Abstract:
:We showed previously that the expressions of various src family protein tyrosine kinases (PTKs) were induced independently during the monocytic differentiation of HL-60 cells. The role of PTKs was further assessed in the present study by investigating the effects of PTK inhibitors on the differentiation. It was demonstrated that PTK inhibitors such as genistein and herbimycin A modulated monocytic differentiation of HL-60 cells; they inhibited the differentiation induced by TPA, while promoting that induced by vitamin D3 (D3). Immunoblotting analysis of protein molecules which had been phosphorylated on their tyrosine residues demonstrated that TPA induced phosphorylation of certain molecules different from those induced by D3 in HL-60 cells. PTK inhibitors blocked the phosphorylation and modulated differentiation driven by the inducers. These data suggest that PTKs are involved both promotively and suppressively in signaling events that induce monocytic differentiation of HL-60 cells.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Katagiri K,Katagiri T,Kajiyama K,Uehara Y,Yamamoto T,Yoshida Tdoi
10.1016/0008-8749(92)90196-vsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
282-94issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(92)90196-Vjournal_volume
140pub_type
杂志文章abstract::Many studies have shown that tumor necrosis factor (TNF) is a potent soluble mediator of immunoregulation and inflammation. Neuropeptide substance P (SP) has been known to exert significant influence on production of certain inflammatory cytokine by immune cells. Immunopathogenic mechanism underlying the effect of neu...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.9969
更新日期:1995-12-01 00:00:00
abstract::Dexamethasone is a potent anti-inflammatory and immunosupressive agent that has complex, yet incompletely defined, effects on the immune response. Here, we explored the effect of dexamethasone on the expression of TCR zeta chain and TCR/CD3-induced early signaling events in human T lymphocytes. Immunoblotting studies ...
journal_title:Cellular immunology
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更新日期:2003-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1264
更新日期:1998-02-25 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(83)90214-9
更新日期:1983-10-01 00:00:00
abstract::Activin A is a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily and acts as an anti-inflammatory cytokine produced by microglia and macrophages. In this study, we investigated the regulatory effect and possible mechanism of activin A on activation of lipopolysaccharide (LPS)-induced...
journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
abstract::Phagocytosis of pathogens by macrophages is crucial for the successful resolution of inflammation induced by microbial infection. Taurine chloramine (TauCl), an endogenous anti-inflammatory and antioxidative substance, is produced by reaction between taurine and hypochlorous acid by myeloperoxidase activity in neutrop...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2018.02.003
更新日期:2018-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(87)90083-9
更新日期:1987-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(83)90060-6
更新日期:1983-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2010.03.012
更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2011.06.003
更新日期:2011-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90108-6
更新日期:1988-02-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2007.05.005
更新日期:2007-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0242
更新日期:1996-09-15 00:00:00
abstract::The phenotypic and functional relationships among the various B-cell subsets is of importance for better understanding studies of the immune system. In this report, the realm of B cells encompassed by Lyb 5, Ly 1, and xid has been examined through the use of the alloantiserum anti-Lyb 5, the unique functional properti...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90077-2
更新日期:1985-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2016.07.004
更新日期:2016-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(91)90180-j
更新日期:1991-03-01 00:00:00
abstract::The mechanism of human peripheral blood monocyte-mediated cytotoxicity was investigated using the HT-29 human colon adenocarcinoma line, A673 human rhabdomyosarcoma line, and A375 human melanoma line as target cells. Pretreatment of these target cells with 100 U/ml of recombinant human interferon (IFN)-gamma for 48 hr...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90236-4
更新日期:1986-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90195-5
更新日期:1988-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.03.003
更新日期:2008-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2017.06.003
更新日期:2017-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/s0008-8749(02)00018-7
更新日期:2002-02-01 00:00:00
abstract::A previous report (G. E. Woloschak and D. Senitzer, submitted for publication) has demonstrated that mitogen-stimulated splenocytes fuse at a much higher frequency than untreated splenocytes as measured by the fusion index (a calculation of the number of nuclei in fused cells vs the total number of nuclei). A measurem...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(83)90059-x
更新日期:1983-07-01 00:00:00
abstract::The effect of the addition of dialyzable leukocyte extract (DLE)(transfer factor) to tuberculostatic drugs in the treatment of superinfected fistulating tuberculosis of bones and joints was evaluated in a controlled study. Eleven patients whose disease had persisted for a mean of 20 +/- 4.8 years and had proved to be ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90091-1
更新日期:1984-03-01 00:00:00
abstract::We recently reported that a cloned murine cell line with "natural killer (NK)-like" cytolytic function and prominent cytoplasmic granules also expressed large numbers of plasma membrane receptors (Fc epsilon R) which bound mouse immunoglobulin E (IgE) with high affinity (S.J. Galli et al., 1982, Nature (London) 298, 2...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90353-3
更新日期:1985-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90158-3
更新日期:1985-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.06.001
更新日期:2008-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1439
更新日期:1999-03-15 00:00:00
abstract::The lineage of lymphokine-activated killer (LAK) cells is poorly understood. To examine the relationship between LAK and natural killer (NK) cells we utilized two congenitally immunodeficient mice, namely severe combined immunodeficient (scid) and athymic (nude) mice that lack T cells but have normal NK cells. LAK act...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90190-1
更新日期:1989-04-15 00:00:00