Interleukin-10 production by B cells is regulated by cytokines, but independently of GATA-3 or FoxP3 expression.

abstract：:A variant nonkiller (K-) T-cell clone derived from the MHC nonrestricted killer (K+) cell line TALL-103/2 (CD3/TCR gamma delta +) was studied to determine whether its lytic defects were at the tumor-binding or post-binding level. The two TALL-103/2 clones were found to display similar mRNA expression of TCR/CD3 comple...

journal_title：Cellular immunology

authors： Visonneau S,Cesano A,Santoli D

更新日期：1995-10-15 00:00:00

abstract：:Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strate...

journal_title：Cellular immunology

authors： Alves AC,Ramaldes GA,Oliveira MC,Cardoso VN,Mota-Santos TA,Faria AM,Gontijo CM

更新日期：2008-01-01 00:00:00

abstract：:AK-5 is a spontaneously regressing rat histiocytoma and the tumor regression is mediated by CD8+ NK cells. We have investigated the functional status of effector cells mediating complete remission of the tumor. The effector-target interaction takes place with the help of antibody to AK-5 and the mechanism of lysis inv...

journal_title：Cellular immunology

authors： Bright JJ,Hegde SP,Begum Z,Khar A

更新日期：1994-03-01 00:00:00

abstract：:Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

journal_title：Cellular immunology

authors： Chrobak P,Gress RE

更新日期：2001-03-15 00:00:00

abstract：:In this study a panel of monoclonal antibodies was used to investigate the kinetics of the appearance of activation-linked surface determinants as well as cytoplasmic and nuclear determinants in human T cells following lectin stimulation. Well known activation markers, such as Ia/DR, transferrin receptor, IL-2 recepto...

journal_title：Cellular immunology

authors： Holter W,Majdic O,Liszka K,Stockinger H,Knapp W

更新日期：1985-02-01 00:00:00

abstract：:A series of anti-DNA antibody-producing hybridomas were obtained by fusing spleen cells from 6-month-old MRL/lpr, autoimmune prone, mice with P3X63-Ag8 myeloma cells. Rabbit anti-idiotype (id) antibodies specific for several of the hybridoma proteins were prepared. It was shown that the anti-id antibody inhibited immu...

journal_title：Cellular immunology

authors： Kim YT,Puntillo E,DeBlasio T,Weksler ME,Siskind GW

更新日期：1987-03-01 00:00:00

abstract：:In vivo treatment with anti-IA antibodies has been shown to induce a haplotype-specific inhibition of EAE when the disease was following passive transfer of MBP-sensitized T cells. In order to determine the mechanism by which anti-IA antibody prevents passively transferred EAE, the homing of radiolabeled cells to the ...

journal_title：Cellular immunology

authors： Sriram S,Carroll L

更新日期：1991-06-01 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curable strategy for the treatment of hematological malignancies and nonmalignant diseases. However, graft-versus-host disease (GVHD) and relapse are still two major causes of morbidity and mortality after allo-HSCT, and both restrict the improvement ...

journal_title：Cellular immunology

authors： Gu G,Yang JZ,Zhang JQ,Sun LX

更新日期：2019-12-01 00:00:00

abstract：:Ferric ammonium citrate (FAC) is nonmitogenic for human peripheral blood mononuclear cells (PBM) but has a potent mitogenic activity in the presence of IL-2. FAC in the presence of IL-2 increases the number of human peripheral blood mononuclear cells (PBM) expressing receptors for IL-2 and transferrin. FAC also marked...

journal_title：Cellular immunology

authors： Novogrodsky A,Suthanthiran M,Stenzel KH

更新日期：1991-04-01 00:00:00

abstract：:We evaluated the role of molecules of the major histocompatibility complex (MHC) involved in the cellular interactions of two T-cell clones by testing the effect of monoclonal antibodies on the responses of the clones in vitro. The two T-cell clones used in the study are specific for minor histocompatibility antigens ...

journal_title：Cellular immunology

authors： Brückner T,Di Pauli R

更新日期：1986-04-15 00:00:00

abstract：:In the search for its role in inflammatory joint diseases, soluble HLA-DR (sHLA-DR) was quantitated in 72 synovial fluids (SF) by a newly established immunoenzyme assay. Unlike other soluble receptors which accumulated only moderately (sCD25, sCD4) or negligibly (sHLA class I, sCD8) in the SF, SF sHLA-DR levels exceed...

journal_title：Cellular immunology

authors： Claus R,Bittorf T,Walzel H,Brock J,Uhde R,Meiske D,Schulz U,Hobusch D,Schumacher K,Witt M,Bartel F,Hausmann S

更新日期：2000-12-15 00:00:00

abstract：:Natural killer (NK) cells play an important role in innate and adaptive immune responses to obligate intracellular pathogens. Nevertheless, the regulation of NK cell trafficking and migration to inflammatory sites is poorly understood. Exodus-1/MIP-3alpha/LARC, Exodus-2/6Ckine/SLC, and Exodus-3/MIP-3beta/ELC/CKbeta-11...

journal_title：Cellular immunology

authors： Robertson MJ,Williams BT,Christopherson K 2nd,Brahmi Z,Hromas R

更新日期：2000-01-10 00:00:00

abstract：:To determine the contribution of B cells to brain myelin injury in Semliki Forest Virus (SFV) encephalomyelitis, normal C57BL/6 (B6) and B-cell-deficient (C57BL/6-tm1Cgn) B6 mice were infected with SFV. The peak of clinical disease, i.e., the time at which the greatest proportions of mice had moderate to severe clinic...

journal_title：Cellular immunology

authors： Smith-Norowitz TA,Sobel RA,Mokhtarian F

更新日期：2000-02-25 00:00:00

abstract：:Medicinal plants are considered immunomodulatory as they display various biological activities. There is no report addressing the anti-inflammatory effects of Daphne gnidium. In this study, we investigated the effects of D. gnidium ethyl acetate (EA) leaf extract on mice immune cell function in vitro. Production of pr...

journal_title：Cellular immunology

authors： Harizi H,Chaabane F,Ghedira K,Chekir-Ghedira L

更新日期：2011-01-01 00:00:00

abstract：:The immediate effects and mechanisms of desensitization of contact sensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) were investigated. Mice were sensitized with DNFB, desensitized with antigen 2 weeks later, and challenged 1 day after desensitization. Significant inhibition (approximately 50%) of contact sensitivity ...

journal_title：Cellular immunology

authors： Mekori YA,Claman HN

更新日期：1984-11-01 00:00:00

abstract：:Monoclonal-nonspecific suppressor factor (MNSF) is a lymphokine derived from murine T cell hybridoma. The target tissues are both LPS-stimulated B cells and Con A-stimulated T cells. Since the action of MNSF may be mediated by its binding to specific cell surface receptors, we characterized the mode of this binding. T...

journal_title：Cellular immunology

authors： Nakamura M,Ogawa H,Tsunematsu T

更新日期：1990-10-15 00:00:00

abstract：:The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...

journal_title：Cellular immunology

authors： Heidenreich S,Kubis T,Schmidt M,Fegeler W

更新日期：1994-09-01 00:00:00

abstract：:It has been reported that granulocyte/macrophage colony-stimulating factor (GM-CSF), one of the hemopoietic growth factors which regulates the function of phagocytic cells, is a potent activator of cultured macrophages and induces antimicrobial activities as well as differentiation of precursor cells. In this study, w...

journal_title：Cellular immunology

authors： Yamamoto Y,Klein TW,Tomioka M,Friedman H

更新日期：1997-02-25 00:00:00

abstract：:Staphylococcal enterotoxin B (SEB) is a potent polyclonal activator of both human and murine T cells. We previously reported data which show that SEB-induced T cells suppress antibody secretion by various mouse plasmacytoma cell lines. This suppression of antibody secretion was found to be both idiotype and isotype no...

journal_title：Cellular immunology

authors： Newcomb JR,Lin YS,Rogers TJ

更新日期：1990-09-01 00:00:00

abstract：:Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate...

journal_title：Cellular immunology

authors： Tang R,Langdon WY,Zhang J

更新日期：2019-06-01 00:00:00

abstract：:Human peripheral blood cells enriched for B lymphocytes were stimulated to focal proliferation in semisolid cultures with lymphocyte-conditioned media, Protein A (Prot A), lipopolysaccharide (LPS) and 2-mercaptoethanol (2-ME). After 6-8 days of incubation, two morphologically distinct colony types were observed. Type ...

journal_title：Cellular immunology

authors： Peschel C,Gattringer C,Konwalinka G,Geissler D,Boyd J,Huber H,Braunsteiner H

更新日期：1984-10-01 00:00:00

abstract：:Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBlo, CD44hi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this lymphokine. Several groups have reported an increase, with age, in the secretion of IL-4 in short...

journal_title：Cellular immunology

authors： Li SP,Miller RA

更新日期：1993-10-01 00:00:00

abstract：:Curcumin has commonly been used for the treatment of various allergic diseases. However, its precise anti-allergic rhinitis effect and mechanism remain unknown. In the present study, the effect of curcumin on allergic responses in ovalbumin (OVA)-induced allergic rhinitis mouse was investigated. We explored the effect...

journal_title：Cellular immunology

authors： Zhang N,Li H,Jia J,He M

更新日期：2015-11-01 00:00:00

abstract：:Interleukins play a role in the process of T-cell development and, like other cytokines, seem able to modulate apoptosis. Interleukin-2 has been reported to inhibit apoptotic cell death of thymocytes induced in vitro by either activation of CD3/TCR complex or treatment with glucocorticoid hormone. We demonstrate here ...

journal_title：Cellular immunology

authors： Migliorati G,Nicoletti I,Pagliacci MC,D'Adamio L,Riccardi C

更新日期：1993-01-01 00:00:00

abstract：:Mice infected with murine acquired immunodeficiency syndrome (MAIDS) virus developed lymphoadenopathy and profound immunodeficiency. Concomitantly the expression of endogenous mammary tumor virus (MTV) mRNA increased significantly, especially for the 1.7-kb 3' open reading frame (ORF) mRNA encoding MTV superantigen. B...

journal_title：Cellular immunology

authors： Gayama S,Doyon L,Vaupel B,Sekaly RP,Kanagawa O

更新日期：1998-08-01 00:00:00

abstract：:Investigation into the mechanism of action of vaccine adjuvants provides opportunities to define basic immune principles underlying the induction of strong immune responses and insights useful for the rational development of subunit vaccines. A novel HIV vaccine composed of plasmid DNA-encoding p55 gag formulated with...

journal_title：Cellular immunology

authors： Denis-Mize KS,Dupuis M,Singh M,Woo C,Ugozzoli M,O'Hagan DT,Donnelly JJ 3rd,Ott G,McDonald DM

更新日期：2003-09-01 00:00:00

abstract：:MHC class II-restricted antigen presentation requires trafficking of newly synthesized class II-invariant chain complexes from the trans-Golgi network to endosomal, peptide-loading compartments. This transport is mediated by dileucine-like motifs within the cytosolic tail of the invariant chain. Although these signals...

journal_title：Cellular immunology

authors： Sevilla LM,Richter SS,Miller J

更新日期：2001-06-15 00:00:00

abstract：:Varying the concentration of anti-CD3 immobilized on Sepharose beads allowed us to study both the inhibitory and the stimulatory effects of IL-4 on purified T cells and contrast IL-4 versus IL-2-driven T-cell proliferative responses. In the presence of low density immobilized anti-CD3, IL-4 was unable to stimulate pur...

journal_title：Cellular immunology

authors： Jones-Tiffany LA,Mehrotra PT,Horohov DW,Siegel J,Kozak RW

更新日期：1993-04-01 00:00:00

abstract：:Cyclosporin A (CsA) was tested for its modulatory effects on the mIgM-mediated signaling of G0*-associated increases in class II MHC expression, G1-related RNA synthesis, and S phase-related DNA synthesis in human B cells. While CsA at concentrations as low as 10-100 ng/ml could completely ablate anti-IgM-induced DNA ...

journal_title：Cellular immunology

authors： Mongini PK,Blessinger CA,Dalton JP,Seki T

更新日期：1992-04-01 00:00:00

abstract：:The Interferon-inducible gene IFI16, a member of the HIN200 family, is activated by oxidative stress and cell density, in addition to Interferons, and it is implicated in the regulation of endothelial cell proliferation and vessel formation in vitro. We have previously shown that IFI16 is required for proinflammatory ...

journal_title：Cellular immunology

authors： Sponza S,De Andrea M,Mondini M,Gugliesi F,Gariglio M,Landolfo S

更新日期：2009-01-01 00:00:00