Human natural cytotoxic lymphocytes: definition by a monoclonal antibody of a subset which kills an anchorage-dependent target cell line but not the K-562 cell line.

abstract：:Immunocytochemical staining procedures were combined with computer-aided image analysis to quantitate the relative intracellular production of tumor necrosis factor-alpha (TNF) within individual macrophages. Optimal conditions for time and methods for the activation of TNF production, fixation of cells for optimal imm...

journal_title：Cellular immunology

authors： Brown AR,Fishman M

更新日期：1990-10-15 00:00:00

abstract：:Chemotactic migration of T lymphocytes and neutrophil granulocytes within a three-dimensional collagen matrix is distinct from spontaneous, matrix-induced migration concerning dynamic parameters and regulatory intracellular signaling. Both spontaneous T lymphocyte locomotion and stromal-cell-derived factor-1 (SDF-1)-i...

journal_title：Cellular immunology

authors： Entschladen F,Gunzer M,Scheuffele CM,Niggemann B,Zänker KS

更新日期：2000-02-01 00:00:00

abstract：:The engulfment of apoptotic cells by monocytes and unprimed macrophages results in M2 polarization. In the current study, we investigated whether apoptotic cells influence the phenotypic and functional characteristics of GM-CSF-differentiated human macrophages (GM-Mφ). Our results demonstrate that GM-Mφ preincubated w...

journal_title：Cellular immunology

authors： Chernykh ER,Sakhno LV,Shevela EY,Tikhonova MA,Khonina NA,Ostanin AA

更新日期：2018-09-01 00:00:00

abstract：:Dendritic cells (DCs) link the sensing of the environment by the innate immune system to the initiation of adaptive immune responses. Accordingly, DCs are considered to be a major target in the development of immunomodulating compounds. In this study, the effect of niclosamide, a Food and Drug Administration-approved ...

journal_title：Cellular immunology

authors： Wu CS,Li YR,Chen JJ,Chen YC,Chu CL,Pan IH,Wu YS,Lin CC

更新日期：2014-03-01 00:00:00

abstract：:The objective of the present investigation was to evaluate the requirement for increased ornithine decarboxylase (ODC) activity and polyamine biosynthesis in the induction of cytolytic T lymphocytes (CTL). In this regard, we have utilized alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ODC. DFMO tre...

journal_title：Cellular immunology

authors： Bowlin TL,McKown BJ,Sunkara PS

更新日期：1987-03-01 00:00:00

abstract：:Microglia are important immunoregulatory cells within the central nervous system (CNS). Viral infection of primary microglia and splenic macrophage clones revealed that both exhibited a heterogeneous, but relatively low, sensitivity to cytolysis mediated by CD8(+) cytotoxic T lymphocytes (CTL). The majority of clones ...

journal_title：Cellular immunology

authors： Bergmann CC,Yao Q,Stohlman SA

更新日期：1999-11-25 00:00:00

abstract：:Many studies have already been reported with regard to the serological cross-reactivities between the polymorphic determinants of murine Ia antigens and human HLA-DR antigens. In this paper, we examined the biological cross-reactivity of the polymorphism of Class II antigens in the xenogeneic antigen-presenting cell (...

journal_title：Cellular immunology

authors： Yamamoto M,Yano A

更新日期：1984-09-01 00:00:00

abstract：:Mouse thyroglobulin (MTg)-sensitized spleen cells activated in vitro with MTg induced experimental autoimmune thyroiditis (EAT) in which the thyroid infiltrate consists primarily of mononuclear cells (MNC) (lymphocytic EAT). MTg-sensitized spleen cells cultured with MTg together with anti-IL2R antibody induce a granul...

journal_title：Cellular immunology

authors： McMurray RW,Hoffman RW,Tang H,Braley-Mullen H

更新日期：1996-08-25 00:00:00

abstract：:The biological effects of IL-2 are mediated through high (complex of alpha and beta chain) or intermediate (beta chain) affinity IL-2 receptors. Previously, chimeric proteins composed of IL-2 and Pseudomonas exotoxin (IL-2-PE) were shown to be specifically cytotoxic to cells bearing IL-2 receptors. It has also been sh...

journal_title：Cellular immunology

authors： Puri RK,FitzGerald D,Leland P,Kozak RW,Pastan I

更新日期：1992-09-01 00:00:00

abstract：:Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strate...

journal_title：Cellular immunology

authors： Alves AC,Ramaldes GA,Oliveira MC,Cardoso VN,Mota-Santos TA,Faria AM,Gontijo CM

更新日期：2008-01-01 00:00:00

abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...

journal_title：Cellular immunology

authors： Loo EW,Krantz MJ,Agrawal B

更新日期：2012-11-01 00:00:00

abstract：:The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...

journal_title：Cellular immunology

authors： Wu JY,Gardner BH,Kushner NN,Pozzi LA,Kensil CR,Cloutier PA,Coughlin RT,Newman MJ

更新日期：1994-04-01 00:00:00

abstract：:We have previously used human Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines for the identification and purification of a novel cytokine, natural killer cell stimulatory factor (NKSF/IL-12), that has pleiotropic effects on human lymphocytes. B cell lines are also routinely employed as feeder cells fo...

journal_title：Cellular immunology

authors： Valiante NM,Rengaraju M,Trinchieri G

更新日期：1992-11-01 00:00:00

abstract：AIMS:Evaluate the participation of IL-17 pathway in T1D pathogenesis. T helper 17 cells are potent, highly inflammatory cells that produce interleukin 17A (IL-17A), considered a mediator of various immune disorders. However, their role in Type 1 diabetes (T1D) pathogenesis in humans is not totally elucidated. METHODS:...

journal_title：Cellular immunology

authors： Fores JP,Crisostomo LG,Orii NM,Santos AS,Fukui RT,Matioli SR,de Moraes Vasconcelos D,Silva MERD

更新日期：2018-02-01 00:00:00

abstract：:The kinetics of viability of lymph node and spleen cells of mice genetically selected for "high" or "low" in vitro lymphocyte responsiveness to PHA were studied in PHA or PPD-stimulated short-term cultures. Lo/PHA cells were found to be less viable than Hi/PHA cells in unstimulated control cultures. PHA improved the v...

journal_title：Cellular immunology

authors： Stiffel C,Liacopoulos-Briot M,Decreusefond C,Lambert F

更新日期：1983-04-01 00:00:00

abstract：:The phenotypic and functional relationships among the various B-cell subsets is of importance for better understanding studies of the immune system. In this report, the realm of B cells encompassed by Lyb 5, Ly 1, and xid has been examined through the use of the alloantiserum anti-Lyb 5, the unique functional properti...

journal_title：Cellular immunology

authors： Smith HR,Yaffe LJ,Chused TM,Raveche ES,Klinman DM,Steinberg AD

更新日期：1985-04-15 00:00:00

abstract：:The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

journal_title：Cellular immunology

authors： Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

更新日期：1992-10-15 00:00:00

abstract：:The effects of LTs are mediated by GPCRs: cysLTs interact with CYSLTR1, CYSLTR2, or GPR17, and LTB4 acts via BLT1R or BLT2R. Data relating to the presence of these receptors in mature tissue mast cells are not entirely known. By confocal microscopy with image analyses and flow cytometry, we established that native rat...

journal_title：Cellular immunology

authors： Agier J,Różalska S,Wódz K,Brzezińska-Błaszczyk E

更新日期：2017-07-01 00:00:00

abstract：:T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...

journal_title：Cellular immunology

authors： Ando DG,Clayton J,Kono D,Urban JL,Sercarz EE

更新日期：1989-11-01 00:00:00

abstract：:Although engagement of MHC class II molecules on human monocytes triggers various cellular events, their possible role in monocyte death is yet unknown. We demonstrate that ligation of MHC class II on primary monocytes induces a rapid cell death that has all the characteristics of monocyte apoptosis, does not require ...

journal_title：Cellular immunology

authors： Thibeault A,Zekki H,Mourad W,Charron D,Al-Daccak R

更新日期：1999-02-25 00:00:00

abstract：:Activated macrophages are known to release a variety of immunoregulatory substances including the low-molecular-weight substances hydrogen peroxide and lactate. We report here that lactate but not hydrogen peroxide is capable of supporting a substantial production of T-cell growth factor (TCGF) in cultures of accessor...

journal_title：Cellular immunology

authors： Roth S,Dröge W

更新日期：1987-09-01 00:00:00

abstract：:The molecular mechanism responsible for the age-dependent decline of natural killer (NK) cell response was examined. The responses of NK cells to poly(I:C), Con A, and LPS were compared between the young and the aged animals. We observed that both basal and induced NK cell activity declined with age. To further determ...

journal_title：Cellular immunology

authors： Hsueh CM,Chen SF,Ghanta VK,Hiramoto RN

更新日期：1996-11-01 00:00:00

abstract：:To investigate a role for T lymphocytes in primary demyelination of central nervous system (CNS) tissue, antigen-specific T cell lines sensitized to myelin-associated and myelin-unrelated antigens were developed from SJL mice and tested on myelinated organotypic cultures of syngeneic spinal cord. Demyelination was ass...

journal_title：Cellular immunology

authors： Lyman WD,Roth GA,Chiu FC,Brosnan CF,Bornstein MB,Raine CS

更新日期：1986-10-01 00:00:00

abstract：:Simultaneous stimulation of human monocytes/macrophages or THP1 cells with LPS and an antibody specific for the activation marker CD69 induces apoptosis. Here we demonstrate the involvement of multiple independent signals that are necessary for apoptosis induction. Thus, inhibitors of phospholipase A2 and lipoxygenase...

journal_title：Cellular immunology

authors： Ramírez R,Carracedo J,Castedo M,Zamzami N,Kroemer G

更新日期：1996-09-15 00:00:00

abstract：:Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3 kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine microglia. It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) produc...

journal_title：Cellular immunology

authors： Vo TS,Ngo DH,Ta QV,Wijesekara I,Kong CS,Kim SK

更新日期：2012-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...

journal_title：Cellular immunology

authors： Zhou M,Chen J,Zhou L,Chen W,Ding G,Cao L

更新日期：2014-11-01 00:00:00

abstract：:We describe here a novel real-time cell tracking system which can measure cell migration routes under cell culture condition. This system includes a mini incubator which controls temperature and CO(2) gas flow and a PDMS (polydimethylsiloxane) chip for chemotaxis measurement. The main differences from previous ones ar...

journal_title：Cellular immunology

authors： Kwak YH,Hong SM,Park SS

更新日期：2010-01-01 00:00:00

abstract：:Two monoclonal antibodies specific for different rat T-cell subpopulations, the anti-helper-T-cell antibody, W3/25, and the OX8 suppressor cell antibody were used to investigate lectin-stimulated T-lymphocyte differentiation of F-344 rat bone marrow cells in culture. Cytofluorometric analysis of freshly isolated lymph...

journal_title：Cellular immunology

authors： Pfeifer RW,Stillman WS,Irons RD

更新日期：1983-12-01 00:00:00

abstract：:TJ6 is a novel protein which has immunosuppressive activity and may have a functional role in fetal allograft survival during pregnancy. Initial studies indicated that when mice were treated with an anti-TJ6 binding mAb early in pregnancy, the pregnancies were completely ablated and that TJ6 expression is enhanced dra...

journal_title：Cellular immunology

authors： Nichols TC,Kang JA,Angkachatchai V,Beer AE,Beaman KD

更新日期：1994-04-15 00:00:00

abstract：:Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptibl...

journal_title：Cellular immunology

authors： Speziali E,Santiago AF,Fernandes RM,Vaz NM,Menezes JS,Faria AM

更新日期：2009-01-01 00:00:00