Antigenic phenotype of TdT-positive cells in human peripheral blood.

Abstract:

:Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility complex, namely HLA-A,B and Ia-like antigens. A small proportion of TdT+ cells expressed antigens restricted to B lymphocytes and their precursors (BA-1+ CALLA+). In contrast, antigens associated with T-lymphocyte differentiation were not detected using a panel of T-cell-specific monoclonal antibodies. These results preclude the possibility that circulating TdT+ cells are immature cortical thymocytes that have "leaked" into the bloodstream. Although bone marrow-derived prothymocytes, which have not yet acquired T-cell lineage markers, may be included amongst this subset, the expression of B-cell related antigens by some TdT+ cells indicates the likely existence of lineage heterogeneity amongst this population of lymphoid cells. The relevance of these findings to the monitoring of human acute lymphoblastic leukaemia is discussed.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Bradstock KF,Kerr A,Bollum FJ

doi

10.1016/0008-8749(85)90223-0

subject

Has Abstract

pub_date

1985-02-01 00:00:00

pages

590-8

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(85)90223-0

journal_volume

90

pub_type

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