Experimental food allergy leads to adipose tissue inflammation, systemic metabolic alterations and weight loss in mice.

Abstract:

:To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7 days after oral challenge with a concomitant decrease in epididymal adipose tissue mass. This decrease was associated with increased lipolysis and local inflammation. In adipose tissue of allergic mice there were increased leukocyte rolling and adhesion in the microvasculature, increased number of leukocytes in the tissue, especially macrophages (F4/80(+) cells) and increased pro-inflammatory cytokines levels, including TNF-α, IL-6 and CCL2. In addition, we observed low serum concentrations of triglyceride, glucose, total cholesterol and free fatty acids in the allergic mice. Our results suggest that the induction of food allergy in mice leads to adipose tissue inflammation and systemic metabolic alterations that contribute to the weight loss observed.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Dourado LP,Noviello Mde L,Alvarenga DM,Menezes Z,Perez DA,Batista NV,Menezes GB,Ferreira AV,de Souza Dda G,Cara DC

doi

10.1016/j.cellimm.2011.05.008

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

198-206

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(11)00118-3

journal_volume

270

pub_type

杂志文章
  • In vitro viability of lymphoid cells from lines of mice genetically selected for high or low responsiveness to phytohemagglutinin.

    abstract::The kinetics of viability of lymph node and spleen cells of mice genetically selected for "high" or "low" in vitro lymphocyte responsiveness to PHA were studied in PHA or PPD-stimulated short-term cultures. Lo/PHA cells were found to be less viable than Hi/PHA cells in unstimulated control cultures. PHA improved the v...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(83)90008-4

    authors: Stiffel C,Liacopoulos-Briot M,Decreusefond C,Lambert F

    更新日期:1983-04-01 00:00:00

  • DNA array and biological characterization of the impact of the maturation status of mouse dendritic cells on their phenotype and antitumor vaccination efficacy.

    abstract::We systematically investigated the impact of the relative maturation levels of dendritic cells (DCs) on their cell surface phenotype, expression of cytokines and chemokines/chemokine receptors (by DNA array and RNase protection analyses), biological activities, and abilities to induce tumor immunity. Mature DCs expres...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.2001.1883

    authors: Chen Z,Dehm S,Bonham K,Kamencic H,Juurlink B,Zhang X,Gordon JR,Xiang J

    更新日期:2001-11-25 00:00:00

  • Lipid raft-dependent endocytosis negatively regulates responsiveness of J774 macrophage-like cells to LPS by down regulating the cell surface expression of LPS receptors.

    abstract::Acting through CD14 and TLR4/MD-2, lipopolysaccharide (LPS) triggers strong pro-inflammatory activation of macrophages, which, if not appropriately controlled, may lead to lethal septic shock. Therefore, numerous mechanisms of negative regulation of responses to LPS exist, but whether they include down-regulation of L...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2016.11.008

    authors: Józefowski S,Śróttek M

    更新日期:2017-02-01 00:00:00

  • Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of B cell lines to stimulate T and NK cell proliferation.

    abstract::We have previously used human Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines for the identification and purification of a novel cytokine, natural killer cell stimulatory factor (NKSF/IL-12), that has pleiotropic effects on human lymphocytes. B cell lines are also routinely employed as feeder cells fo...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(92)90322-g

    authors: Valiante NM,Rengaraju M,Trinchieri G

    更新日期:1992-11-01 00:00:00

  • Inhibition of proinflammatory macrophage responses and lymphocyte proliferation in vitro by ethyl acetate leaf extract from Daphne gnidium.

    abstract::Medicinal plants are considered immunomodulatory as they display various biological activities. There is no report addressing the anti-inflammatory effects of Daphne gnidium. In this study, we investigated the effects of D. gnidium ethyl acetate (EA) leaf extract on mice immune cell function in vitro. Production of pr...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2010.12.002

    authors: Harizi H,Chaabane F,Ghedira K,Chekir-Ghedira L

    更新日期:2011-01-01 00:00:00

  • Studies on the relationship of human natural killer and lymphokine-activated killer cells with lysosomal staining and analysis of surface marker phenotypes.

    abstract::We have previously demonstrated that natural killer (NK) cells are lysosome-rich and stain more intensely with lysosomotropic agents such as neutral red and quinacrine (Qu) than do non-NK cells. In this study we combined the quantitation of Qu staining with surface marker staining to define subpopulations of NK cells....

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(88)90158-x

    authors: Shau H,Gray D,Mitchell MS

    更新日期:1988-08-01 00:00:00

  • CD4+CD25+ regulatory T cells control the progression from periinsulitis to destructive insulitis in murine autoimmune diabetes.

    abstract::Non-obese diabetic (NOD) mice develop spontaneous T-cell responses against pancreatic beta-cells, leading to islet cell destruction and diabetes. Despite high genetic similarity, non-obese resistant (NOR) mice do not develop diabetes. We show here that spleen cells of both NOD and NOR mice respond to the islet cell an...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2005.05.003

    authors: Ott PA,Anderson MR,Tary-Lehmann M,Lehmann PV

    更新日期:2005-05-01 00:00:00

  • Cellular activation induced by BCG is a PTK-dependent event.

    abstract::Mycobacterial antigens including BCG stimulate human peripheral blood mononuclear cells resulting in cellular proliferation and the release of inflammatory cytokines such as TNF-alpha. However, the signal transduction mechanisms responsible for the BCG-induced cell activation are not completely understood. In this stu...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1996.0185

    authors: Méndez-Samperio P,Hernandez-Garay M,Vazquez AN

    更新日期:1996-07-10 00:00:00

  • In vivo treatment with anti-ICAM-1 and anti-LFA-1 antibodies inhibits contact sensitization-induced migration of epidermal Langerhans cells to regional lymph nodes.

    abstract::Development of contact hypersensitivity in mice depends on the migration of Langerhans cells from the epidermis to regional lymph nodes. Since ICAM-1 and LFA-1 play important roles in leukocyte migration, we sought to determine whether in vivo administration of anti-ICAM-1 and anti-LFA-1 antibodies would inhibit conta...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1994.1285

    authors: Ma J,Wang JH,Guo YJ,Sy MS,Bigby M

    更新日期:1994-10-15 00:00:00

  • Burn injury suppresses human dermal dendritic cell and Langerhans cell function.

    abstract::Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering bo...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2011.01.007

    authors: van den Berg LM,de Jong MA,Witte Ld,Ulrich MM,Geijtenbeek TB

    更新日期:2011-01-01 00:00:00

  • Human peritoneal macrophages possess two populations of IgG Fc receptors.

    abstract::To characterize the binding properties of the Fc receptors on human macrophages, the binding of radiolabeled human IgG1 to peritoneal macrophages was assessed. Cells were obtained at the time of diagnostic laparoscopy from women undergoing evaluation of infertility. Macrophages bound on the average more IgG1 monomer t...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(84)90403-9

    authors: Kurlander RJ,Haney AF,Gartrell J

    更新日期:1984-07-01 00:00:00

  • Association of intermediate T cell receptor cells, mainly their NK1.1(-) subset, with protection from malaria.

    abstract::Mice were infected with Plasmodium (P.) yoelii blood-stage parasites. Both the liver and spleen were the sites of inflammation during malarial infection at the beginning of day 7. The major expanding cells were found to be NK1.1(-) intermediate alphabetaTCR (alphabetaTCR(int)) in the liver and spleen, although the pop...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.2000.1737

    authors: Weerasinghe A,Sekikawa H,Watanabe H,Mannoor K,Morshed SR,Halder RC,Kawamura T,Kosaka T,Miyaji C,Kawamura H,Seki S,Abo T

    更新日期:2001-01-10 00:00:00

  • Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.

    abstract::B-1a cells represent a distinct B cell population with unique phenotype, self-renewing capacity and restricted Igμ repertoire. They primarily locate in body cavity and also exist in spleen. The different subpopulations of B-1a cells are heavily affected by local environment. Our previous studies revealed that MARVEL-d...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2020.104100

    authors: Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

    更新日期:2020-06-01 00:00:00

  • L3T4+ T-cell-independent reactivity of Lyt2+ T cells in vivo.

    abstract::The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearanc...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(88)90059-7

    authors: Heeg K,Steeg C,Wagner H

    更新日期:1988-01-01 00:00:00

  • Calreticulin acts as an adjuvant to promote dendritic cell maturation and enhances antigen-specific cytotoxic T lymphocyte responses against non-small cell lung cancer cells.

    abstract::Dendritic cell (DC)-based immunotherapy has promising for treatment of non-small cell lung cancer (NSCLC). Melanoma-associated antigen 3 (MAGE-A3) is a tumor-specific antigen and expressed in approximately 35-40% of NSCLC tissues. Calreticulin (CALR) is a protein chaperone and can enhance DC maturation and antigen pre...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2015.12.003

    authors: Liu X,Li J,Liu Y,Ding J,Tong Z,Liu Y,Zhou Y,Liu Y

    更新日期:2016-02-01 00:00:00

  • Low versus high density of immobilized anti-CD3 influences IL-4 regulation of T-cell immune responses.

    abstract::Varying the concentration of anti-CD3 immobilized on Sepharose beads allowed us to study both the inhibitory and the stimulatory effects of IL-4 on purified T cells and contrast IL-4 versus IL-2-driven T-cell proliferative responses. In the presence of low density immobilized anti-CD3, IL-4 was unable to stimulate pur...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1993.1081

    authors: Jones-Tiffany LA,Mehrotra PT,Horohov DW,Siegel J,Kozak RW

    更新日期:1993-04-01 00:00:00

  • Effect of a local immune reaction on peripheral blood polymorphonuclear neutrophil microbicidal function: studies with fungal targets.

    abstract::Peripheral blood polymorphonuclear neutrophils (PMN) from mice immunized with Blastomyces dermatitidis and then stimulated locally (intraperitoneally, ip) with B. dermatitidis antigen had enhanced killing of B. dermatitidis in vitro (54.4 +/- 19.49 of inoculum) compared to nonimmune mice (32.7 +/- 8.7%; P less than 0....

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(87)90111-0

    authors: Morrison CJ,Brummer E,Stevens DA

    更新日期:1987-11-01 00:00:00

  • Differential recognition of tumor-derived and in vitro Epstein-Barr virus-transformed B-cell lines by fetal calf serum-specific T4-positive cytotoxic T-lymphocyte clones.

    abstract::Two interleukin-2 (IL-2)-dependent cytotoxic T-cell clones were obtained by limiting dilution from a lymphocyte culture stimulated in vitro with the autologous Epstein-Barr virus-transformed lymphoblastoid cell line (LCL) in the presence of fetal calf serum (FCS). Both clones uniformly had a T3+, T4+, Dr+ phenotype an...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(86)90304-7

    authors: Torsteinsdottir S,Masucci MG,Brautbar C,Lenoir G,Klein G,Klein E

    更新日期:1986-04-01 00:00:00

  • The receptor-mediated uptake, survival, replication, and drug sensitivity of Mycobacterium tuberculosis within the macrophage-like cell line THP-1: a comparison with human monocyte-derived macrophages.

    abstract::We have compared the interaction of Mycobacterium tuberculosis with the human macrophage-like cell line THP-1 and with human monocyte-derived macrophages (MDM). The association of M. tuberculosis with THP-1 and MDM was comparable in both the presence and the absence of serum. For both cells, serum-mediated binding was...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1999.1554

    authors: Stokes RW,Doxsee D

    更新日期:1999-10-10 00:00:00

  • Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats.

    abstract::Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic r...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2014.04.004

    authors: Mojani MS,Sarmadi VH,Vellasamy S,Sandrasaigaran P,Rahmat A,Peng LS,Ramasamy R

    更新日期:2014-05-01 00:00:00

  • Characterization of IL-2-induced murine cells which exhibit ADCC activity.

    abstract::The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera. A similarity between these two IL-2...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(88)90180-3

    authors: Eisenthal A,Shiloni E,Rosenberg SA

    更新日期:1988-09-01 00:00:00

  • Transplantation resistance to a murine plasmacytoma lacking MHC determinants.

    abstract::A spontaneously arising murine plasmacytoma, HPC-202, derived from a BALB/c.H-2b congenic mouse that lacks any detectable H-2 determinants on its cell surface is described. However, the expression of H-2 determinants is inducible by interferon-gamma. The H-2 negative cell surface phenotype permits the HPC-202 tumor to...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(90)90114-7

    authors: Daley MJ,Williams TJ,Giorgi J,Warner NL

    更新日期:1990-04-15 00:00:00

  • Characterization and mechanisms of thymic atrophy in protein-malnourished mice: role of corticosterone.

    abstract::The purpose of this project was to characterize changes in murine T lymphocyte subpopulations during thymic atrophy induced by protein malnutrition and to determine the role of elevated serum corticosterone in this process. A suitable animal model was generated by placing mice on protein-sufficient (PS) and protein-de...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1993.1105

    authors: Barone KS,O'Brien PC,Stevenson JR

    更新日期:1993-04-15 00:00:00

  • Acquisition of functional MHC class II/peptide complexes by T cells during thymic development and CNS-directed pathogenesis.

    abstract::This study provides evidence that both rat and mouse thymic and splenic T cells express significant levels of MHC class II glycoproteins (MHCII) in vivo. Derivation of rat and mouse chimeras revealed that a major source of MHCII on thymic T cells was acquired from radioresistant host APC. Expression of MHC on thymic T...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/s0008-8749(02)00577-4

    authors: Walker MR,Mannie MD

    更新日期:2002-07-01 00:00:00

  • Purification and characterization of two forms of rat interleukin-2.

    abstract::Rat IL-2 produced by spleen cells in culture with concanavalin A was purified using gel filtration, hydrophobic chromatography, and ion-exchange chromatography. At least two forms of rat IL-2 were found to be separable by ion-exchange chromatography. These two forms have been designated form I and form II. Form I of r...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(88)90251-1

    authors: Thompson LP,Di Sabato G

    更新日期:1988-06-01 00:00:00

  • Accessory cell requirements for saponin adjuvant-induced class I MHC antigen-restricted cytotoxic T-lymphocytes.

    abstract::The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1006/cimm.1994.1086

    authors: Wu JY,Gardner BH,Kushner NN,Pozzi LA,Kensil CR,Cloutier PA,Coughlin RT,Newman MJ

    更新日期:1994-04-01 00:00:00

  • Rapid response to Con A by CD4+CD45R- rat memory lymphocytes as compared to CD4+CD45R+ lymphocytes.

    abstract::Functionally distinct subpopulations within the CD4+ subset of T lymphocytes have been described in man, rat, and mouse. In the rat different functions have been assigned to CD45R+ and CD45R- T helper cells. The CD45R+ in contrast to the CD45R- T helper cells have been reported to produce IL-2 and to proliferate well ...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(89)90247-5

    authors: Hedlund G,Dohlsten M,Ericsson PO,Sjögren HO

    更新日期:1989-04-01 00:00:00

  • Studies on phagocytosis of unopsonized rabbit erythrocytes by human monocytes.

    abstract::Monolayers of freshly isolated human monocytes are known to ingest particulate activators of the human alternative complement pathway. The ingestion of rabbit erythrocytes, ER, by human monocytes in serum-free medium was studied. The process is Mg2+-dependent and optimum phagocytic activity was obtained at approximate...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/0008-8749(88)90024-x

    authors: Chakravarti B

    更新日期:1988-05-01 00:00:00

  • Induction of tumor antigen-specific cytotoxic T cell responses in naïve mice by latex microspheres-based artificial antigen-presenting cell constructs.

    abstract::Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2007.07.002

    authors: Shen C,Zhang J,Xia L,Meng F,Xie W

    更新日期:2007-05-01 00:00:00

  • Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response.

    abstract::The objective of this study was to evaluate the potential of transcutaneous immunization with tumor antigen to induce cell-mediated immunity. For this purpose, hydrophilic recombinant gp100 protein (HR-gp100) was topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. We demonstrate th...

    journal_title:Cellular immunology

    pub_type: 杂志文章

    doi:10.1016/j.cellimm.2010.09.003

    authors: Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M

    更新日期:2010-01-01 00:00:00