Abstract:
:Chemotactic migration of T lymphocytes and neutrophil granulocytes within a three-dimensional collagen matrix is distinct from spontaneous, matrix-induced migration concerning dynamic parameters and regulatory intracellular signaling. Both spontaneous T lymphocyte locomotion and stromal-cell-derived factor-1 (SDF-1)-induced chemotaxis-involved protein tyrosine kinase (PTK) activity, whereas only SDF-1-induced migration was protein kinase C (PKC) dependent. Spontaneous locomotion of neutrophil granulocytes was independent of PKC and PTK activity, but formyl-methionyl-leucyl-phenylalanine-induced migration involved PKC activity. In addition, the microtubule cytoskeleton was not changed after induction of chemotaxis in both cell types. T lymphocytes had a well-developed microtubule cytoskeleton with the microtubule organizing center located in the uropod, whereas neutrophil granulocytes revealed a clustered tubulin distribution at the leading edge of the migrating cell. Therefore, differences of the microtubule cytoskeleton might contribute to differences in locomotion between T lymphocytes and neutrophil granulocytes but not to differences between spontaneous locomotion and chemotaxis.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Entschladen F,Gunzer M,Scheuffele CM,Niggemann B,Zänker KSdoi
10.1006/cimm.1999.1605subject
Has Abstractpub_date
2000-02-01 00:00:00pages
104-14issue
2eissn
0008-8749issn
1090-2163pii
S0008-8749(99)91605-2journal_volume
199pub_type
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1993-10-01 00:00:00
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journal_title:Cellular immunology
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更新日期:1993-05-01 00:00:00
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更新日期:2013-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90375-8
更新日期:1986-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.2000.1698
更新日期:2000-09-15 00:00:00
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pub_type: 杂志文章
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更新日期:1989-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2006.06.008
更新日期:2006-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90329-0
更新日期:1984-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2011.10.011
更新日期:2012-01-01 00:00:00
abstract::Multiple previous studies have demonstrated significant alterations of immunologic parameters associated with mouse hepatitis virus (MHV) infection, but effects of the virus on mucosal lymphoid cells have not been examined. Coincident with a natural outbreak of MHV at our institution, we noted alterations in immunoglo...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90295-4
更新日期:1987-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.11.001
更新日期:2009-01-01 00:00:00
abstract::It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90270-x
更新日期:1987-06-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0218
更新日期:1996-08-25 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
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更新日期:2011-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2010.02.011
更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90021-8
更新日期:1985-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90309-5
更新日期:1984-02-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90111-0
更新日期:1987-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90296-0
更新日期:1986-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1991-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90007-x
更新日期:1988-04-15 00:00:00
abstract::Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strate...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.07.001
更新日期:2008-01-01 00:00:00