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Toll-like receptor 3 is involved in airway epithelial cell response to nontypeable Haemophilus influenzae.

Abstract：

:Nontypeable Haemophilus influenzae (NTHi) is the etiological agent most frequently associated with bacterial exacerbations of chronic obstructive pulmonary disease (COPD). The present work shows that NTHi strains induced in primary normal human bronchial epithelial cells (NHBE) a cytokine/chemokine response in which CCL-5 and CXCL-10 were predominant. Production of both cytokines was inhibited by an anti-TLR3 monoclonal antibody (mAb) in a dose-dependent manner, but not by control human IgG4 antibodies, thus suggesting a TLR3-dependency of the NTHi stimulation. BEAS-2B, an immortalized human bronchial epithelial cell line, also showed a similar NTHi-induced response that was inhibited by the anti-TLR3 mAb. A BEAS-2B cell line stably expressing TLR3 siRNA showed significantly reduced cytokine/chemokine responses to NTHi stimulation, confirming the role of TLR3 in the response. These results indicate that TLR3 is a key component in the response of human bronchial epithelial cells to NTHi, and suggest that cognate neutralizing mAbs might be a useful therapeutic tool to regulate the inflammatory response.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Teng F,Slavik V,Duffy KE,San Mateo L,Goldschmidt R

doi

10.1016/j.cellimm.2009.09.008

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

98-104

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(09)00165-8

journal_volume

260

pub_type

杂志文章

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