Prolonged allogeneic and xenogeneic microchimerism in unmatched primates without immunosuppression by intrathymic implantation of CD34+ donor marrow cells.

abstract：:We have systematically studied uncloned human cell lines derived from anti-influenza A virus or anti-Epstein-Barr virus (EBV) bulk cultures, or from cultures highly enriched for CD4+ or CD8+ lymphocytes. The most noteworthy results are the following: (1) Anti-viral bulk cultures consisted of more than 90% of CD8+ cell...

journal_title：Cellular immunology

authors： Gomez A,Bourgault I,Gomard E,Picard F,Levy JP

更新日期：1989-02-01 00:00:00

abstract：:Cyclosporin A (CsA) was tested for its modulatory effects on the mIgM-mediated signaling of G0*-associated increases in class II MHC expression, G1-related RNA synthesis, and S phase-related DNA synthesis in human B cells. While CsA at concentrations as low as 10-100 ng/ml could completely ablate anti-IgM-induced DNA ...

journal_title：Cellular immunology

authors： Mongini PK,Blessinger CA,Dalton JP,Seki T

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:We aim to evaluate the effects of atorvastatin on the expression of Toll-like receptor (TLR4) protein and mRNA, and to explore their effects on TLR4-dependent downstream signaling in human monocytic leukemia (THP-1) cells. METHODS:TLR4 protein and mRNA expression, levels of NF-κB protein, and expression of TNF...

journal_title：Cellular immunology

authors： Yang SS,Li R,Qu X,Fang W,Quan Z

更新日期：2012-09-01 00:00:00

abstract：:Interleukin (IL)-4 has been shown to be secreted simultaneously with IL-2 and interferon (IFN)-gamma by the majority of CD4+ human T cell clones isolated and cultured using IL-2 as a growth factor. Moreover, IL-4 was found to be as efficient as IL-2 to promote the outgrowth of human T cell clones. In this study we hav...

journal_title：Cellular immunology

authors： Paliard X,de Vries JE,Spits H

更新日期：1991-07-01 00:00:00

abstract：:Modification of cytokine production by gender hormones has been postulated to affect disease susceptibility and outcome. Here we investigate the effect of gender and the menstrual cycle on production of cytokines. Mononuclear cells were isolated every week for 10 consecutive weeks from healthy pre-menopausal women and...

journal_title：Cellular immunology

authors： Temple SE,Pham K,Glendenning P,Phillips M,Waterer GW

更新日期：2008-02-01 00:00:00

abstract：:The susceptibility of murine embryonic cells to CTL lysis has been assessed. Zona-free blastocysts were not lysed during 6 hr incubation with CTL sensitized against the embryonic genotype and remained capable of implantation and normal development in vivo as well as outgrowth in vitro. Freshly dissociated cells from p...

journal_title：Cellular immunology

authors： Croy BA,Rossant J

更新日期：1987-02-01 00:00:00

abstract：:Seeking common abnormalities in mice genetically predisposed to lupus-like autoimmune disease, we investigated (1) the ontogeny of Ia antigens (I-A/I-E) on the surfaces of resident peritoneal macrophages (rpM phi) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of M phi-stimulating fac...

journal_title：Cellular immunology

authors： Kofler R,Schreiber RD,Dixon FJ,Theofilopoulos AN

更新日期：1984-08-01 00:00:00

abstract：:Injection of antigen into the thymus of adult animals induces specific systemic tolerance, but the mechanisms of acquired thymic tolerance are not well understood. To investigate these mechanisms we used a model of intrathymic injection of ovalbumin (OVA) in BALB/c mice. We show an antigen-specific decrease in prolife...

journal_title：Cellular immunology

authors： Chen W,Issazadeh S,Sayegh MH,Khoury SJ

更新日期：1997-08-01 00:00:00

abstract：:The clinical outcome of Leishmania pathogenesis ranges from active skin lesions to fatal visceral dissemination and severely impaired T cell immunity. It is well established that a strong Th1 immune response is protective against cutaneous forms of the disease, however a mixed Th1/Th2 response is most commonly observe...

journal_title：Cellular immunology

authors： Banerjee A,Bhattacharya P,Joshi AB,Ismail N,Dey R,Nakhasi HL

更新日期：2016-11-01 00:00:00

abstract：:Antigen-specific T-helper factor (ThF) of CBA (H-2k) origin in the picryl (TNP) contact sensitivity system (Mr 60-70 kDa) was reduced with dithiothreitol under mild conditions. Affinity chromatography on antigen yielded an antigen-binding chain (Mr 20-30 kDa) and an antigen-nonbinding chain (Mr 40-50 kDa). Both chains...

journal_title：Cellular immunology

authors： Little JA,Asherson GL,Colizzi V,Zembala M

更新日期：1988-05-01 00:00:00

abstract：:Macrophage-mediated cytostasis was measured in a mouse syngeneic system where EL4 thymoma cells were found to be inhibited by C57B1/6 mouse macrophages. When tumor cells were pretreated with TPA, they became resistant to macrophage-mediated stasis. Nonelutriated as well as elutriated cells enriched in G1/early S and l...

journal_title：Cellular immunology

authors： Nycum LM,Fishman M

更新日期：1989-01-01 00:00:00

abstract：:Here, we established CD4(+)αβTh1 clones specific for rat vascular smooth muscle antigen (VSMAg) that induced vasculitis lesions in the lungs of MRL/Mp-Fas(+/+) mice following adoptive transfer. Six different T cell clones, MV1b1 (Vβ1), MV1b4 (Vβ4), MV1b8.3 (Vβ8.3), MV1b61 (Vβ6), MV1b62 (Vβ6), and MV1b63 (Vβ6), were is...

journal_title：Cellular immunology

authors： Fujita Y,Fujii T,Shimizu H,Sato T,Nakamura T,Iwao H,Nakajima A,Miki M,Sakai T,Kawanami T,Tanaka M,Masaki Y,Fukushima T,Okazaki T,Umehara H,Mimori T

更新日期：2016-05-01 00:00:00

abstract：:In this study a panel of monoclonal antibodies was used to investigate the kinetics of the appearance of activation-linked surface determinants as well as cytoplasmic and nuclear determinants in human T cells following lectin stimulation. Well known activation markers, such as Ia/DR, transferrin receptor, IL-2 recepto...

journal_title：Cellular immunology

authors： Holter W,Majdic O,Liszka K,Stockinger H,Knapp W

更新日期：1985-02-01 00:00:00

abstract：:The aly, alymphoplasia, is an autosomal recessive mutation in mice of an unknown etiology, which induces total aplasia of lymph nodes and Peyer's patches. We hypothesized that the lack of lymphoid tissue may be due to abnormalities of lymphocyte traffic into these tissues. Therefore, we analyzed the expression of vari...

journal_title：Cellular immunology

authors： Koike R,Watanabe T,Satoh H,Hee CS,Kitada K,Kuramoto T,Serikawa T,Miyawaki S,Miyasaka M

更新日期：1997-08-25 00:00:00

abstract：:We have previously used human Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines for the identification and purification of a novel cytokine, natural killer cell stimulatory factor (NKSF/IL-12), that has pleiotropic effects on human lymphocytes. B cell lines are also routinely employed as feeder cells fo...

journal_title：Cellular immunology

authors： Valiante NM,Rengaraju M,Trinchieri G

更新日期：1992-11-01 00:00:00

abstract：:Mycobacterium bovis BCG and its subcellular components (bacterial extract, culture filtrate, purified protein derivative, and muramyl dipeptide MDP) are potent in vitro IL-6 inducers in spleen cell cultures from uninfected and BCG-infected BALB/c mice. Both plastic adherent and nonadherent spleen cells are capable of ...

journal_title：Cellular immunology

authors： Huygen K,Vandenbussche P,Heremans H

更新日期：1991-10-01 00:00:00

abstract：:Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca(2+)-dependent activation pathway. In the present experiments we studied the pr...

journal_title：Cellular immunology

authors： Somodi S,Balajthy A,Szilágyi O,Pethő Z,Harangi M,Paragh G,Panyi G,Hajdu P

更新日期：2013-01-01 00:00:00

abstract：:PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells, and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform. PD-1Deltaex2 and PD-1Deltaex3 are generated...

journal_title：Cellular immunology

authors： Nielsen C,Ohm-Laursen L,Barington T,Husby S,Lillevang ST

更新日期：2005-06-01 00:00:00

abstract：:Serum of an autoimmune MRL/Mp-lpr/lpr (MRL/l) mouse supported the proliferation of interleukin 3 (IL-3)-dependent cell line, FDC-P2. This IL-3-like activity initially appeared at 1 month of age and increased with age. Females showed higher titers than did males. MRL/Mp-+/+ mouse sera also exhibited such activity, thou...

journal_title：Cellular immunology

authors： Tasaka K,Sakihama T,Shirakura-Shibata Y,Matsuda S,Nakajima Y

更新日期：1989-07-01 00:00:00

abstract：:Neuroendocrine hormones such as growth hormone (GH) and prolactin (PRL) have been demonstrated to accelerate the recovery of the immune response after chemotherapy and bone marrow transplantation and to enhance the restoration of immunity in individuals infected with HIV and in normal individuals with compromised immu...

journal_title：Cellular immunology

authors： Redelman D,Welniak LA,Taub D,Murphy WJ

更新日期：2008-03-01 00:00:00

abstract：:In vitro incubation of the erythroleukemic cell line K562 with interferon-gamma (IFN-gamma) renders these cells relatively resistant to natural killer (NK) cell lysis. However, such treatment does not alter their sensitivity to LAK cell lysis. Thus, the lytic susceptibility of interferon-gamma-treated K562 (I-K562) ce...

journal_title：Cellular immunology

authors： Powell J,Stone J,Chan WC,Yang ZD,Leatherbury A,Sell KW,Wiktor-Jedrzejczak W,Ahmed-Ansari A

更新日期：1989-02-01 00:00:00

abstract：:Mutations in the X-linked inhibitor of apoptosis (XIAP) have recently been identified in patients with the rare genetic disease, X-linked lymphoproliferative syndrome (XLP), which was previously thought to be solely attributable to mutations in a distinct gene, SAP. To further understand the roles of these two factors...

journal_title：Cellular immunology

authors： Rumble JM,Oetjen KA,Stein PL,Schwartzberg PL,Moore BB,Duckett CS

更新日期：2009-01-01 00:00:00

abstract：:Although it is known that IGF-1 increases T lymphocyte proliferation, the regulation of its receptor expression during the process has not been defined. Consequently the regulation of IGF-1R expression by IGF-1 and the activation events in human blood T lymphocytes and the Jurkat T cell line were now investigated. IGF...

journal_title：Cellular immunology

authors： Schillaci R,Brocardo MG,Galeano A,Roldán A

更新日期：1998-02-01 00:00:00

abstract：:Our strategy to use saturation mutagenesis to produce an unbiased collection of major histocompatibility class I mutants has resulted in unpredicted mutant phenotypes. First, we have shown data supporting our earlier work of the Dp20(Y27N) mutant. Allorecognition is altered at the clonal level while no variation in ly...

journal_title：Cellular immunology

authors： Murray R,Katoh K,Alexander J,Muller D,Pederson K,Frelinger JA

更新日期：1990-06-01 00:00:00

abstract：:The kinetics of viability of lymph node and spleen cells of mice genetically selected for "high" or "low" in vitro lymphocyte responsiveness to PHA were studied in PHA or PPD-stimulated short-term cultures. Lo/PHA cells were found to be less viable than Hi/PHA cells in unstimulated control cultures. PHA improved the v...

journal_title：Cellular immunology

authors： Stiffel C,Liacopoulos-Briot M,Decreusefond C,Lambert F

更新日期：1983-04-01 00:00:00

abstract：:Macrophages generated with macrophage-colony stimulating factor (M-CSF) are defective in antigen presenting cell (APC) function, although they do express major histocompatibility (MHC) class II molecules, numerous accessory molecules, and intercellular adhesion molecules. In the present study, we show evidence that th...

journal_title：Cellular immunology

authors： Lee JK,Kim JK,Lee YR,Kim HS,Im SA,Kim K,Lee CK

更新日期：2005-03-01 00:00:00

abstract：:We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory...

journal_title：Cellular immunology

authors： Masucci MG,Stam NJ,Torsteinsdottir S,Neefjes JJ,Klein G,Ploegh HL

更新日期：1989-05-01 00:00:00

abstract：:The effects of oral administration of ovalbumin (OVA) on acute OVA-induced arthritis (OIA) in rats, which is mediated by Arthus reaction to the antigen in the joint space, were investigated. The oral administration of OVA before immunization with OVA significantly suppressed the development of acute OIA in a dose-depe...

journal_title：Cellular immunology

authors： Inada S,Yoshino S,Haque MA,Ogata Y,Kohashi O

更新日期：1997-01-10 00:00:00

abstract：:In the present report, we demonstrated that extrathymic gamma(delta) T cells proliferated in the mixed culture of lymph node cells of BALB/c nu/nu mice and irradiated syngeneic spleen cells (syngeneic MLR). Reverse transcription-polymerase chain reaction (RT-PCR) analyses revealed that V(delta)5 and V(delta)6 were dom...

journal_title：Cellular immunology

authors： Matsuzaki G,Kenai H,Fujise S,Kobayashi N,Kishihara K,Nomoto K

更新日期：1996-10-10 00:00:00

abstract：:American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

journal_title：Cellular immunology

authors： Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

更新日期：2012-10-01 00:00:00