Induction of endogenous mammary tumor virus in lymphocytes infected with murine acquired immunodeficiency syndrome virus.

Abstract:

:Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the 1.7-kb 3' open reading frame (ORF) mRNA encoding MTV superantigen. B cell lines that are established from MAIDS mice and exhibit superantigen activity also express a high level of 1.7-kb endogenous MTV and mRNA. Infection of a B cell tumor line in vitro with retrovirus containing the cloned MAIDS virus gene induced superantigen activity and this cell line also expressed the 1.7-kb superantigen coding MTV 3' ORF mRNA. These results strongly suggest a link between MAIDS virus infection and the induction of endogenous superantigen activity. This may play an important role in the pathogenesis of the MAIDS virus.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Gayama S,Doyon L,Vaupel B,Sekaly RP,Kanagawa O

doi

10.1006/cimm.1998.1326

subject

Has Abstract

pub_date

1998-08-01 00:00:00

pages

124-30

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(98)91326-0

journal_volume

187

pub_type

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