Abstract:
:Daudi Burkitt's lymphoma cells stimulate the proliferation of Vgamma2 Vdelta2 T cells in human peripheral blood mononuclear cells (PBMC). Transfection studies have established that the gammadelta T cell receptor is sufficient for recognition of a ligand associated with Daudi cells. Since other studies have demonstrated the need for cooperation between alphabeta T cells and Vgamma2 Vdelta2 T cells in the proliferative response to mycobacterial antigens, we used human, unfractionated PBMC and PBMC depleted of specific T cell subsets to determine whether the gammadelta T cell response to Daudi cells also requires cooperation between alphabeta and gammadelta T cells. In the current study, we demonstrate that depletion of CD4+ T cells substantially reduces the overall proliferative response of PBMC to Daudi cells and subsequent gammadelta T cell expansion. IL-2 production by PBMC in response to Daudi cells was also decreased by depletion of CD4+ T cells, but not by depletion of CD8+ or gammadelta T cells. In the CD4+ T-cell-depleted PBMC, proliferation in response to Daudi cells was restored by the addition of IL-2. These data stress the importance of cooperation between alphabeta and gammadelta T cells in the response to some complex antigens.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Burns J,Lobo S,Bartholomew Bdoi
10.1006/cimm.1996.0289subject
Has Abstractpub_date
1996-11-25 00:00:00pages
19-24issue
1eissn
0008-8749issn
1090-2163pii
S0008-8749(96)90289-0journal_volume
174pub_type
杂志文章abstract::This study was conducted to investigate the effects of sex hormones upon the nature of soluble immune response suppressor (SIRS) produced by concanavalin A-stimulated Lyt-2+ T cells. Conventional SIRS affected IgM PFC only. However, SIRS made with progesterone (20-400 ng/ml or Prog-SIRS) suppressed IgM PFC, one-way ML...
journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90091-1
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1992-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90114-7
更新日期:1990-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1995-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1314
更新日期:1994-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90242-9
更新日期:1984-01-01 00:00:00
abstract::Functional helper and suppressor hybridomas were constructed from fractionated Type II NFR/nude mouse splenocytes which resemble precursors of T cells. After carrier priming with rabbit erythrocytes (RE), splenocytes from Type II NFR/nude mice were fractionated on nylon wool columns. Cells from two distinct fractions ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90329-0
更新日期:1984-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0008-8749(83)90313-1
更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s0008-8749(02)00577-4
更新日期:2002-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(91)90118-u
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2011.10.009
更新日期:2012-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00
abstract::The severity of influenza increases with age, with worse disease in aged males than females. Testosterone concentrations decline with age in males, which may impact influenza pathogenesis. Aged male mice were treated with testosterone or placebo and outcomes during influenza A virus (IAV) infection were compared with ...
journal_title:Cellular immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1987-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1989-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90095-6
更新日期:1989-09-01 00:00:00
abstract::Cells from the draining lymph nodes of DBA/2 mice bearing syngeneic intradermal P-815 tumors represent an excellent responding cell population for secondary stimulation in vitro, despite the virtual absence of response by spleen cells of the same animals. Cytotoxicity is a result of stimulation with intact mitomycin-t...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(83)90255-1
更新日期:1983-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90068-2
更新日期:1987-03-01 00:00:00