Abstract:
:CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-10 drive a central memory phenotype in murine CD8+ T cells. Eomes expression led to increased IL-10 expression by the effector CD8+ T cells themselves as well as an increase in the level of the lymph node homing selectin CD62L. Furthermore, exposure of effector CD8+ T cells to IL-10 maintained CD62L expression levels in culture. Thus, Eomes promotes a step-wise transition of effector T cells towards a memory phenotype, synergizing with IL-10 to enhance the expression of CD62L. The early augmentation of lymph node homing markers by Eomes may facilitate the retention of effector T cells in the relatively low inflammatory milieu of the secondary lymphoid organs that promotes central memory development.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Reiser J,Sadashivaiah K,Furusawa A,Banerjee A,Singh Ndoi
10.1016/j.cellimm.2018.11.008subject
Has Abstractpub_date
2019-01-01 00:00:00pages
93-102eissn
0008-8749issn
1090-2163pii
S0008-8749(18)30449-0journal_volume
335pub_type
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