Androgens alter B cell development in normal male mice.

Abstract:

:Castration of normal male mice leads to splenic enlargement and expansion of the B cell population. Since the spleen does not express receptors for androgens, these changes are most likely mediated by effects of androgens on other target organs. Two potential sites of androgen-mediated effects on B cells are evaluated in these studies: thymus and bone marrow. We first confirmed other findings indicating that castration of normal male mice results in expansion in the numbers of bone marrow B cells and then extended these observations by showing that these changes were reversible following androgen replacement. B cell expansion in castrate marrow and spleen was not altered by prior thymectomy, suggesting that thymic androgen receptors are not involved in the observed effects. Androgen receptors were found to be present in both immature B cells and marrow stromal cells by immunoblotting and ligand binding assays. The results suggest a direct modulatory role for androgens on B cells within the bone marrow compartment.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Viselli SM,Reese KR,Fan J,Kovacs WJ,Olsen NJ

doi

10.1006/cimm.1997.1227

subject

Has Abstract

pub_date

1997-12-15 00:00:00

pages

99-104

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(97)91227-2

journal_volume

182

pub_type

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