is controlled by endogenous agents such as anti-inflammatory cytokines, glucocorticoids, anti-inflammatory neuropeptides, and lipid mediators. This study is the first report on the inhibition by pr...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/s0008-8749(03)00158-8

    authors: Vassiliou E,Jing H,Ganea D

    更新日期:2003-06-01 00:00:00

  • Altered cell-averaged microviscosity of murine peritoneal macrophages undergoing activation in vivo or in vitro.

    abstract::The cell-averaged microviscosity of intact murine peritoneal mononuclear phagocytes in various stages of activation was assessed by quantifying fluorescent depolarization of 1,6-diphenyl-1,3,5-hexatriene. Macrophages activated in vivo with Mycobacterium bovis, strain BCG, were significantly more fluid than resident pe...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(87)90026-8

    authors: Somers SD,Yuli I,Snyderman R,Adams DO

    更新日期:1987-02-01 00:00:00

  • GF109203X, a specific PKC inhibitor, abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells.

    abstract::Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus transformed B cells is mainly mediated by LFA-1 (CD11a/CD18) and CD2 molecules. Low-affinity binding of resting T cells can be transiently upregulated by cross-linking of CD3-TCR (T cell receptor) complexes. This inside-out signaling influences i...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1993.1211

    authors: Hauss P,Mazerolles F,Hivroz C,Lecomte O,Barbat C,Fischer A

    更新日期:1993-09-01 00:00:00

  • Immobilized staphylococcal enterotoxin A is sufficient to induce T cell proliferation.

    abstract::We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1993.1255

    authors: Rust CJ,Koning F,van Schooten WC

    更新日期:1993-10-15 00:00:00

  • Ontogeny and expression of non-MHC-restricted T cell antigen-binding molecules by thymocytes and peripheral T cell subsets.

    abstract::The ontogeny of T cells which express major histocompatibility complex (MHC)-unrestricted T cell antigen-binding molecules (TABM) on the cell membrane was investigated. We used a rabbit anti-mouse TABM antiserum to investigate the expression of TABM by subsets of adult thymocytes, peripheral T cells, and thymocytes du...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(90)90171-m

    authors: Rellahan BL,Cone RE

    更新日期:1990-10-01 00:00:00

  • The role of the thymus in the maintenance of natural killer cells in vivo.

    abstract::This report describes a model for investigating the role of the thymus in regulating natural killer (NK) cell activity in vivo. Evidence is presented that the thymus can regulate NK cells, and that at least some NK cells can develop without thymic help. Marrow from thymectomized rats depleted of circulating T cells by...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(85)90201-1

    authors: Flexman JP,Holt PG,Mayrhofer G,Latham BI,Shellam GR

    更新日期:1985-02-01 00:00:00

  • Delayed-type hypersensitivity to Babesia microti-infected erythrocytes in mice.

    abstract::Strong delayed-type hypersensitivity (DTH) to Babesia microti was elicited when intraerythrocytic parasites (IEP) were inoculated subcutaneously into the flank of normal mice 6 to 14 days before challenge in the ipsilateral footpad with 10(8) IEP. Intraperitoneal or intravenous administration of antigen did not sensit...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(86)90289-3

    authors: Ruebush MJ,Troutman EH,Kennedy DA

    更新日期:1986-04-01 00:00:00

  • H-2-determined kinetic differences for the induction of nucleoside-specific suppression.

    abstract::The kinetic and the H-2 requirements for the induction of nucleoside-specific suppression were examined in several strains of mice; specifically, whether adenosine (A)-coupled spleen cells given intravenously suppress the primary response to adenosine-KLH. The adenosine system was chosen because C57Bl/6 mice were orig...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(83)90333-7

    authors: Giroir BP,Raps EC,Cookson E,Borel Y

    更新日期:1983-02-01 00:00:00

  • Induction of the nitric oxide-synthesizing pathway in fresh and interleukin 2-cultured rat natural killer cells.

    abstract::Several lines of evidence suggest that nitric oxide (NO), generated through nitric oxide synthase (NOS) by cleavage of terminal guanidino nitrogen from L-arginine, mediates tumor cell killing by mononuclear phagocytes. Natural killer (NK) cells are cytotoxic effector cells that lyse a variety of tumor and virus-infect...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1994.1215

    authors: Cifone MG,Festuccia C,Cironi L,Cavallo G,Chessa MA,Pensa V,Tubaro E,Santoni A

    更新日期:1994-08-01 00:00:00

  • Interleukin-12 (IL-12) augments cytolytic activity of natural killer cells toward Mycobacterium tuberculosis-infected human monocytes.

    abstract::We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly natural killer (NK) cells) from normal and HIV-1-infected subjects on lysis of human monocytes infected with Mycobacterium tuberculosis. Nylon wool nonadherent cells stimulated with interleukin-2 (IL-2) or with IL-12 developed sig...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1994.1196

    authors: Denis M

    更新日期:1994-07-01 00:00:00

  • Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.

    abstract::B-1a cells represent a distinct B cell population with unique phenotype, self-renewing capacity and restricted Igμ repertoire. They primarily locate in body cavity and also exist in spleen. The different subpopulations of B-1a cells are heavily affected by local environment. Our previous studies revealed that MARVEL-d...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2020.104100

    authors: Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

    更新日期:2020-06-01 00:00:00

  • Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus.

    abstract::The loss of thymic function with age may be due to diminished numbers of T-cell progenitors and the loss of critical mediators within the thymic microenvironment. To assess the molecular changes associated with this loss, we examined transcriptomes of progressively aging mouse thymi, of different sexes and on caloric-...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2007.03.008

    authors: Lustig A,Weeraratna AT,Wood WW 3rd,Teichberg D,Bertak D,Carter A,Poosala S,Firman J,Becker KG,Zonderman AB,Longo DL,Taub DD

    更新日期:2007-01-01 00:00:00

  • Induction of CD8+ suppressor T cells by treatment with DMBA and TPA in vitro.

    abstract::Antigen-nonspecific CD8+ T suppressor cells, which suppressed delayed-type hypersensitivity (DTH) against sheep red blood cells in BALB/c mice, were induced by incubating spleen cells from mice treated with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, with 12-O-tetradecanoylphorbol 13-acetate (TPA), a tum...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(91)90167-a

    authors: Negoro T,Iinuma F,Watanabe M

    更新日期:1991-12-01 00:00:00