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Stimulation of different pathways of T-cell functions by syngeneic tumor cells and soluble membrane proteins.

Abstract：

:Cells from the draining lymph nodes of DBA/2 mice bearing syngeneic intradermal P-815 tumors represent an excellent responding cell population for secondary stimulation in vitro, despite the virtual absence of response by spleen cells of the same animals. Cytotoxicity is a result of stimulation with intact mitomycin-treated tumor cells. Isolated tumor cell membranes, in the form of small vesicles, stimulated cytotoxicity to a very limited extent and inhibited the development of cytotoxic T lymphocytes over a wide range of concentrations. Membrane proteins solubilized with deoxycholate and papain had only a suppressive effect. Soluble proteins exerted their effect during the induction of cytotoxic T lymphocytes and were ineffective when present during the effector phase of cytotoxic T lymphocytes. The suppressive capacity was shown to reside in a cell population which was sensitive to treatment with monoclonal Lyt-2.1 antibody and complement but not with Lyt-1.1 antibody. This phenotype was compatible with a specific rather than a promiscuous type of suppressor effector cell.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Bertschmann M,Lüscher EF

doi

10.1016/0008-8749(83)90255-1

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

13-22

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(83)90255-1

journal_volume

78

pub_type

杂志文章

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