Abstract:
:Macrophages are key cell types of innate immunity and play a central role in inflammation and host defense. Leukocyte-associated Ig-like receptor-1 (LAIR-1) is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether LAIR-1 is involved in governing macrophage polarization is still not clear. Here, we investigated the effect of LAIR-1 on macrophage polarization using human macrophage polarization model with THP-1 cells. It was found that LAIR-1 was highly expressed in THP-1 macrophages. IFN-γ reduced LAIR-1 expression in THP-1 macrophages. However, IL-4 did not have an effect on the expression of LAIR-1. Moreover, activation of LAIR-1 significantly inhibited the proinflammatory M1-like macrophage differentiation and promoted alternative activation of macrophages. Therefore, LAIR-1 may play critical roles in macrophage polarization. This study provides a rationale for macrophage polarization and sheds light on homeostatic mechanism in which LAIR-1 activation can terminate inflammation which may be impaired in patients with autoimmune disease.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Jin J,Wang Y,Ma Q,Wang N,Guo W,Jin B,Fang L,Chen Ldoi
10.1016/j.cellimm.2018.05.011subject
Has Abstractpub_date
2018-09-01 00:00:00pages
78-84eissn
0008-8749issn
1090-2163pii
S0008-8749(18)30250-8journal_volume
331pub_type
杂志文章abstract::The proliferative responses of human peripheral blood mononuclear cells (PBL) and thymocytes to OKT3 monoclonal antibody have been investigated. The PBL response to OKT3 was maximal after 72 hr while that of thymocytes was inappreciable at all times measured. Unlike phytohemagglutinin, OKT3 was unable to elicit the mi...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90105-9
更新日期:1984-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90400-9
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journal_title:Cellular immunology
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更新日期:1984-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1238
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(92)90158-l
更新日期:1992-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90039-t
更新日期:1990-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1293
更新日期:1993-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90238-m
更新日期:1990-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90169-2
更新日期:1984-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/s0008-8749(02)00018-7
更新日期:2002-02-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1105
更新日期:1997-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2020.104173
更新日期:2020-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1024
更新日期:1994-01-01 00:00:00
abstract::T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90117-2
更新日期:1989-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0113
更新日期:1996-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90266-9
更新日期:1989-10-01 00:00:00
abstract::We have previously described a novel human B cell differentiation factor (BCDF), 446-BCDF, that is distinct biochemically and functionally from other cytokines. Since signal transduction pathways involved in human B cell differentiation have been incompletely studied and are poorly understood, we assessed the effects ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1050
更新日期:1995-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2011.06.015
更新日期:2011-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90278-y
更新日期:1990-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90126-6
更新日期:1984-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1177
更新日期:1997-08-25 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2008.07.001
更新日期:2008-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90275-3
更新日期:1986-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90268-6
更新日期:1986-03-01 00:00:00
abstract::In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optima...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90180-7
更新日期:1985-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(86)90014-6
更新日期:1986-06-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2007.05.001
更新日期:2007-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1105
更新日期:1993-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1146
更新日期:1993-06-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90164-9
更新日期:1985-01-01 00:00:00