Abstract:
:Immune responses to non-pathogenic yeasts induced within the draining lymph node remain to be understood. In this study, we have investigated the changes in lymphocytes and their activity in skin-draining lymph nodes in response to transdermally injected zymosan (component of the yeast cell wall). Zymosan elicited the transient increase of B cell number and activation status without affecting the capacity for proliferation. The increased B cell content in the regional lymph nodes was likely due to the reduction of B cell egress from the tissue and in part the increase of homing from the circulation. Zymosan also upregulated the inflammatory cytokines, such as IL-1β, IL-6, IL-12, and IFNγ, regulatory cytokines IL-10 and TGFβ, and lymphoid chemokine CXCL13. Among these, the expression of IL-12 and IL-10 was markedly high in B cells. Altogether, these findings demonstrate a unique B cell-associated response to non-pathogenic yeast component in the draining lymph nodes. This will provide insights into the clinical and healthcare applications of non-pathogenic beneficial microbes.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Rahman MA,Kanda Y,Ozawa M,Kawamura T,Takeuchi A,Katakai Tdoi
10.1016/j.cellimm.2020.104159subject
Has Abstractpub_date
2020-09-01 00:00:00pages
104159eissn
0008-8749issn
1090-2163pii
S0008-8749(20)30319-1journal_volume
355pub_type
杂志文章abstract::Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expre...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2004.04.004
更新日期:2004-04-01 00:00:00
abstract::The experiments in this manuscript confirm and extend our previous finding that IL4 has minimal enhancing activity on B cell activation stimulated by anti-Ig-dextran conjugates. The absence of significant IL4-mediated enhancement is seen also under conditions which are limiting for optimal B cell proliferation. Thus, ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90275-v
更新日期:1990-10-15 00:00:00
abstract::Serum of an autoimmune MRL/Mp-lpr/lpr (MRL/l) mouse supported the proliferation of interleukin 3 (IL-3)-dependent cell line, FDC-P2. This IL-3-like activity initially appeared at 1 month of age and increased with age. Females showed higher titers than did males. MRL/Mp-+/+ mouse sera also exhibited such activity, thou...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90030-0
更新日期:1989-07-01 00:00:00
abstract::Interleukin 4 (IL-4)-induced IgE production by normal peripheral blood mononuclear cells (PBMC) and E- cells (PBMC partially depleted of T cells) was significantly enhanced by leukotriene B4(LTB4) in a dose-dependent manner, whereas LTB4 by itself was not effective for IgE production. The potentiating effect of LTB4 w...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1158
更新日期:1994-06-01 00:00:00
abstract::Thirty-two cord blood samples taken after caesarean section or vaginal delivery and concurrent venous blood samples obtained from normal adult controls were evaluated using monoclonal antibodies. The percentage of circulating pan-T-cell+ lymphocytes was significantly lower in cord blood (46%) compared with adult contr...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90069-3
更新日期:1985-04-15 00:00:00
abstract::Treatment with bacterial lipopolysaccharide elicits the appearance of greater numbers of background antigen-specific plaque-forming cells (PFC) in the spleens of mice previously exposed or primed to subimmunogenic amounts of various non-cross-reacting antigens so as to generate detectable immunological memory. These f...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90235-8
更新日期:1987-07-01 00:00:00
abstract::NK and extrathymic T cells are abundant in the decidua of the pregnant uterus. To determine how this unique pattern is induced, overall populations of leukocytes were examined in the blood and other tissues in pregnant women. Time-kinetic studies showed that a basal change of leukocytes during pregnancy was granulocyt...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1541
更新日期:1999-08-25 00:00:00
abstract::CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic HIV-1 strains to enter the host cells. In this study, we aim to better understand the ligand-binding profiles of CCR5 and the chemokine-receptor usage on leukocyte cells. We fou...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1379
更新日期:1998-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90198-z
更新日期:1990-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2018.11.008
更新日期:2019-01-01 00:00:00
abstract::In the mouse, activation of T cells by T cell receptor (TCR) crosslinking with anti-CD3 antibodies in the absence of a costimulatory signal induces Th1 but not Th2 cell anergy. Furthermore, anti-CD3 induces anergy of Th1- but not Th2-type lymphokine secretion in Th0 cells. This study was designed to determine whether ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1199
更新日期:1995-10-01 00:00:00
abstract::We showed previously that the expressions of various src family protein tyrosine kinases (PTKs) were induced independently during the monocytic differentiation of HL-60 cells. The role of PTKs was further assessed in the present study by investigating the effects of PTK inhibitors on the differentiation. It was demons...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(92)90196-v
更新日期:1992-04-01 00:00:00
abstract::Previous studies have shown that the anti-CD4 mAb W3/25 strongly enhances T cell APC (T-APC) activity. In this study, single positive CD4+ and double negative (DN) (CD4-CD8-) T-helper cells specific for the 55-69 or 72-86 sequence of guinea pig (GP) myelin basic protein (GPMBP) were used to study CD4 regulation of T-A...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1299
更新日期:1998-06-15 00:00:00
abstract::TNF-alpha plays an important role in the development of secondary lymphoid tissues. Earlier studies showed that fibroblastic reticular cells express TNF-alpha receptor, suggesting that TNF-alpha may affect the development of FRCs. To test this, we analyzed the development and function of FRCs in wild-type or TNF-alpha...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2015.01.006
更新日期:2015-02-01 00:00:00
abstract::A previous report (G. E. Woloschak and D. Senitzer, submitted for publication) has demonstrated that mitogen-stimulated splenocytes fuse at a much higher frequency than untreated splenocytes as measured by the fusion index (a calculation of the number of nuclei in fused cells vs the total number of nuclei). A measurem...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(83)90059-x
更新日期:1983-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0071
更新日期:1996-03-15 00:00:00
abstract::The internalization of surface immunoglobulin (Ig) by B lymphocytes is the first step in the antigen-presenting function performed by these cells. Mature B cells coexpress on their surface IgM and IgD. At this time, there is controversy over whether these two isotypes serve different functions in the antigen-presentin...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90305-5
更新日期:1989-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2013.04.013
更新日期:2013-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.2000.1737
更新日期:2001-01-10 00:00:00
abstract::It has previously been demonstrated that within 6 hr after immunogenic stimulation the serum of mice contains a unique form of immunogenic antigen which represents complexes of Ig and antigen. The complexes are known to be strongly cytophilic for Ly2+ Ia+ FcR+ T cells and markedly enhance the IgG response. Anti-I-A tr...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90064-4
更新日期:1985-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90091-1
更新日期:1984-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2018.12.009
更新日期:2019-02-01 00:00:00
abstract::Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0086
更新日期:1996-04-10 00:00:00
abstract::We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recogniz...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90079-7
更新日期:1990-01-01 00:00:00
abstract::IgA nephropathy (IgAN) is a tonsil-related disease. We previously showed that oligodeoxynucleotides with CpG (CpG-ODN) and B-cell activation factor (BAFF) are involved in hyperproduction of IgA from tonsillar mononuclear cells of patients with IgAN (IgAN-TMCs). In this study, we focused on a proliferation-inducing lig...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2019.103925
更新日期:2019-07-01 00:00:00
abstract::Bcl-2 proto-oncogene is expressed in normal lymphoid tissues and its role has been suggested to involve the selection of B and T cells. Here we report three-color flow cytometric studies on the expression of bcl-2 protein in the thymus and periphery. Bcl-2 was expressed in the majority of T and B cells and down-regula...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1127
更新日期:1994-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2013.01.006
更新日期:2013-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1581
更新日期:1999-11-25 00:00:00
abstract::Nickel (Ni) can cause delayed-type hypersensitivity reactions, which are thought to be mediated by the accumulation of T cells into inflamed skin. Accumulated T cells at the developmental stages in metal allergy are poorly characterized because a suitable animal model has not been established. To investigate the accum...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2013.07.010
更新日期:2013-07-01 00:00:00
abstract::Participation of IE antigens (Ag) in immune response as the transplantation Ag was examined. IE- B10.A(4R)(4R; Kk, IAk, IE-, Db) mice could not reject skin graft from IE Ag alone-disparate B10.A(2R) (2R; Kk, IAk, IEk, Db) mice despite intravenous (iv) injection of 2R spleen cells (SC) before or after skin grafting, in...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(92)90037-p
更新日期:1992-09-01 00:00:00