Divergent effects of cyclosporine A on interferon- and mitogen-induced Ly-6A antigen suggest autocrine regulation of Ly-6A expression in activated T cells.

abstract：:Purine nucleoside phosphorylase (PNP) is a purine salvage pathway enzyme which we have found to be 8-10 times more active (per cell) in human peripheral blood null lymphocytes than in T lymphocytes. To test the hypothesis that null cells are, in part, pre-T lymphocytes we have defined an in vitro system for null cell ...

journal_title：Cellular immunology

authors： Cowan MJ,Fraga M,Ammann AJ

更新日期：1983-06-01 00:00:00

abstract：:The nonspecific suppression of immunological responses that is generated within host popliteal lymph nodes upon exposure to syngeneic normal spleen cells has been examined. The suppression, which had previously been described as being capable of preventing initiation of cytotoxic T lymphocytes (CTLs) to hapten-altered...

journal_title：Cellular immunology

authors： Emara M,Battisto JR

更新日期：1987-03-01 00:00:00

abstract：:We previously demonstrated that injection of a high dose (4 X 10(9] of sheep erythrocytes (SRBC) into C57BL/6 mice results in the generation of splenic B cells (plastic nonadherent, Thy-1- and Ig+) which, when transferred to normal syngeneic recipients, subsequently induce antigen-specific suppressor T cells to suppre...

journal_title：Cellular immunology

authors： Shimamura T,Habu S,Hashimoto K,Sasaki S

更新日期：1984-01-01 00:00:00

abstract：:The programmed death (PD)-1/PD-1 ligands (PD-Ls) pathway, is a new member of the B7/CD28 family, and consists of the PD-1 receptor and its ligands PD-L1 (B7-H1, CD274) and PD-L2 (B7-DC, CD273). Recently, it is reported that PD-1, PD-L1 and PD-L2 also have soluble forms aside from their membrane bound forms. The solubl...

journal_title：Cellular immunology

authors： Dai S,Jia R,Zhang X,Fang Q,Huang L

更新日期：2014-07-01 00:00:00

abstract：:Like the thymus, the bursa of Fabricius is a site of massive lymphopoiesis accompanied by cell death in vivo. In the present study we have, therefore, examined whether chicken bursa and thymus cells exhibit apoptosis. Bursa and thymus cells from SC chickens, 4-10 weeks of age, were incubated for 8-24 hr with various r...

journal_title：Cellular immunology

authors： Asakawa J,Tsiagbe VK,Thorbecke GJ

更新日期：1993-03-01 00:00:00

abstract：:In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...

journal_title：Cellular immunology

authors： Leghmari K,Contreras X,Moureau C,Bahraoui E

更新日期：2008-01-01 00:00:00

abstract：:Following interaction of the random polymer (Glu60,Phe40)n (GPhe) with antigen-presenting accessory cells (APC), unusual costimulatory activities were noted in several murine T cell systems. When GPhe, in contrast with other random copolymers (GT,GL), was added during "inhibition" and T cell "repertoire" studies as a ...

journal_title：Cellular immunology

authors： Liu DC,Grun JL,Maurer PH

更新日期：1990-08-01 00:00:00

abstract：:The adoptive transfer of tumor-reactive T lymphocytes has recently been demonstrated to be an effective means for mediating the regression of experimental intracranial fibrosarcomas. In this study, mice bearing syngeneic intracranial GL261 gliomas were cured by the combination of sublethal whole body irradiation follo...

journal_title：Cellular immunology

authors： Plautz GE,Touhalisky JE,Shu S

更新日期：1997-06-15 00:00:00

abstract：:Aging induces a number of changes in the immune system, including the involution of the thymus which results in the loss of thymic hormone production and alteration in T cell function. One age-dependent change in immune response is the increasing risk of developing acute or chronic form of graft-versus-host disease (G...

journal_title：Cellular immunology

authors： Fast LD,Kouttab NM,Badamchian M,Goldstein AL

更新日期：1990-11-01 00:00:00

abstract：:One of the auto-antigens aberrantly targeted in Multiple sclerosis is myelin basic protein (MBP). In this study, chronic progressive multiple sclerosis (CPMS) patients receiving the experimental drug MBP8298, on a compassionate care trial, were examined before and after high dose peptide treatment for their circulatin...

journal_title：Cellular immunology

authors： Loo EW,Krantz MJ,Agrawal B

更新日期：2012-11-01 00:00:00

abstract：:A fibroblastoid cell line TSt-4 was established from fetal thymus tissue of C57BL/6 mice. When fetal thymus (FT) cells or CD4-8- (DN) cells of adult thymuses were cultured on the monolayer of TSt-4, a considerable proportion of lymphocytes expressed CD4 or both CD4 and CD8 within 1 day, and the CD4+CD8- cells were mai...

journal_title：Cellular immunology

authors： Watanabe Y,Mazda O,Aiba Y,Iwai K,Gyotoku J,Ideyama S,Miyazaki J,Katsura Y

更新日期：1992-07-01 00:00:00

abstract：:Our previous studies show that growth hormone overexpression (GHo) upregulates the expression of the IGF-1R and IGF-2R resulting in the protection of the EL4 lymphoma cell line from apoptosis. In this study, we report that GHo also increases TGF-beta1 protein expression measured by luciferase promoter assay, Western a...

journal_title：Cellular immunology

authors： Farmer JT,Weigent DA

更新日期：2006-03-01 00:00:00

abstract：:The lineage of lymphokine-activated killer (LAK) cells is poorly understood. To examine the relationship between LAK and natural killer (NK) cells we utilized two congenitally immunodeficient mice, namely severe combined immunodeficient (scid) and athymic (nude) mice that lack T cells but have normal NK cells. LAK act...

journal_title：Cellular immunology

authors： Hasui M,Saikawa Y,Miura M,Takano N,Ueno Y,Yachie A,Miyawaki T,Taniguchi N

更新日期：1989-04-15 00:00:00

abstract：:We have addressed the differential regulatory properties that IFN-gamma and IL-4 exert on macrophage (M phi) subpopulations. For this purpose, Thyoglicolate-, Peptone-, and Con A-elicited M phi, as well as bone marrow-derived M phi and P388D1 cells, were cultured in the presence of either IFN-gamma or IL-4. The expres...

journal_title：Cellular immunology

authors： Molina IJ,Huber BT

更新日期：1991-04-15 00:00:00

abstract：:Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptibl...

journal_title：Cellular immunology

authors： Speziali E,Santiago AF,Fernandes RM,Vaz NM,Menezes JS,Faria AM

更新日期：2009-01-01 00:00:00

abstract：:Polymorphonuclear cell (PMN) transmigration across the TNF-alpha-stimulated endothelial cell (HUVEC) monolayer in the presence of shear flow was monitored with time-lapse videotapes. More than half of the PMN that arrested on HUVEC transmigrated through endothelial cell junctions within the following 15 min. The kinet...

journal_title：Cellular immunology

authors： Kitayama J,Hidemura A,Saito H,Nagawa H

更新日期：2000-07-10 00:00:00

abstract：:Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expre...

journal_title：Cellular immunology

authors： Leid JG,Jutila MA

更新日期：2004-04-01 00:00:00

abstract：:Activation of lck-fyn kinases during T cell receptor signaling leads to Vav phosphorylation, activation of downstream targets including Rac1, and a transient decline in ezrin and moesin phosphorylation. We have shown that age increases Rac1 activity and lowers ezrin and moesin phosphorylation in resting mouse CD4 cell...

journal_title：Cellular immunology

authors： Garcia GG,Miller RA

更新日期：2009-01-01 00:00:00

abstract：:Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...

journal_title：Cellular immunology

authors： Swisher SG,Economou JS,Holmes EC,Golub SH

更新日期：1990-07-01 00:00:00

abstract：:Twenty-seven different CD45 monoclonal antibodies (mAb) were assessed for their ability to block cytotoxicity of alloreactive CD4+ MHC class II-specific or CD8+ class I-specific human T cell clones (n = 3 and 5, respectively). Twelve of 27 blocked the former but only 1/27 the latter, although all 27 significantly inhi...

journal_title：Cellular immunology

authors： Pawelec G,Bühring HJ,Müller C

更新日期：1990-05-01 00:00:00

abstract：:Previously, we reported that human B lymphocytes can be stimulated by trinitrophenylated Brucella abortus (TNP-Ba) in vitro to generate T-independent (TI) hapten specific plaque-forming cells (PFC). Furthermore we showed that addition of Con A on Day 3 of culture enhanced the anti-TNP response. In this report the char...

journal_title：Cellular immunology

authors： Golding B,Rittenberg MB

更新日期：1984-05-01 00:00:00

abstract：:We have examined noninduced cytotoxicity of mouse gut associated and peripheral lymphoid tissues for a wide variety of syngeneic as well as allogeneic cell lines and lymphoblasts. Lymphoid cells from Peyer's patches were found to lyse these targets in a 3-hr chromium release assay whereas lymphoid cells from intestina...

journal_title：Cellular immunology

authors： Gautam SC,Beckman K,Battisto JR

更新日期：1986-09-01 00:00:00

abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

journal_title：Cellular immunology

authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

更新日期：1995-05-01 00:00:00

abstract：:C3H/HeJ mice are homozygous for the Lpsd allele and, as a consequence, are hyporesponsive to all of the biological effects of bacterial lipopolysaccharide (LPS) that have been studied. These mice die in the early phase of infection when inoculated with virulent Salmonella. This susceptibility is also regulated by the ...

journal_title：Cellular immunology

authors： Weinstein DL,Lissner CR,Swanson RN,O'Brien AD

更新日期：1986-10-01 00:00:00

abstract：:The reactivity of human cord blood lymphocytes was assessed against a panel of monoclonal antibodies (MoAb). The mean proportion of OKT3+ cells (pan-T) was significantly lower in cord blood (52 +/- 13.8%; mean +/- SD) compared with that of adult blood (75 +/- 8.9%) and paralleled well with the E-rosette-forming capaci...

journal_title：Cellular immunology

authors： Foa R,Giubellino MC,Fierro MT,Lusso P,Ferrando ML

更新日期：1984-11-01 00:00:00

abstract：:Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca(2+)-dependent activation pathway. In the present experiments we studied the pr...

journal_title：Cellular immunology

authors： Somodi S,Balajthy A,Szilágyi O,Pethő Z,Harangi M,Paragh G,Panyi G,Hajdu P

更新日期：2013-01-01 00:00:00

abstract：:An Affymetrix mouse genome array and differential in-gel electrophoresis (DIGE) techniques were used to investigate the pharmacological mechanisms of a mixture of herbs, designated CTCM, a compound of traditional Chinese medicine, for the treatment of increased permeability in mouse intestinal microvascular endothelia...

journal_title：Cellular immunology

authors： Yi P,Guo Y,Wang X,Mu X,Wei X

更新日期：2010-01-01 00:00:00

abstract：:Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to...

journal_title：Cellular immunology

authors： Halperin D,Reuben C,Ben-Efraim S,Grover N,Weiss DW

更新日期：1985-05-01 00:00:00

abstract：:Simultaneous stimulation of human monocytes/macrophages or THP1 cells with LPS and an antibody specific for the activation marker CD69 induces apoptosis. Here we demonstrate the involvement of multiple independent signals that are necessary for apoptosis induction. Thus, inhibitors of phospholipase A2 and lipoxygenase...

journal_title：Cellular immunology

authors： Ramírez R,Carracedo J,Castedo M,Zamzami N,Kroemer G

更新日期：1996-09-15 00:00:00

abstract：:The primary objective of this study was to determine whether the n-3 PUFA-mediated changes in host response to a Listeria monocytogenes infection (e.g., cytokine production and bacterial clearance) were dependent upon neutrophils. Balb/c mice were fed one of two semi-purified diets that contained either 0 or 41 g of n...

journal_title：Cellular immunology

authors： Fritsche K,Irons R,Pompos L,Janes J,Zheng Z,Brown C

更新日期：2005-05-01 00:00:00