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Distinct immunologic specificity of tumor regression mediated by effector cells isolated from immunized and tumor-bearing mice.

Abstract：

:Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with Corynebacterium parvum. These immune splenocytes could be further sensitized and expanded in culture by the in vitro sensitization (IVS) method utilizing tumor stimulator cells and IL-2. Adoptive immunotherapy of pulmonary metastases mediated by noncultured splenocytes from immunized mice or immune IVS cells showed exquisite specificity between the two sarcomas. These results demonstrate the presence of tumor-specific antigens on MCA 105 and MCA 106 tumor cells which can serve as target molecules for immunotherapy. Recently, we have generated therapeutic T lymphocytes from mice bearing progressively growing tumors by the IVS method. However, IVS cells from tumor-bearing mice showed cross-reactivity between the MCA 105 and 106 sarcomas in adoptive immunotherapy experiments. Since these IVS cells did not affect other control tumors, the limited cross-reactivity suggests the presence of common tumor-associated antigens on MCA 105 and MCA 106 tumor cells which can also serve as the target for tumor rejection. Therefore, immune responses to progressive tumor growth and to immunization are distinct with respect to antigen recognition by T lymphocytes.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Chang AE,Perry-Lalley DM,Shu S

doi

10.1016/0008-8749(89)90209-8

subject

Has Abstract

pub_date

1989-05-01 00:00:00

pages

419-29

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(89)90209-8

journal_volume

120

pub_type

杂志文章

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