IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2.

abstract：:Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca(2+)-dependent activation pathway. In the present experiments we studied the pr...

journal_title：Cellular immunology

authors： Somodi S,Balajthy A,Szilágyi O,Pethő Z,Harangi M,Paragh G,Panyi G,Hajdu P

更新日期：2013-01-01 00:00:00

abstract：:During normal lymphocyte recirculation and in chronic inflammation, lymphocytes emigrate from blood into the perivascular tissue. The mechanism of lymphocyte migration through the endothelial cell (EC) layer of blood vessels is poorly understood. To identify factors that control lymphocyte emigration, a method has bee...

journal_title：Cellular immunology

authors： Oppenheimer-Marks N,Ziff M

更新日期：1988-07-01 00:00:00

abstract：:Four groups of colostrum-deprived pigs were immunized with Porcilis Glässer® (PG) or with subunit vaccines developed by us (rTbpA, NPAPT(M) or NPAPT(Cp)) against Glässer's disease, and they were challenged with 3×10(8)CFU of Haemophilus parasuis. A strong reduction in CD3(+)γδTCR(+) cells was seen in non-immunized con...

journal_title：Cellular immunology

authors： Frandoloso R,Martínez-Martínez S,Yubero S,Rodríguez-Ferri EF,Gutiérrez-Martín CB

更新日期：2012-05-01 00:00:00

abstract：:To characterize the binding properties of the Fc receptors on human macrophages, the binding of radiolabeled human IgG1 to peritoneal macrophages was assessed. Cells were obtained at the time of diagnostic laparoscopy from women undergoing evaluation of infertility. Macrophages bound on the average more IgG1 monomer t...

journal_title：Cellular immunology

authors： Kurlander RJ,Haney AF,Gartrell J

更新日期：1984-07-01 00:00:00

abstract：:Previously, we reported that human B lymphocytes can be stimulated by trinitrophenylated Brucella abortus (TNP-Ba) in vitro to generate T-independent (TI) hapten specific plaque-forming cells (PFC). Furthermore we showed that addition of Con A on Day 3 of culture enhanced the anti-TNP response. In this report the char...

journal_title：Cellular immunology

authors： Golding B,Rittenberg MB

更新日期：1984-05-01 00:00:00

abstract：:We have previously shown that whole cell preparations of Candida albicans are capable of inducing immunosuppressive B-cell activity both in vivo and in vitro. In an effort to characterize the components of the yeast which manifest this immunomodulatory activity, we have successfully generated a soluble extract with di...

journal_title：Cellular immunology

authors： Cuff CF,Taub DD,Rogers TJ

更新日期：1989-08-01 00:00:00

abstract：:The Interferon-inducible gene IFI16, a member of the HIN200 family, is activated by oxidative stress and cell density, in addition to Interferons, and it is implicated in the regulation of endothelial cell proliferation and vessel formation in vitro. We have previously shown that IFI16 is required for proinflammatory ...

journal_title：Cellular immunology

authors： Sponza S,De Andrea M,Mondini M,Gugliesi F,Gariglio M,Landolfo S

更新日期：2009-01-01 00:00:00

abstract：:Previous work in our laboratory established that individual complement components can be regulated in vivo by administration of specific antibody or immunocompetent cells to newborns and in vitro by administration of specific antibody to cultured peritoneal macrophages or splenic fragments. Antibody-induced suppressio...

journal_title：Cellular immunology

authors： Goldman JN,O'Rourke KS,Goldman MB

更新日期：1985-11-01 00:00:00

abstract：:Acting through CD14 and TLR4/MD-2, lipopolysaccharide (LPS) triggers strong pro-inflammatory activation of macrophages, which, if not appropriately controlled, may lead to lethal septic shock. Therefore, numerous mechanisms of negative regulation of responses to LPS exist, but whether they include down-regulation of L...

journal_title：Cellular immunology

authors： Józefowski S,Śróttek M

更新日期：2017-02-01 00:00:00

abstract：:Cytotoxic T-cell (CTL) cultures were generated from five ovarian cancer patients (OvCTL) and from three breast cancer patients (BrCTL). All CTL lines were T-cell receptor (TcR) alphabeta+ and predominantly CD8+ (73 +/- 13%). These CTL lines preferentially recognized autologous tumor cells in an HLA class I-restricted,...

journal_title：Cellular immunology

authors： Goedegebuure PS,Douville CC,Doherty JM,Linehan DC,Lee KY,Ganguly EK,Eberlein TJ

更新日期：1997-02-01 00:00:00

abstract：:Mice that received a sublethal, intraperitoneal dose of viable Listeria monocytogenes, virulent strain 10403, exhibited a systemic increase in natural killer (NK) activity. The kinetics of the response differed with respect to the various effector cell populations analyzed. Resident peritoneal cells and peripheral blo...

journal_title：Cellular immunology

authors： Kearns RJ,Leu RW

更新日期：1984-04-01 00:00:00

abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...

journal_title：Cellular immunology

authors： Gallily R,Sher T,Ben-Av P,Loewenstein J

更新日期：1989-06-01 00:00:00

abstract：:Arriving at an understanding of the role of suppressor T-cells (regulatory T-cells, CD4(+)CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views share an author. Here the arguments are deta...

journal_title：Cellular immunology

authors： Cohn M

更新日期：2004-02-01 00:00:00

abstract：:This study examines cytotoxic mechanisms used by channel catfish peripheral blood-derived effector cells. Transmission electron microscopy (TEM), coupled with [(3)H]thymidine DNA fragmentation (JAM) and terminal deoxynucleotidyl nick-end labeling (TUNEL) assays, provided the first evidence that catfish peripheral bloo...

journal_title：Cellular immunology

authors： Hogan RJ,Taylor WR,Cuchens MA,Naftel JP,Clem LW,Miller NW,Chinchar VG

更新日期：1999-08-01 00:00:00

abstract：:The phenotype, T-cell antigen receptor (TCR) usage and specificity of intestinal intraepithelial lymphocytes (IEL), and hybridomas derived from IEL have been examined. In young conventionally reared mice, approximately 50% of the IEL express TCR alpha beta and 50% express TCR gamma delta, although there is considerabl...

journal_title：Cellular immunology

authors： Sydora BC,Mixter PF,Houlden B,Hershberg R,Levy R,Comay M,Bluestone J,Kronenberg M

更新日期：1993-12-01 00:00:00

abstract：:Spleen cells from neonatal mice belonging to strains with the I-J-b or I-J-k genotype, were treated with anti-I-Jb or anti-I-Jk antibody and complement. This reduces their suppressor cell activity as demonstrated by a decrease in the ability to suppress the mixed-lymphocyte reactivity of adult spleen cells. Injection ...

journal_title：Cellular immunology

authors： Argyris BF,Waltenbaugh C

更新日期：1983-09-01 00:00:00

abstract：:Chronic allotype suppression was generated in M-1 (C mu), G-1 (C gamma) heterozygous B14 line chickens either by embryonal injection or by maternal transfer of anti-M-1b allotype antibodies. Using a sensitive radioimmunoassay to detect the suppressed IgM-1b, a striking disparity was observed between the degree of supp...

journal_title：Cellular immunology

authors： Ratcliffe MJ

更新日期：1984-01-01 00:00:00

abstract：:Macrophages in varying states of activation differ in their ability to perform antibody-dependent cellular cytotoxicity (ADCC) and antibody-independent macrophage-mediated tumor cytotoxicity (MTC). To define further the activation requirements for macrophages to perform various cytolytic functions, we stimulated pepto...

journal_title：Cellular immunology

authors： Fan S,Fehr HG,Adams D

更新日期：1991-06-01 00:00:00

abstract：:Interleukin (IL)-35 strongly suppresses the immune effects of CD8+ T cells. However, the mechanisms mediating these effects are not clear. Here, we investigated the potential inhibitory mechanisms of IL-35 using proteomics technology. The changes of differentially expressed proteins (DEPs) were evaluated using gene on...

journal_title：Cellular immunology

authors： Li X,Dong Y,Tu K,Wang W

更新日期：2020-02-01 00:00:00

abstract：:Varying the concentration of anti-CD3 immobilized on Sepharose beads allowed us to study both the inhibitory and the stimulatory effects of IL-4 on purified T cells and contrast IL-4 versus IL-2-driven T-cell proliferative responses. In the presence of low density immobilized anti-CD3, IL-4 was unable to stimulate pur...

journal_title：Cellular immunology

authors： Jones-Tiffany LA,Mehrotra PT,Horohov DW,Siegel J,Kozak RW

更新日期：1993-04-01 00:00:00

abstract：:Al adjuvants are used in vaccines to increase the immune response. NTPDase and AChE play a pivotal role and act in the regulation of the immune system. The effect of Al exposure in vitro and in vivo on NTPDase and AChE activities in the lymphocytes of rats was determined. In vitro, ATP hydrolysis was decreased by 20.4...

journal_title：Cellular immunology

authors： Kaizer RR,Gutierres JM,Schmatz R,Spanevello RM,Morsch VM,Schetinger MR,Rocha JB

更新日期：2010-01-01 00:00:00

abstract：:We have investigated the ability of long-term cultured T helper (Th) cell lines to help an in vivo cytotoxic T lymphocyte (CTL) response to non-H-2 alloantigens (minor antigens). Th cell lines specific for various single or undefined minor antigens were selected by regular restimulation with antigen in vitro. They wer...

journal_title：Cellular immunology

authors： Gascoigne NR,Lai PK

更新日期：1984-02-01 00:00:00

abstract：:The biological response modifier OK-432 has been shown both to exert the enhancement of several immunological activities and to have a direct anti-tumor effect. The present study examines the immunopotentiating effect of OK-432 on peripheral blood monocytes (PBM) derived from normal humans. Monocyte activation was ass...

journal_title：Cellular immunology

authors： Bonavida B,Jewett A

更新日期：1989-10-15 00:00:00

abstract：:IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD)...

journal_title：Cellular immunology

authors： Wu CA,Peluso JJ,Zhu L,Lingenheld EG,Walker ST,Puddington L

更新日期：2010-01-01 00:00:00

abstract：:To investigate the process of tolerance induction we have developed an in vivo model using TCR beta-chain transgenic mice tolerized with the superantigen staphylococcal enterotoxin B. We have previously demonstrated that tolerized peripheral T cells were anergic when stimulated in vitro with immunogenic peptides, supe...

journal_title：Cellular immunology

authors： Perkins DL,Listman JA,Wang Y,Ho SS,Finn PW,Rimm IJ

更新日期：1994-07-01 00:00:00

abstract：:It has long been believed that mast cells play a crucial role in the development of many physiological changes during immediate allergic responses. This study was conducted to evaluate the anti-inflammation mechanism of Schizonepeta tenuifolia (ST) extract and ST purified chemicals on the PMA plus A23187-induced stimu...

journal_title：Cellular immunology

authors： Sohn SH,Cho S,Ji ES,Kim SH,Shin M,Hong M,Bae H

更新日期：2012-05-01 00:00:00

abstract：:Agents that extract or sequester membrane cholesterol stimulate IkappaB degradation and lead to NF-kappaB activation in a subset of B cells. Although the extraction of cholesterol by methyl-beta-cyclodextrin is the most potent stimulus of NF-kappaB, other agents that sequester cholesterol have similar effects. B cells...

journal_title：Cellular immunology

authors： Flemming JA,Perkins KH,Luus L,Ferguson AR,Corley RB

更新日期：2004-05-01 00:00:00

abstract：:The transfer of B cells from mice immunized with Type III pneumococcal polysaccharide (SSS-III) results in the activation of suppressor and amplifier T cells that control the magnitude of the antibody response in recipient mice, immunized subsequently with SSS-III. Prior treatment of transferred B cells with an excess...

journal_title：Cellular immunology

authors： Baker PJ,Taylor C,Fauntleroy MB,Stashak PW,Prescott B

更新日期：1985-12-01 00:00:00

abstract：:To clarify the role of B cells in the establishment of T cell response against intracellular bacteria, B-cell-deficient (muMT-/-) mice were infected with an intracellular bacteria, Listeria monocytogenes, and T cell response against the bacteria was analyzed. On day 6 of primary Listeria infection, spleen T cells of t...

journal_title：Cellular immunology

authors： Matsuzaki G,Vordermeier HM,Hashimoto A,Nomoto K,Ivanyi J

更新日期：1999-06-15 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is the etiological agent most frequently associated with bacterial exacerbations of chronic obstructive pulmonary disease (COPD). The present work shows that NTHi strains induced in primary normal human bronchial epithelial cells (NHBE) a cytokine/chemokine response in which C...

journal_title：Cellular immunology

authors： Teng F,Slavik V,Duffy KE,San Mateo L,Goldschmidt R

更新日期：2010-01-01 00:00:00