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Protective effect of chitin oligosaccharides against lipopolysaccharide-induced inflammatory response in BV-2 microglia.

Abstract：

:Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3 kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine microglia. It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) production by suppressing the expression of NO synthase (iNOS) and cyclooxygenase (COX)-2 without significant cytotoxicity. Furthermore, the inhibitory effects of NA-COS on generation of interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α were determined. Notably, NA-COS exerted anti-inflammatory activities via blocking degradation of inhibitor of kappaB-alpha (IκB-α), translocation of nuclear factor (NF)-κB, and phosphorylation of mitogen-activated protein kinases (MAPKs) in a dose-dependent manner. These findings provide mechanistic insights into the anti-inflammatory and neuroprotective actions of NA-COS in BV-2 microglia.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Vo TS,Ngo DH,Ta QV,Wijesekara I,Kong CS,Kim SK

doi

10.1016/j.cellimm.2012.06.005

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

14-21

issue

1-2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(12)00117-7

journal_volume

277

pub_type

杂志文章

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