Interleukin-10 enhances gamma delta T cell development in the murine fetal thymus.

abstract：:Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to...

journal_title：Cellular immunology

authors： Halperin D,Reuben C,Ben-Efraim S,Grover N,Weiss DW

更新日期：1985-05-01 00:00:00

abstract：:In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...

journal_title：Cellular immunology

authors： Denis M

更新日期：1992-04-15 00:00:00

abstract：:The molecular mechanism responsible for the age-dependent decline of natural killer (NK) cell response was examined. The responses of NK cells to poly(I:C), Con A, and LPS were compared between the young and the aged animals. We observed that both basal and induced NK cell activity declined with age. To further determ...

journal_title：Cellular immunology

authors： Hsueh CM,Chen SF,Ghanta VK,Hiramoto RN

更新日期：1996-11-01 00:00:00

abstract：:Non-obese diabetic (NOD) mice develop spontaneous T-cell responses against pancreatic beta-cells, leading to islet cell destruction and diabetes. Despite high genetic similarity, non-obese resistant (NOR) mice do not develop diabetes. We show here that spleen cells of both NOD and NOR mice respond to the islet cell an...

journal_title：Cellular immunology

authors： Ott PA,Anderson MR,Tary-Lehmann M,Lehmann PV

更新日期：2005-05-01 00:00:00

abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

journal_title：Cellular immunology

authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

更新日期：2002-05-01 00:00:00

abstract：:The first step of Ig heavy chain class switch recombination (CSR) is considered to be DNA double strand break (DSB) formation in the two switch (S) regions (S(mu) and downstream S(H)), although the underlying mechanism is unknown. Recently, it has been demonstrated that at least Spo11, a homolog of the novel type II t...

journal_title：Cellular immunology

authors： Tokuyama H,Tokuyama Y

更新日期：2000-05-25 00:00:00

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curable strategy for the treatment of hematological malignancies and nonmalignant diseases. However, graft-versus-host disease (GVHD) and relapse are still two major causes of morbidity and mortality after allo-HSCT, and both restrict the improvement ...

journal_title：Cellular immunology

authors： Gu G,Yang JZ,Zhang JQ,Sun LX

更新日期：2019-12-01 00:00:00

abstract：:Mutations in the X-linked inhibitor of apoptosis (XIAP) have recently been identified in patients with the rare genetic disease, X-linked lymphoproliferative syndrome (XLP), which was previously thought to be solely attributable to mutations in a distinct gene, SAP. To further understand the roles of these two factors...

journal_title：Cellular immunology

authors： Rumble JM,Oetjen KA,Stein PL,Schwartzberg PL,Moore BB,Duckett CS

更新日期：2009-01-01 00:00:00

abstract：:We describe here a culture system for studying the development, in vitro, of antigen-specific CD4 T cells from unprimed mice. T cells from young mice are initially exposed to antigen, such as pigeon cytochrome C or keyhole limpet hemocyanin, in the presence of adherent accessory cells and then allowed to proliferate i...

journal_title：Cellular immunology

authors： Dozmorov I,Miller RA

更新日期：1997-06-15 00:00:00

abstract：:We have recently established a new animal model for primary Sjögren's syndrome in NFS/sld mutant mice thymectomized 3 days after birth (3dTX) bearing an autosomal recessive gene with sublingual gland differentiation arrest. In this study, we analyze developing mechanisms of experimental autoimmune sialadenitis (EAS) i...

journal_title：Cellular immunology

authors： Hayashi Y,Haneji N,Hamano H,Yanagi K,Takahashi M,Ishimaru N

更新日期：1996-08-01 00:00:00

abstract：:Coxsackievirus group B type 3 (CVB3) induces myocarditis in male Balb/c mice but produces little cardiac injury in females. Males develop cytolytic T lymphocytes (CTL) reactive to heart antigens which primarily cause the inflammation and cardiac injury observed in the disease. Infected female mice lack this CTL respon...

journal_title：Cellular immunology

authors： Job LP,Lyden DC,Huber SA

更新日期：1986-03-01 00:00:00

abstract：:The purpose of this study was to determine whether multiple types of suppressor factors play a role in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes (UV Ts). The UV Ts were induced by applying contact allergens to the ventral, unirradiated skin of mice exposed 5 days earl...

journal_title：Cellular immunology

authors： Yee GK,Ullrich SE,Kripke ML

更新日期：1989-06-01 00:00:00

abstract：:The systemic adoptive transfer of activated T cells, derived from tumor-draining lymph nodes (LNs), mediates the regression of established tumors. In this study, the requirement of cell adhesion molecules, CD11a/CD18 (LFA-1), CD54 (ICAM-1), CD49d/CD29 (VLA-4), and CD106 (VCAM-1), for T cell infiltration into tumors an...

journal_title：Cellular immunology

authors： Mukai S,Kagamu H,Shu S,Plautz GE

更新日期：1999-03-15 00:00:00

abstract：:Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...

journal_title：Cellular immunology

authors： Bradstock KF,Kerr A,Bollum FJ

更新日期：1985-02-01 00:00:00

abstract：:The purpose of this study is to assess the potential of dendritic cells transfected with PD-L1 recombinant adenovirus induces CD8+ T cell suppression and kidney allograft tolerance. To prove it, DCs transfected with PD-L1 recombinant adenovirus (DC/Ad-PD-L1) were transferred into the MHC-mismatched rat kidney transpla...

journal_title：Cellular immunology

authors： Peng W,Ran B,Ma Y,Huang X,Chang Q,Wang X

更新日期：2011-01-01 00:00:00

abstract：:In this study a panel of monoclonal antibodies was used to investigate the kinetics of the appearance of activation-linked surface determinants as well as cytoplasmic and nuclear determinants in human T cells following lectin stimulation. Well known activation markers, such as Ia/DR, transferrin receptor, IL-2 recepto...

journal_title：Cellular immunology

authors： Holter W,Majdic O,Liszka K,Stockinger H,Knapp W

更新日期：1985-02-01 00:00:00

abstract：:The bacterial determinants of pulmonary Francisella induced inflammatory responses and their interaction with host components are not clearly defined. In this study, proteomic and immunoblot analyses showed presence of a cytoplasmic protein elongation factor Tu (EF-Tu) in the membrane fractions of virulent Francisella...

journal_title：Cellular immunology

authors： Sharma J,Mishra BB,Li Q,Teale JM

更新日期：2011-01-01 00:00:00

abstract：:This study examined the characteristics of functional anergy of natural killer cells (NK) following their interaction with target cells. Purified NK cells were cocultured with K562 for 15 min or 4 hr to allow for binding of targets to NK cells. The resulting NK-target conjugates were then dissociated by EDTA, and the ...

journal_title：Cellular immunology

authors： Jewett A,Bonavida B

更新日期：1995-01-01 00:00:00

abstract：:The interaction between Newcastle disease virus (NDV) and the suppressor cell circuit which regulates the induction phase of contact sensitivity reaction to picryl chloride (Pcl) was investigated. NDV infection impairs the activity of the T suppressor afferent cells (Ts-aff) which inhibit DNA synthesis in the draining...

journal_title：Cellular immunology

authors： Dieli F,Colonna Romano G,Abrignani S,Colizzi V,Salerno A

更新日期：1985-08-01 00:00:00

abstract：:It is still a matter of debate, whether tolerance toward self-non-MHC antigens is due to intrathymic deletion or to regulatory processes in the periphery. To further pursue this question, responsiveness toward TNP and an anti-TNP monoclonal antibody (Sp6) carrying a recurrent idiotype was evaluated in prenatally trini...

journal_title：Cellular immunology

authors： Zöller M

更新日期：1990-03-01 00:00:00

abstract：:To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7 days after oral challenge with a concomitant decrea...

journal_title：Cellular immunology

authors： Dourado LP,Noviello Mde L,Alvarenga DM,Menezes Z,Perez DA,Batista NV,Menezes GB,Ferreira AV,de Souza Dda G,Cara DC

更新日期：2011-01-01 00:00:00

abstract：:Neuroinflammation plays a pivotal role in the incidence and progression of Alzheimer's disease (AD). Cathelicidin-related antimicrobial peptide (CRAMP) is critically involved in the innate neuronal responses of chronic neuroinflammation in AD and thus plays a key role in the disease. Here, we show that Aβ42 induced mi...

journal_title：Cellular immunology

authors： Xu X,Cai X,Zhu Y,He W,Wu Q,Shi X,Fang Y,Pei Z

更新日期：2018-09-01 00:00:00

abstract：:The in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on the production and utilization of interleukin-2 (IL-2) by normal human peripheral blood mononuclear cells (PBMC) was evaluated by measuring IL-2 concentrations in supernatants from PHA-stimulated PBMC cultures. Drugs were ...

journal_title：Cellular immunology

authors： Viora M,Camponeschi B

更新日期：1995-07-01 00:00:00

abstract：:Previous studies have shown that supernatants from concanavalin A-stimulated human peripheral blood mononuclear cells and isolated Leu-2 suppressor/cytotoxic T cells are chemotactic for Leu-3 helper/inducer T cells. The current study shows that lymphocyte chemotactic factor (LCF) is also produced following antigen (te...

journal_title：Cellular immunology

authors： Potter JW,Van Epps DE

更新日期：1986-01-01 00:00:00

abstract：:Castration of normal male mice leads to splenic enlargement and expansion of the B cell population. Since the spleen does not express receptors for androgens, these changes are most likely mediated by effects of androgens on other target organs. Two potential sites of androgen-mediated effects on B cells are evaluated...

journal_title：Cellular immunology

authors： Viselli SM,Reese KR,Fan J,Kovacs WJ,Olsen NJ

更新日期：1997-12-15 00:00:00

abstract：:Putative monocytic myeloid-derived suppressor cells (mMDSC; lineage-HLA-DR-/lo) were generated in 7-day cultures from normal rhesus macaque bone marrow (BM) cells in GM-CSF and IL-6. Three subsets were identified based on their differential expression of CD14, CD33, CD34 and CD11b. Following flow sorting, assessment o...

journal_title：Cellular immunology

authors： Zahorchak AF,Perez-Gutierrez A,Ezzelarab MB,Thomson AW

更新日期：2018-07-01 00:00:00

abstract：:Although TGF-β and IL-6 would turn CD8(+) T cells to differentiate into non-cytotoxic state, these treated cells were converted to cytolytic phenotypes after re-exposure to their antigenic epitope in vitro. Here, using spleen cells from TCR transgenic mice expressing TCRαβ genes of clone RT1 recognizing an epitope pep...

journal_title：Cellular immunology

authors： Takaku S,Nakagawa Y,Owaki A,Shimizu M,Takahashi M,Takahashi H

更新日期：2012-12-01 00:00:00

abstract：:Some further aspects of B-lymphocyte-promotor factor (B-LPF) activity have been studied. This activity was present in the supernatants of certain helper-T-cell lines, and it induced polyclonal activation of Ig+ B cells into Ig-secreting cells. It was found that B-LPF induced polyclonal, terminal B-cell differentiation...

journal_title：Cellular immunology

authors： Reininger L,Fueri J,Boned A,Prat M,Landolfo S,Rubin B

更新日期：1985-04-15 00:00:00

abstract：:Antigen-nonspecific CD8+ T suppressor cells, which suppressed delayed-type hypersensitivity (DTH) against sheep red blood cells in BALB/c mice, were induced by incubating spleen cells from mice treated with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, with 12-O-tetradecanoylphorbol 13-acetate (TPA), a tum...

journal_title：Cellular immunology

authors： Negoro T,Iinuma F,Watanabe M

更新日期：1991-12-01 00:00:00

abstract：:The long-term exposure of mice to superantigen SEA using a mini-osmotic pump (SEA pump) induced a long-lasting expansion of Vbeta3+ CD4+ T cells with T helper (Th) 2 cell-type properties. Removal of the SEA pump 10 days after pump implantation did not significantly alter the level of Vbeta3+ CD4+ T cell expansion/main...

journal_title：Cellular immunology

authors： Koyanagi M,Fukada K,Uchiyama T,Yagi J,Arimura Y

更新日期：2007-08-01 00:00:00