Abstract:
:Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strategy is the usage of liposomes. Different parameters may influence the stability of liposomes in the gastrointestinal tract. Herein, we studied the immunological consequences of oral administration of liposome-encapsulated ovalbumin in different strains of mice using different liposomes. Our data demonstrated that ovalbumin liposomes improved the induction of oral immunization and the degree of improvement depended on the liposome type and on the strain of mice used. The mechanism responsible for this differential effect of liposomes depended on the site of antigen release and absorption. Therefore, some liposomes might be suitable as adjuvants for oral immunization, others for oral tolerance induction.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Alves AC,Ramaldes GA,Oliveira MC,Cardoso VN,Mota-Santos TA,Faria AM,Gontijo CMdoi
10.1016/j.cellimm.2008.07.001subject
Has Abstractpub_date
2008-01-01 00:00:00pages
63-73issue
1eissn
0008-8749issn
1090-2163pii
S0008-8749(08)00133-0journal_volume
254pub_type
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
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