Abstract：
:Supplementation of the diet with fish oil (FO) decreases growth of the Walker 256 tumor and decreases the cachexia associated with tumor-bearing. The mechanisms by which FO inhibits tumor growth and cachexia are unknown. Macrophages are very important in host defence against tumors since they produce several anti-tumor agents which in turn have been shown to be modified by dietary FO, but rarely in the setting of tumor bearing and never in relation to lifelong exposure. In this study, we compared the effects of supplementation of the diet of pregnant and lactating rats and subsequent supplementation of the offspring with coconut fat or FO on macrophage activities involved in anti-tumor defence. FO supplementation was able to induce an increase in phagocytosis, in O2-, H2O2, nitric oxide, and TNF-alpha production by macrophages and in lysosomal volume in non-tumor-bearing rats. However, phagocytosis, production of O2- and H2O2 and lysosomal volume were not affected by the FO diet when rats were bearing tumors, although nitric oxide production was higher in these animals. It appears that tumor bearing activates the innate immune system and that dietary FO has little effect on innate immunity in the presence of Walker 256 tumors. Thus, it is still unclear how FO decreases the growth of Walker 256 tumors and the associated cachexia.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Bonatto SJ,Folador A,Aikawa J,Yamazaki RK,Pizatto N,Oliveira HH,Vecchi R,Curi R,Calder PC,Fernandes LCdoi
10.1016/j.cellimm.2004.12.001subject
Has Abstractpub_date
2004-09-01 00:00:00pages
56-62issue
1-2eissn
0008-8749issn
1090-2163pii
S0008-8749(04)00197-2journal_volume
231pub_type
杂志文章abstract：:Sensitized T lymphocytes can mediate potent antitumor effects when transferred to tumor-bearing animals. Employing the MCA 105 and MCA 106 sarcomas, we were able to generate antitumor effector cells by immunization of syngeneic mice with tumor cells admixed with Corynebacterium parvum. These immune splenocytes could b...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90209-8
更新日期：1989-05-01 00:00:00
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更新日期：1986-02-01 00:00:00
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pub_type： 杂志文章
doi：10.1006/cimm.1994.1230
更新日期：1994-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：1987-04-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2008.11.001
更新日期：2009-01-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2012.05.010
更新日期：2012-05-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90238-m
更新日期：1990-11-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0011
更新日期：1996-01-10 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90403-9
更新日期：1984-07-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(95)80028-h
更新日期：1995-02-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90302-4
更新日期：1988-04-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2008.06.001
更新日期：2008-05-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90235-8
更新日期：1987-07-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90098-a
更新日期：1992-01-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90037-8
更新日期：1988-05-01 00:00:00
abstract：:In vivo treatment with anti-IA antibodies has been shown to induce a haplotype-specific inhibition of EAE when the disease was following passive transfer of MBP-sensitized T cells. In order to determine the mechanism by which anti-IA antibody prevents passively transferred EAE, the homing of radiolabeled cells to the ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90267-f
更新日期：1991-06-01 00:00:00
abstract：:Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses of control mice (Ehr) presented giant tumor cells and many mitotic figures whereas the tumor ti...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.01.002
更新日期：2009-01-01 00:00:00
abstract：:We have investigated the role of interleukin-2 (IL2) as a differentiation factor for human marrow-derived NK cell progenitors and have assessed the effects of interleukin-1 (IL1) on this activity. The effects of these cytokines on early NK cell precursors was determined by testing marrow which had been depleted of mat...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90313-g
更新日期：1990-03-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0061
更新日期：1996-03-15 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.05.002
更新日期：2009-01-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90314-x
更新日期：1986-04-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2007.03.008
更新日期：2007-01-01 00:00:00
abstract：:Earlier work from this laboratory revealed an increase in the level of null (Thy-1-, IgM-) lymphocytes in the maternal lymphoid organs during the first pregnancy in the mouse that was more pronounced during allogeneic pregnancy than during syngeneic pregnancy. In view of the suggestive evidence for the bone marrow ori...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90098-4
更新日期：1984-04-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2016.11.008
更新日期：2017-02-01 00:00:00
abstract：:Induction of specific antitumor cytotoxic T cell responses was studied in BALB/c mice bearing tumors transfected with a mutant human p53 minigene. We observed that mice were resistant to the induction of peptide-specific CTL as early as 5 days after challenge with a minimal lethal dose of tumor cells, and the cell typ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0139
更新日期：1996-05-25 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(83)90214-9
更新日期：1983-10-01 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1998.1394
更新日期：1998-12-15 00:00:00
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journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0020
更新日期：1996-01-10 00:00:00
abstract：:Although it is well established that the processes of cellular proliferation and apoptosis are linked, the role of cell cycle regulators in T cell responses in vivo is not well understood. In recent years, tumor suppressor molecule p19(ARF) has emerged as a key cell cycle regulator important in cellular apoptosis agai...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(02)00597-x
更新日期：2002-10-01 00:00:00
abstract：:Six OKT4+ human T-cell lines that require continuing PHA stimulation and TCGF for continuous growth were established. The cells from all six of these T-cell lines became smaller in size and lost the cell surface Ia antigen when they were grown in phytohemagglutinin (PHA)-depleted growth factor. These cells were unable...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90275-2
更新日期：1984-04-15 00:00:00
