Involvement of CD45 in MHC class II-allospecific cytotoxicity.

abstract：:We have studied the antibody-induced effect of cross-linking the major histocompatibility complex class I (MHC-I) in human T leukemic cells (Jurkat) and human B lymphoma cells (Solubo, Burkitts lymphoma) on intracellular [Ca2+]i levels. The increase in [Ca2+]i after MHC-I cross-linking in Jurkat cells and Solubo cells...

journal_title：Cellular immunology

authors： Pedersen AE,Jacoby BF,Skov S,Claesson MH

更新日期：1996-11-01 00:00:00

abstract：:The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera. A similarity between these two IL-2...

journal_title：Cellular immunology

authors： Eisenthal A,Shiloni E,Rosenberg SA

更新日期：1988-09-01 00:00:00

abstract：:Homozygosity for either the lpr (lymphoproliferation) or the gld (generalized lymphoproliferative disease) mutation in mice causes the development of strikingly similar hyperglobulinemia and lymphoproliferative syndromes. Nevertheless, previous studies of various C57BL/6 chimeras obtained by reconstitution of irradiat...

journal_title：Cellular immunology

authors： Velin D,Goettelfinger P,Froidevaux S,Loor F

更新日期：1993-05-01 00:00:00

abstract：:Apolipoprotein E (apoE), a lipid transport protein important in cholesterol homeostasis, inhibits the proliferation of interleukin-dependent lymphocytes. Growth factor-responsive cells are blocked in the G1A phase of the cell cycle. Suppression by apoE is independent of growth factor, as evidenced by the fact that int...

journal_title：Cellular immunology

authors： Mistry MJ,Clay MA,Kelly ME,Steiner MA,Harmony JA

更新日期：1995-01-01 00:00:00

abstract：:Interleukin (IL)-35 strongly suppresses the immune effects of CD8+ T cells. However, the mechanisms mediating these effects are not clear. Here, we investigated the potential inhibitory mechanisms of IL-35 using proteomics technology. The changes of differentially expressed proteins (DEPs) were evaluated using gene on...

journal_title：Cellular immunology

authors： Li X,Dong Y,Tu K,Wang W

更新日期：2020-02-01 00:00:00

abstract：:Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronically intestinal autoimmune disease, the pathological mechanisms of which are not very clear. Wild type p-53 induced phosphatase 1 (Wip1), a serine/threonine protein phosphatase, has been reported to negatively reg...

journal_title：Cellular immunology

authors： Zhang Q,Zhang C,Chang F,Liang K,Yin X,Li X,Zhao K,Niu Q,Tian Z

更新日期：2016-12-01 00:00:00

abstract：:We and other investigators have previously demonstrated that mycoplasmas induce macrophage-mediated lysis of tumor cells, but the mechanism responsible for this process had, thus far, not been clarified. We now report that addition of either viable or heat-killed Mycoplasma orale to murine macrophages induces a cytoly...

journal_title：Cellular immunology

authors： Gallily R,Sher T,Ben-Av P,Loewenstein J

更新日期：1989-06-01 00:00:00

abstract：:The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearanc...

journal_title：Cellular immunology

authors： Heeg K,Steeg C,Wagner H

更新日期：1988-01-01 00:00:00

abstract：:Intercellular adhesion molecule (ICAM)-1, or CD54, is a member of the immunoglobulin superfamily that binds to lymphocyte function-associated antigen-1 and macrophage-1 antigen. ICAM-1:LFA-1/Mac-1 interaction may be involved in both activation and extravasation of leukocytes. To determine the roles of ICAM-1 in the de...

journal_title：Cellular immunology

authors： Samoilova EB,Horton JL,Chen Y

更新日期：1998-11-25 00:00:00

abstract：:We analyzed the effect of adherent cells on the induction of lymphokine-activated killer (LAK) cell activity by depleting adherent cells from peripheral blood lymphocytes (PBL) or by adding adherent cells to PBL before culture with interleukin-2. We found that adherent cells clearly down-regulate LAK cell induction. T...

journal_title：Cellular immunology

authors： Ibayashi Y,Hoon DS,Golub SH

更新日期：1987-12-01 00:00:00

abstract：:In vivo treatment with anti-IA antibodies has been shown to induce a haplotype-specific inhibition of EAE when the disease was following passive transfer of MBP-sensitized T cells. In order to determine the mechanism by which anti-IA antibody prevents passively transferred EAE, the homing of radiolabeled cells to the ...

journal_title：Cellular immunology

authors： Sriram S,Carroll L

更新日期：1991-06-01 00:00:00

abstract：:The complement receptor 2 (CR2; CD21), a 145,000 MW glycoprotein, has been useful as a marker of B lymphocyte maturation. It is expressed on the 1:13 monoclonal, EBV-transformed, B cell line which produces TNP-specific IgM-kappa and displays an in vitro capacity for differentiation. The line expresses the CD20+CD21+ p...

journal_title：Cellular immunology

authors： Pillemer SR,Tsokos GC,Barbieri SA,Balow JE,Golding B

更新日期：1990-02-01 00:00:00

abstract：:Supplementation of the diet with fish oil (FO) decreases growth of the Walker 256 tumor and decreases the cachexia associated with tumor-bearing. The mechanisms by which FO inhibits tumor growth and cachexia are unknown. Macrophages are very important in host defence against tumors since they produce several anti-tumo...

journal_title：Cellular immunology

authors： Bonatto SJ,Folador A,Aikawa J,Yamazaki RK,Pizatto N,Oliveira HH,Vecchi R,Curi R,Calder PC,Fernandes LC

更新日期：2004-09-01 00:00:00

abstract：:Interleukins play a role in the process of T-cell development and, like other cytokines, seem able to modulate apoptosis. Interleukin-2 has been reported to inhibit apoptotic cell death of thymocytes induced in vitro by either activation of CD3/TCR complex or treatment with glucocorticoid hormone. We demonstrate here ...

journal_title：Cellular immunology

authors： Migliorati G,Nicoletti I,Pagliacci MC,D'Adamio L,Riccardi C

更新日期：1993-01-01 00:00:00

abstract：:Peripheral blood polymorphonuclear neutrophils (PMN) from mice immunized with Blastomyces dermatitidis and then stimulated locally (intraperitoneally, ip) with B. dermatitidis antigen had enhanced killing of B. dermatitidis in vitro (54.4 +/- 19.49 of inoculum) compared to nonimmune mice (32.7 +/- 8.7%; P less than 0....

journal_title：Cellular immunology

authors： Morrison CJ,Brummer E,Stevens DA

更新日期：1987-11-01 00:00:00

abstract：:Macrophages are key cell types of innate immunity and play a central role in inflammation and host defense. Leukocyte-associated Ig-like receptor-1 (LAIR-1) is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether LAIR-1 is involved in governing macrophage polarizat...

journal_title：Cellular immunology

authors： Jin J,Wang Y,Ma Q,Wang N,Guo W,Jin B,Fang L,Chen L

更新日期：2018-09-01 00:00:00

abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...

journal_title：Cellular immunology

authors： Zhou M,Chen J,Zhou L,Chen W,Ding G,Cao L

更新日期：2014-11-01 00:00:00

abstract：:Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d...

journal_title：Cellular immunology

authors： Gilmore GL

更新日期：1996-04-10 00:00:00

abstract：:The lpr mutation in mice results in premature termination of transcription of the gene encoding the apoptosis-signaling receptor Fas. As a result, lpr mice develop severe lymphoproliferation and lupus-like autoantibodies. Growing evidence suggests that the lpr mutation is "leaky" and that low levels of Fas are express...

journal_title：Cellular immunology

authors： Weintraub JP,Godfrey V,Wolthusen PA,Cheek RL,Eisenberg RA,Cohen PL

更新日期：1998-05-25 00:00:00

abstract：:Tegumentary leishmaniasis (TL) constitutes a major public health problem with significant morbidity worldwide. Synthetic peptide-based vaccines are attractive candidates to protect against leishmaniasis, since T cell-specific epitopes can be delivery to antigen-presenting cells, leading to the generation of a Th1 cell...

journal_title：Cellular immunology

authors： Martins VT,Lage DP,Duarte MC,Carvalho AM,Costa LE,Mendes TA,Vale DL,Menezes-Souza D,Roatt BM,Tavares CA,Soto M,Coelho EA

更新日期：2017-03-01 00:00:00

abstract：:The purpose of this study is to assess the potential of dendritic cells transfected with PD-L1 recombinant adenovirus induces CD8+ T cell suppression and kidney allograft tolerance. To prove it, DCs transfected with PD-L1 recombinant adenovirus (DC/Ad-PD-L1) were transferred into the MHC-mismatched rat kidney transpla...

journal_title：Cellular immunology

authors： Peng W,Ran B,Ma Y,Huang X,Chang Q,Wang X

更新日期：2011-01-01 00:00:00

abstract：:CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-1...

journal_title：Cellular immunology

authors： Reiser J,Sadashivaiah K,Furusawa A,Banerjee A,Singh N

更新日期：2019-01-01 00:00:00

abstract：:Engraftment of stem cell-enriched donor marrow implanted in the thymus of a foreign host might facilitate acceptance of donor-specific organ or tissue grafts. To test this hypothesis, allogeneic and xenogeneic CD34+ marrow cells from unrelated adult male baboons and humans were injected intrathymically in eight infant...

journal_title：Cellular immunology

authors： Allen MD,Weyhrich J,Gaur L,Akimoto H,Hall J,Dalesandro J,Sai S,Thomas R,Nelson KA,Andrews RG

更新日期：1997-11-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a 17-kDa protein produced by endotoxin-stimulated macrophages. We have demonstrated that recombinant human TNF activates human macrophages to kill intracellular bacteria of the Mycobacterium avium complex (MAC) in a dose-related manner. TNF also primed macrophages to produce superoxide a...

journal_title：Cellular immunology

authors： Bermudez LE,Young LS

更新日期：1992-10-15 00:00:00

abstract：:This report describes a model for investigating the role of the thymus in regulating natural killer (NK) cell activity in vivo. Evidence is presented that the thymus can regulate NK cells, and that at least some NK cells can develop without thymic help. Marrow from thymectomized rats depleted of circulating T cells by...

journal_title：Cellular immunology

authors： Flexman JP,Holt PG,Mayrhofer G,Latham BI,Shellam GR

更新日期：1985-02-01 00:00:00

abstract：:The antifungal activity of nonactivated resident murine peritoneal macrophages for Cryptococcus neoformans was studied. Macrophages from five of six mouse strains tested had significant (40 to 80%) fungistatic activity, depending on the inoculum size, in a 24-hr coculture system. Macrophages from two outbred (SW and I...

journal_title：Cellular immunology

authors： Brummer E,Stevens DA

更新日期：1994-08-01 00:00:00

abstract：:The aim of our work was to study apoptosis as a possible mechanism of CD4+ lymphocyte depletion in AIDS patients and to test whether IL-12 could limit this phenomenon. As an in vitro model, we used a human IL-2-dependent Th1 clone from an uninfected individual. We found that CD4 cross-linking, obtained either by mouse...

journal_title：Cellular immunology

authors： Radrizzani M,Accornero P,Amidei A,Aiello A,Delia D,Kurrle R,Colombo MP

更新日期：1995-03-01 00:00:00

abstract：:Macrophage-mediated cytostasis was measured in a mouse syngeneic system where EL4 thymoma cells were found to be inhibited by C57B1/6 mouse macrophages. When tumor cells were pretreated with TPA, they became resistant to macrophage-mediated stasis. Nonelutriated as well as elutriated cells enriched in G1/early S and l...

journal_title：Cellular immunology

authors： Nycum LM,Fishman M

更新日期：1989-01-01 00:00:00

abstract：:Induction of specific antitumor cytotoxic T cell responses was studied in BALB/c mice bearing tumors transfected with a mutant human p53 minigene. We observed that mice were resistant to the induction of peptide-specific CTL as early as 5 days after challenge with a minimal lethal dose of tumor cells, and the cell typ...

journal_title：Cellular immunology

authors： Gabrilovich DI,Ciernik IF,Carbone DP

更新日期：1996-05-25 00:00:00

abstract：:Mature thymocytes are usually defined and separated from other less mature thymocytes on the basis of their mutually exclusive expression of either CD4 or CD8. However, such murine "single positives" include a subpopulation of immature cells with properties resembling CD4- CD8- thymocytes or CD4+ CD8+ cortical blasts....

journal_title：Cellular immunology

authors： Shortman K,Wilson A,Egerton M,Pearse M,Scollay R

更新日期：1988-05-01 00:00:00