Immunoregulation by natural killer cells.

Abstract:

:Polyinosinic-polycytidilic acid (poly (I:C], a synthetic analog of viral double-stranded RNA (dsRNA), activates natural killer (NK) cells and inhibits induction or promotes termination of the primary IgM response in vivo. Suppression of responses was reproduced in vivo by interferons (IFN) which activate NK cells and in vitro by cells enriched for NK cells. The likelihood that NK cells may be involved in the normal regulation of IgM responses is supported by the following observations: immunization itself induces NK activity at times appropriate to account for termination, NK cells activated by immunization suppress in vitro, mice with high NK activity induced by immunization with one antigen have reduced responses to immunization with a second antigen, and mice with induced loss of NK activity fail to down-regulate IgM antibody responses normally.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Abruzzo LV,Mullen CA,Rowley DA

doi

10.1016/0008-8749(86)90287-x

subject

Has Abstract

pub_date

1986-04-01 00:00:00

pages

266-78

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(86)90287-X

journal_volume

98

pub_type

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