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The CR2 receptor (CD21) shows increased expression in the more differentiated cells of an antigen-specific B cell line.

Abstract：

:The complement receptor 2 (CR2; CD21), a 145,000 MW glycoprotein, has been useful as a marker of B lymphocyte maturation. It is expressed on the 1:13 monoclonal, EBV-transformed, B cell line which produces TNP-specific IgM-kappa and displays an in vitro capacity for differentiation. The line expresses the CD20+CD21+ phenotype. We studied whether CR2 receptor surface expression varied in relation to the cell cycle or state of differentiation in the 1:13 line. High CD21 and IgM expression occurred in the G1 phase of the cell cycle. In contrast to CD21, there were no distinctly brighter subpopulations of CD20 positive cells in the G1, S, or G2M compartments of the cell cycle. When sorted according to size, smaller cells were predominantly in G1, whereas a greater proportion of the larger cells were in the G2M phase of the cell cycle. The smaller 1:13 cells expressed more CD21 surface antigen and IgM than the larger cells. Cells which formed stable rosettes with TNP-SRBC expressed more surface IgM and CD21 antigen than nonrosetting cells. We have previously shown that the TNP-SRBC rosetting cells were more differentiated, resided in G1, and secreted more immunoglobulin than the nonrosetting cells. Thus increased CR2 expression occurred in the more differentiated cells of this human monoclonal B cell line.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Pillemer SR,Tsokos GC,Barbieri SA,Balow JE,Golding B

doi

10.1016/0008-8749(90)90093-7

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

386-95

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(90)90093-7

journal_volume

125

pub_type

杂志文章

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